Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer’s disease?

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

(2019) Lynn Pulliam et al.   JOURNAL OF NEUROVIROLOGY

Dementia: new vistas and opportunities

(2019) Vladimir Hachinski   NEUROLOGICAL SCIENCES

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy

(2018) Leah H. Rubin et al.   AIDS

HIV-1 TAT-mediated microglial activation: Role of mitochondrial dysfunction and defective mitophagy

(2018) Annadurai Thangaraj et al.   Autophagy

Role of the peripheral innate immune system in the development of Alzheimer's disease

(2018) Aurélie Le Page et al.   EXPERIMENTAL GERONTOLOGY

Role of Exosomes in Human Retroviral Mediated Disorders

(2018) Monique Anderson et al.   Journal of Neuroimmune Pharmacology

HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau

(2018) Albert M. Anderson et al.   JOURNAL OF NEUROIMMUNOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?

(2018) Geoffrey Canet et al.   Frontiers in Cellular Neuroscience

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

(2018) Tamas Fulop et al.   Frontiers in Aging Neuroscience

Role of Microbes in the Development of Alzheimer’s Disease: State of the Art – An International Symposium Presented at the 2017 IAGG Congress in San Francisco

(2018) Tamàs Fülöp et al.   Frontiers in Genetics

The antimicrobial protection hypothesis of Alzheimer's disease

(2018) Robert D. Moir et al.   Alzheimers & Dementia

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An Overview of Human Immunodeficiency Virus Type 1-Associated Common Neurological Complications: Does Aging Pose a Challenge?

(2017) Anantha Ram Nookala et al.   JOURNAL OF ALZHEIMERS DISEASE

HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

(2017) Christian Eggers et al.   JOURNAL OF NEUROLOGY

The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration

(2017) Jerel A. Fields et al.   JOURNAL OF NEUROVIROLOGY

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Immunodeficiency Virus Promotes Mitochondrial Toxicity

(2017) Summer J. Rozzi et al.   NEUROTOXICITY RESEARCH

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

HIV Latency: Should We Shock or Lock?

(2017) Gilles Darcis et al.   TRENDS IN IMMUNOLOGY

Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs

(2017) Sébastien Pasquereau et al.   Viruses-Basel

Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications

(2017) Chet Ojha et al.   Viruses-Basel

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

(2017) A Sami Saribas et al.   Cell Death & Disease

HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

(2017) Qingqing Chai et al.   Nature Communications

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

(2017) Gabriele Siegel et al.   Cell Reports

Exploring the Association between Alzheimer’s Disease, Oral Health, Microbial Endocrinology and Nutrition

(2017) Alice Harding et al.   Frontiers in Aging Neuroscience

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Differentiating HIV-Associated Neurocognitive Disorders From Alzheimer’s Disease: an Emerging Issue in Geriatric NeuroHIV

(2017) Benedetta Milanini et al.   Current HIV/AIDS Reports

Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity

(2017) Susann Ludewig et al.   Frontiers in Molecular Neuroscience

Chlamydophila Pneumoniae and the Etiology of Late-Onset Alzheimer's Disease

(2017) Brian J. Balin et al.   JOURNAL OF ALZHEIMERS DISEASE

HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution

(2017) Siew Hwei Yap et al.   PLoS One

Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine

(2017) Liqun Liu et al.   Scientific Reports

HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders

(2017) Yasmin Zeinolabediny et al.   Scientific Reports

Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder

(2016) Thomas M. Gates et al.   AIDS

White matter hyperintensities in relation to cognition in HIV-infected men with sustained suppressed viral load on combination antiretroviral therapy

(2016) Tanja Su et al.   AIDS

Update of Survival for Persons With HIV Infection in Denmark

(2016) Nicolai Lohse et al.   ANNALS OF INTERNAL MEDICINE

Microglial toll-like receptors and Alzheimer’s disease

(2016) Fan Su et al.   BRAIN BEHAVIOR AND IMMUNITY

Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis

(2016) Rick B. Meeker et al.   EXPERIMENTAL NEUROLOGY

Fate of microglia during HIV-1 infection: From activation to senescence?

(2016) Natalie C. Chen et al.   GLIA

Expression Pattern of Scavenger Receptors and Amyloid-β Phagocytosis of Astrocytes and Microglia in Culture are Modified by Acidosis: Implications for Alzheimer’s Disease

(2016) Jaime Eugenín et al.   JOURNAL OF ALZHEIMERS DISEASE

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-Viral Properties of Amyloid-β Peptides

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent developments in the effort to cure HIV infection: going beyond N = 1

(2016) Janet D. Siliciano et al.   JOURNAL OF CLINICAL INVESTIGATION

Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation

(2016) Mahmoud L. Soliman et al.   Journal of Neuroimmune Pharmacology

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

(2016) Barry W. Festoff et al.   Journal of Neuroinflammation

Alzheimer disease: modeling an Aβ-centered biological network

(2016) D Campion et al.   MOLECULAR PSYCHIATRY

Immunomodulatory effects of exosomes produced by virus-infected cells

(2016) Juraj Petrik   TRANSFUSION AND APHERESIS SCIENCE

An Overview of Genome-Wide Association Studies in Alzheimer’s Disease

(2016) Luxi Shen et al.   Neuroscience Bulletin

Targeting the Brain Reservoirs: Toward an HIV Cure

(2016) Céline Marban et al.   Frontiers in Immunology

TNF and HIV-1 Nef: An Intimate Interplay

(2016) Georges Herbein   EBioMedicine

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

(2016) Christian Ostalecki et al.   EBioMedicine

Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

(2016) Magnus Gisslén et al.   EBioMedicine

Limited HIV-1 Reactivation in Resting CD4+ T cells from Aviremic Patients under Protease Inhibitors

(2016) Amit Kumar et al.   Scientific Reports

Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications

(2015) Suzi Hong et al.   BRAIN BEHAVIOR AND IMMUNITY

HIV-1 Tat-Induced Changes in Synaptically-Driven Network Activity Adapt During Prolonged Exposure

(2015) Kelly Krogh et al.   CURRENT HIV RESEARCH

Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders

(2015) Jerel Fields et al.   CURRENT HIV RESEARCH

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

The aliens inside human DNA: HERV-W/MSRV/syncytin-1 endogenous retroviruses and neurodegeneration

(2015) Antonina Dolei et al.   Journal of Infection in Developing Countries

Autophagy restricts HIV-1 infection

(2015) Coralie F. Daussy et al.   Oncotarget

Differential signaling mechanism for HIV-1 Nef-mediated production of IL-6 and IL-8 in human astrocytes

(2015) Xun Liu et al.   Scientific Reports

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

(2015) Grant R. Campbell et al.   PLoS Pathogens

Neuropathology of HAND With Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered

(2015) Benjamin B. Gelman   Current HIV/AIDS Reports

HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-κB Pathway

(2015) Nawal Ben Haij et al.   PLoS One

HIV Tat acts on endogenous retroviruses of the W family and this occurs via Toll-like receptor 4

(2014) Elena Uleri et al.   AIDS

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

Amyloid and Alzheimer's Disease: Inside and Out

(2014) Joshua H. K. Tam et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

HIV-1 Tat protein induces glial cell autophagy through enhancement of BAG3 protein levels

(2014) Anna Paola Bruno et al.   CELL CYCLE

Role of HIV in Amyloid Metabolism

(2014) Mario Ortega et al.   Journal of Neuroimmune Pharmacology

Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes

(2014) Anantha Ram Nookala et al.   Journal of Neuroinflammation

Activation of TRPML1 Clears Intraneuronal A  in Preclinical Models of HIV Infection

(2014) M. Bae et al.   JOURNAL OF NEUROSCIENCE

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

(2014) Chulman Jo et al.   Nature Communications

HIV and aging

(2014) Peter W. Hunt   Current Opinion in HIV and AIDS

Encephalitis with Infiltration by CD8+ Lymphocytes in HIV Patients Receiving Combination Antiretroviral Treatment

(2013) Françoise Gray et al.   BRAIN PATHOLOGY

HIV-1 Tat C Modulates Expression of miRNA-101 to Suppress VE-Cadherin in Human Brain Microvascular Endothelial Cells

(2013) R. Mishra et al.   JOURNAL OF NEUROSCIENCE

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

(2013) Wen-Yuan Wang et al.   NATURE NEUROSCIENCE

Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production

(2013) Xuesong Chen et al.   NEUROBIOLOGY OF AGING

HIV-1 Tat Interacts with and Regulates the Localization and Processing of Amyloid Precursor Protein

(2013) Jiyoung Kim et al.   PLoS One

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

(2013) Etienne Morel et al.   Nature Communications

HIV: Cell Binding and Entry

(2013) C. B. Wilen et al.   Cold Spring Harbor Perspectives in Medicine

Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers

(2012) Virawudh Soontornniyomkij et al.   AIDS

11C-PiB Imaging of Human Immunodeficiency Virus–Associated Neurocognitive Disorder

(2012) Beau M. Ances   ARCHIVES OF NEUROLOGY

Role of Endolysosomes in HIV-1 Tat-Induced Neurotoxicity

(2012) Liang Hui et al.   ASN Neuro

Autophagy in astrocytes

(2012) Chiara Di Malta et al.   Autophagy

Cognitive impairment in HIV infection is associated with MRI and CSF pattern of neurodegeneration

(2012) F. Steinbrink et al.   EUROPEAN JOURNAL OF NEUROLOGY

Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

(2012) Denise Galante et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?

(2012) Santhi Gorantla et al.   Journal of Neuroimmune Pharmacology

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rodent models for HIV-associated neurocognitive disorders

(2012) Santhi Gorantla et al.   TRENDS IN NEUROSCIENCES

CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy

(2011) Ronald J. Ellis et al.   AIDS

HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9

(2011) Ruifen Xu et al.   BRAIN RESEARCH

Recent rodent models for Alzheimer’s disease: clinical implications and basic research

(2011) Nady Braidy et al.   JOURNAL OF NEURAL TRANSMISSION

HIV-1 gp120-Induced Axonal Injury Detected by Accumulation of β-Amyloid Precursor Protein in Adult Rat Corpus Callosum

(2011) Jingdong Zhang et al.   Journal of Neuroimmune Pharmacology

Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders

(2011) Brian Giunta et al.   Molecular Brain

HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction

(2010) James CB Li et al.   AIDS

Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome

(2010) L. R. V. Antonelli et al.   BLOOD

Does highly active antiretroviral therapy improve neurocognitive function? A systematic review

(2010) John A Joska et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures

(2010) M.Y. Aksenov et al.   NEUROSCIENCE LETTERS

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Mitochondria Influence Fas Expression in GP120-Induced Apoptosis of Neuronal Cells

(2009) Sunil Thomas et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients

(2009) Cristian L. Achim et al.   Journal of Neuroimmune Pharmacology

CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease

(2009) D. B. Clifford et al.   NEUROLOGY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Role of HERV-W Syncytin-1 in Placentation and Maintenance of Human Pregnancy

(2009) Samina Noorali et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Is HIV infection a TNF receptor signalling-driven disease?

(2008) Georges Herbein et al.   TRENDS IN IMMUNOLOGY