HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy

(2017) Elham Rahimy et al.   JOURNAL OF INFECTIOUS DISEASES

SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV

(2016) Daniel A. Donahue et al.   JOURNAL OF VIROLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Mechanism of soluble beta-amyloid 25–35 neurotoxicity in primary cultured rat cortical neurons

(2016) Yong Wang et al.   NEUROSCIENCE LETTERS

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation

(2015) Kai Xu et al.   GENES & DEVELOPMENT

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

(2015) James R. Edgar et al.   JOURNAL OF CELL SCIENCE

Role of the macrophage in HIV-associated neurocognitive disorders and other comorbidities in patients on effective antiretroviral treatment

(2015) Jay Rappaport et al.   JOURNAL OF NEUROVIROLOGY

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape

(2015) Viviana Simon et al.   NATURE IMMUNOLOGY

HIV-1 assembly, release and maturation

(2015) Eric O. Freed   NATURE REVIEWS MICROBIOLOGY

HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus

(2015) Viacheslav Malikov et al.   Nature Communications

Role of HIV in Amyloid Metabolism

(2014) Mario Ortega et al.   Journal of Neuroimmune Pharmacology

Genetic Analysis Reveals that Amyloid Precursor Protein and Death Receptor 6 Function in the Same Pathway to Control Axonal Pruning Independent of  -Secretase

(2014) O. Olsen et al.   JOURNAL OF NEUROSCIENCE

Controversies in HIV-associated neurocognitive disorders

(2014) Sam Nightingale et al.   LANCET NEUROLOGY

Interactions between ageing and NeuroAIDS

(2014) Joanna Hellmuth et al.   Current Opinion in HIV and AIDS

HIV-1 Induces the Formation of Stable Microtubules to Enhance Early Infection

(2013) Yosef Sabo et al.   Cell Host & Microbe

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

(2013) R. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

Ashwagandha (Withania somnifera) Reverses β-Amyloid1-42 Induced Toxicity in Human Neuronal Cells: Implications in HIV-Associated Neurocognitive Disorders (HAND)

(2013) Kesava Rao Venkata Kurapati et al.   PLoS One

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

(2013) Etienne Morel et al.   Nature Communications

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

HIV-1 Assembly, Budding, and Maturation

(2013) W. I. Sundquist et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

11C-PiB Imaging of Human Immunodeficiency Virus–Associated Neurocognitive Disorder

(2012) Beau M. Ances   ARCHIVES OF NEUROLOGY

Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier

(2012) Ibolya E. András et al.   IUBMB LIFE

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent rodent models for Alzheimer’s disease: clinical implications and basic research

(2011) Nady Braidy et al.   JOURNAL OF NEURAL TRANSMISSION

Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients

(2009) Cristian L. Achim et al.   Journal of Neuroimmune Pharmacology

Acquired immunodeficiency syndrome and the blood-brain barrier

(2009) Nathan S Ivey et al.   JOURNAL OF NEUROVIROLOGY

HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin

(2009) Ibolya E. András et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection

(2009) J. Haedicke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Simvastatin Protects against Amyloid   and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells

(2008) I. E. Andras et al.   MOLECULAR PHARMACOLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE