The Great Escape: how phosphatidylinositol 4-kinases and PI4P promote vesicle exit from the Golgi (and drive cancer)
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Great Escape: how phosphatidylinositol 4-kinases and PI4P promote vesicle exit from the Golgi (and drive cancer)
Authors
Keywords
-
Journal
BIOCHEMICAL JOURNAL
Volume 476, Issue 16, Pages 2321-2346
Publisher
Portland Press Ltd.
Online
2019-08-28
DOI
10.1042/bcj20180622
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Silencing of type II Phosphatidylinositol 4-kinase β stabilizes Prostate apoptosis response-4 and induces apoptosis in cancer cells
- (2019) Sonica Chaudhry et al. BIOCHEMICAL JOURNAL
- A complex between phosphatidylinositol 4 kinase IIα and integrin α3β1 is required for N-glycan sialylation in cancer cells
- (2019) Tomoya Isaji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The activity of Sac1 across ER–TGN contact sites requires the four-phosphate-adaptor-protein-1
- (2019) Rossella Venditti et al. JOURNAL OF CELL BIOLOGY
- A large scale high throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha
- (2019) Nivedita Sengupta et al. JOURNAL OF LIPID RESEARCH
- Emerging Roles of Neuronal Ca2+ Sensor-1 in Cardiac and Neuronal Tissues: A Mini Review
- (2019) Tomoe Y. Nakamura et al. Frontiers in Molecular Neuroscience
- Phosphatidylinositol 4-kinase IIIβ (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins
- (2019) Dominika Chalupska et al. Scientific Reports
- The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner
- (2019) Cecilia Arriagada et al. PLoS One
- A nuclear phosphoinositide kinase complex regulates p53
- (2019) Suyong Choi et al. NATURE CELL BIOLOGY
- IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis
- (2019) Sabrya C. Carim et al. CURRENT BIOLOGY
- Efficient Golgi Forward Trafficking Requires GOLPH3-Driven, PI4P-Dependent Membrane Curvature
- (2019) Juliati Rahajeng et al. DEVELOPMENTAL CELL
- UCT943, a next generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria
- (2018) Christel Brunschwig et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Comobility of GABARAP and Phosphatidylinositol 4-Kinase 2A on Cytoplasmic Vesicles
- (2018) Yan Chen et al. BIOCHEMISTRY
- Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma progression by activating mTOR signaling pathway
- (2018) Hongying Liu et al. BMC CANCER
- Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1
- (2018) Wenjie Dong et al. Cancer Cell International
- A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis
- (2018) Zhigang Xie et al. DEVELOPMENTAL CELL
- Overexpressed ACBD3 has prognostic value in human breast cancer and promotes the self-renewal potential of breast cancer cells by activating the Wnt/beta-catenin signaling pathway
- (2018) Yun Huang et al. EXPERIMENTAL CELL RESEARCH
- The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response
- (2018) Yuanyuan Su et al. JOURNAL OF CELL SCIENCE
- Formation of COPI-coated vesicles at a glance
- (2018) Eric C. Arakel et al. JOURNAL OF CELL SCIENCE
- STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer
- (2018) Fan Wu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria
- (2018) Nishanth Kandepedu et al. JOURNAL OF MEDICINAL CHEMISTRY
- GOLPH3 promotes glioma progression via facilitating JAK2–STAT3 pathway activation
- (2018) Shishuang Wu et al. JOURNAL OF NEURO-ONCOLOGY
- CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis
- (2018) Ying-nan Wang et al. ONCOGENE
- Investigating sulfoxide to sulfone conversion as a prodrug strategy for a PI4K inhibitor in a humanized mouse model of malaria
- (2018) Liezl Gibhard et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- GOLPH3: A Golgi phosphatidylinositol(4)phosphate effector that directs vesicle trafficking and drives cancer
- (2018) Ramya S. Kuna et al. JOURNAL OF LIPID RESEARCH
- Type II phosphatidylinositol 4-kinase regulates nerve terminal growth and synaptic vesicle recycling
- (2018) Kristyn C. Cantarutti et al. JOURNAL OF NEUROGENETICS
- The Role of Alcohol-induced Golgi Fragmentation for Androgen Receptor Signaling in Prostate Cancer
- (2018) Sonia Manca et al. MOLECULAR CANCER RESEARCH
- The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor
- (2018) Martuza Sarwar et al. ONCOGENE
- Recycling of Golgi glycosyltransferases requires direct binding to coatomer
- (2018) Lin Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production
- (2018) Rafael Gil de Rubio et al. Science Signaling
- Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
- (2018) Hema Adhikari et al. Nature Communications
- Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death
- (2018) Haley Hieronymus et al. eLife
- RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus
- (2018) Koji Nakajima et al. Autophagy
- Accumulation of PtdIns(4)P at the Golgi mediated by reversible oxidation of the PtdIns(4)P phosphatase Sac1 by H2O2
- (2018) Jung Mi Lim et al. FREE RADICAL BIOLOGY AND MEDICINE
- The diverse consequences of aneuploidy
- (2018) Narendra Kumar Chunduri et al. NATURE CELL BIOLOGY
- Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma
- (2018) Nilah M. Ioannidis et al. Nature Communications
- Inactivation of the PtdIns(4)P phosphatase Sac1 at the Golgi by H2O2 produced via Ca2+-dependent Duox in EGF-stimulated cells
- (2018) Sujin Park et al. FREE RADICAL BIOLOGY AND MEDICINE
- Regulation of actin dynamics by PI(4,5)P2 in cell migration and endocytosis
- (2018) Yosuke Senju et al. CURRENT OPINION IN CELL BIOLOGY
- COG7 deficiency inDrosophilagenerates multifaceted developmental, behavioral and protein glycosylation phenotypes
- (2017) Anna Frappaolo et al. JOURNAL OF CELL SCIENCE
- The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway
- (2017) Shanyang He et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Structural analysis of phosphatidylinositol 4-kinase IIIβ (PI4KB) – 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro
- (2017) Dominika Chalupska et al. JOURNAL OF STRUCTURAL BIOLOGY
- Calcium Sensor, NCS-1, Promotes Tumor Aggressiveness and Predicts Patient Survival
- (2017) Lauren M. Moore et al. MOLECULAR CANCER RESEARCH
- GOLPH3 expression promotes the resistance of HT29 cells to 5‑fluorouracil by activating multiple signaling pathways
- (2017) Ming‑Zhen Wang et al. Molecular Medicine Reports
- Hypoxia-induced Rab11-family interacting protein�4�expression promotes migration and invasion of colon cancer and correlates with poor prognosis
- (2017) Jian‑Zhang Wang et al. Molecular Medicine Reports
- GOLPH3 promotes cell proliferation and tumorigenicity in esophageal squamous cell carcinoma via mTOR and Wnt/β-catenin signal activation
- (2017) Jian-Hua Wang et al. Molecular Medicine Reports
- A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
- (2017) Ujjini H. Manjunatha et al. NATURE
- Golgi phosphoprotein 3 promotes glioma progression via inhibiting Rab5-mediated endocytosis and degradation of epidermal growth factor receptor
- (2017) Xiuping Zhou et al. NEURO-ONCOLOGY
- MicroRNA-134 suppresses cell proliferation in gastric cancer cells via targeting of GOLPH3
- (2017) Yanqi Liu et al. ONCOLOGY REPORTS
- Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to thetrans-Golgi network
- (2017) Lydia Daboussi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
- (2017) Tanya Paquet et al. Science Translational Medicine
- The role of oxysterol-binding protein and its related proteins in cancer
- (2017) Ximing Du et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- GOLPH3 and oncogenesis: What is the molecular link?
- (2017) Riccardo Rizzo et al. TISSUE & CELL
- Spatiotemporal Control of Lipid Conversion, Actin-Based Mechanical Forces, and Curvature Sensors during Clathrin/AP-1-Coated Vesicle Biogenesis
- (2017) Mihaela Anitei et al. Cell Reports
- The Role of GOLPH3L in the Prognosis and NACT response in Cervical Cancer
- (2017) Yanling Feng et al. Journal of Cancer
- CENPH Inhibits Rapamycin Sensitivity by Regulating GOLPH3-dependent mTOR Signaling Pathway in Colorectal Cancer
- (2017) Wei Wu et al. Journal of Cancer
- Allosteric Regulation of Phosphatidylinositol 4-Kinase III Beta by an Antipicornavirus Compound MDL-860
- (2017) Minetaro Arita et al. ACS Infectious Diseases
- Control of diverse subcellular processes by a single multi-functional lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]
- (2016) S. Kolay et al. BIOCHEMICAL JOURNAL
- The counterflow transport of sterols and PI4P
- (2016) Bruno Mesmin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Chromosomal instability: A common feature and a therapeutic target of cancer
- (2016) Kozo Tanaka et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion
- (2016) Nils Halberg et al. CANCER CELL
- Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer
- (2016) Takeshi Ijuin et al. CANCER SCIENCE
- Golgi membrane‐associated degradation pathway in yeast and mammals
- (2016) Hirofumi Yamaguchi et al. EMBO JOURNAL
- Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells
- (2016) Mafalda Lopes da Silva et al. JOURNAL OF CELL SCIENCE
- Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11
- (2016) Xiaochao Tan et al. JOURNAL OF CLINICAL INVESTIGATION
- Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ
- (2016) Florentine U. Rutaganira et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology
- (2016) Ivana Mejdrová et al. JOURNAL OF MEDICINAL CHEMISTRY
- OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates
- (2016) Peter G. Billcliff et al. MOLECULAR BIOLOGY OF THE CELL
- PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes
- (2016) Yuji Henmi et al. MOLECULAR BIOLOGY OF THE CELL
- GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge
- (2016) Mengke Xing et al. MOLECULAR BIOLOGY OF THE CELL
- Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype
- (2016) Ganiyu Olabanji Alli-Balogun et al. MOLECULAR BIOLOGY OF THE CELL
- A phosphoinositide conversion mechanism for exit from endosomes
- (2016) Katharina Ketel et al. NATURE
- Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants
- (2016) Ruibin Xi et al. NUCLEIC ACIDS RESEARCH
- Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ
- (2016) Alessandro Pagliuso et al. Nature Communications
- PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis
- (2016) Giulia Mana et al. Nature Communications
- Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes enzalutamide resistance in prostate cancer cells
- (2016) Martuza Sarwar et al. Oncotarget
- GOLPH3 overexpression correlates with poor response to neoadjuvant therapy and prognosis in locally advanced rectal cancer
- (2016) Kunli Zhu et al. Oncotarget
- Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells
- (2016) Cheng-Zhi Qiu et al. Journal of Cancer
- Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231
- (2016) María J. Tenorio et al. PLoS One
- Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein
- (2016) Martin Klima et al. Scientific Reports
- GABARAP-mediated targeting of PI4K2A/PI4KIIα to autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion
- (2015) Joseph Albanesi et al. Autophagy
- A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells
- (2015) Patrick Weber et al. BMC Systems Biology
- Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer
- (2015) Grace O. Silva et al. BREAST CANCER RESEARCH AND TREATMENT
- GOLPH3 Links the Golgi, DNA Damage, and Cancer
- (2015) M. D. Buschman et al. CANCER RESEARCH
- GOLPH3 Overexpression is Closely Correlated with Poor Prognosis in Human Non-Small Cell Lung Cancer and Mediates its Metastasis Through Upregulating MMP-2 and MMP-9
- (2015) Ran Wang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Phosphatidylinositol 4-kinases: Function, structure, and inhibition
- (2015) Evzen Boura et al. EXPERIMENTAL CELL RESEARCH
- Mitotic Golgi translocation of ERK1c is mediated by a PI4KIII -14-3-3 shuttling complex
- (2015) I. Wortzel et al. JOURNAL OF CELL SCIENCE
- Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action
- (2015) Ivana Mejdrová et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A
- (2015) Minetaro Arita et al. MICROBIOLOGY AND IMMUNOLOGY
- Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells
- (2015) Dayani Rajamanoharan et al. MOLECULAR BIOLOGY OF THE CELL
- High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma
- (2015) QIAN LI et al. Molecular Medicine Reports
- GOLPH3 Mediated Golgi Stress Response in Modulating N2A Cell Death upon Oxygen-Glucose Deprivation and Reoxygenation Injury
- (2015) Ting Li et al. MOLECULAR NEUROBIOLOGY
- Structure of Rab11–FIP3–Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11
- (2015) Melanie Vetter et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum
- (2015) Kanika Bajaj Pahuja et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of Rab11–FIP3–Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11
- (2015) Melanie Vetter et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy
- (2015) Qing Zhang et al. Oncotarget
- A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation
- (2015) Carmen Ruggiero et al. Oncotarget
- Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer
- (2015) Wenzhi Li et al. Journal of Cancer
- The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design
- (2015) Martin Klima et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Modeling the effects of cyclodextrin on intracellular membrane vesicles from Cos-7 cells prepared by sonication and carbonate treatment
- (2015) Peter Kilbride et al. PeerJ
- Lentivirus Mediated GOLPH3 shRNA Inhibits Growth and Metastasis of Esophageal Squamous Cancer
- (2014) Qiang Wang et al. Asian Pacific Journal of Cancer Prevention
- GOLPH3, a Good Prognostic Indicator in Early-stage NSCLC Related to Tumor Angiogenesis
- (2014) Ming Lu et al. Asian Pacific Journal of Cancer Prevention
- PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes
- (2014) James W. Robinson et al. BIOCHEMICAL JOURNAL
- Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3
- (2014) Xiuping Zhou et al. CANCER LETTERS
- Tetraspanin-enriched microdomains and hepatocellular carcinoma progression
- (2014) Antonio Mazzocca et al. CANCER LETTERS
- Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell-Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
- (2014) E. Tokuda et al. CANCER RESEARCH
- DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3
- (2014) Suzette E. Farber-Katz et al. CELL
- The crystal structure of the phosphatidylinositol 4-kinase II
- (2014) A. Baumlova et al. EMBO REPORTS
- An Oncogenic Protein Golgi Phosphoprotein 3 Up-regulates Cell Migration via Sialylation
- (2014) Tomoya Isaji et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Golgi Phosphoprotein 3 Triggers Signal-mediated Incorporation of Glycosyltransferases into Coatomer-coated (COPI) Vesicles
- (2014) Elias S. P. Eckert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Golgi Phosphoprotein 3 Mediates the Golgi Localization and Function of ProteinO-Linked Mannose β-1,2-N-Acetlyglucosaminyltransferase 1
- (2014) Natasha A. Pereira et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sac1–Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus
- (2014) Yiying Cai et al. JOURNAL OF CELL BIOLOGY
- A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
- (2014) Gerald R.V. Hammond et al. JOURNAL OF CELL BIOLOGY
- Endosomal sorting of VAMP3 is regulated by PI4K2A
- (2014) M. Jovi et al. JOURNAL OF CELL SCIENCE
- GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy
- (2014) Zaozao Wang et al. Journal of Translational Medicine
- The Lipid Kinase PI4KIIIβ Is Highly Expressed in Breast Tumors and Activates Akt in Cooperation with Rab11a
- (2014) Anne A. Morrow et al. MOLECULAR CANCER RESEARCH
- Restoration of Compact Golgi Morphology in Advanced Prostate Cancer Enhances Susceptibility to Galectin-1-Induced Apoptosis by Modifying Mucin O-Glycan Synthesis
- (2014) A. Petrosyan et al. MOLECULAR CANCER RESEARCH
- GOLPH3 promotes glioblastoma cell migration and invasion via the mTOR-YB1 pathway in vitro
- (2014) Xu Zhang et al. MOLECULAR CARCINOGENESIS
- Mechanisms of GOLPH3 Associated with the Progression of Gastric Cancer: A Preliminary Study
- (2014) Jinzhen Peng et al. PLoS One
- The role of PI3K/AKT-related PIP5K1 and the discovery of its selective inhibitor for treatment of advanced prostate cancer
- (2014) J. Semenas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PIP5K1 inhibition as a therapeutic strategy for prostate cancer
- (2014) J. M. Drake et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current
- (2014) E. J. Dickson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors
- (2014) J. E. Burke et al. SCIENCE
- Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα
- (2014) Qiangjun Zhou et al. Nature Communications
- Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy
- (2014) Jiangmei Li et al. Protein & Cell
- Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer
- (2014) Mark G. Waugh Journal of Cancer
- Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal PhenotypeIn Vivo
- (2013) Catherine Spickler et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- GOLPH3 regulates the migration and invasion of glioma cells though RhoA
- (2013) Xiuping Zhou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP
- (2013) Bruno Mesmin et al. CELL
- Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy
- (2013) Lianghui Zhang et al. CELL
- PI4K2β/AP-1-Based TGN-Endosomal Sorting Regulates Wnt Signaling
- (2013) Marnix Wieffer et al. CURRENT BIOLOGY
- Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export
- (2013) David Cruz-Garcia et al. EMBO JOURNAL
- Functional Characterization of Human Myosin-18A and Its Interaction with F-actin and GOLPH3
- (2013) Manuel H. Taft et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Off–On COX-2-Specific Fluorescent Probe: Targeting the Golgi Apparatus of Cancer Cells
- (2013) Hua Zhang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- GOLPH3L antagonizes GOLPH3 to determine Golgi morphology
- (2013) Michelle M. Ng et al. MOLECULAR BIOLOGY OF THE CELL
- The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky–Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα
- (2013) P. V. Ryder et al. MOLECULAR BIOLOGY OF THE CELL
- Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi
- (2013) Giovanni D’Angelo et al. NATURE
- Targeting Plasmodium PI(4)K to eliminate malaria
- (2013) Case W. McNamara et al. NATURE
- Raft-like membranes from the trans-Golgi network and endosomal compartments
- (2013) Mark G Waugh Nature Protocols
- 14-3-3 protein and ATRAP bind to the soluble class IIB phosphatidylinositol transfer protein RdgBβ at distinct sites
- (2012) Shamshad Cockcroft et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion
- (2012) Eija Nissilä et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer
- (2012) Mark G. Waugh CANCER LETTERS
- Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells
- (2012) Ahmed F. Salem et al. CELL CYCLE
- Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells
- (2012) Federica Sotgia et al. CELL CYCLE
- Overexpression of GOLPH3 Promotes Proliferation and Tumorigenicity in Breast Cancer via Suppression of the FOXO1 Transcription Factor
- (2012) Z. Zeng et al. CLINICAL CANCER RESEARCH
- Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila
- (2012) J. Burgess et al. DEVELOPMENT
- A new class of carriers that transport selective cargo from the trans Golgi network to the cell surface
- (2012) Yuichi Wakana et al. EMBO JOURNAL
- Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch
- (2012) Julia Mössinger et al. EMBO REPORTS
- Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
- (2012) Jack-Christophe Cossec et al. HUMAN MOLECULAR GENETICS
- Phosphatidylinositol Transfer Protein, Cytoplasmic 1 (PITPNC1) Binds and Transfers Phosphatidic Acid
- (2012) Kathryn Garner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphatidylinositol 4-Kinase IIα Is Palmitoylated by Golgi-localized Palmitoyltransferases in Cholesterol-dependent Manner
- (2012) Dongmei Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Overexpression of Golgi phosphoprotein-3 (GOLPH3) in glioblastoma multiforme is associated with worse prognosis
- (2012) Jinxu Zhou et al. JOURNAL OF NEURO-ONCOLOGY
- Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes
- (2012) Nagendran Muthusamy et al. JOURNAL OF NEUROCHEMISTRY
- Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase
- (2012) Christopher S. Wood et al. MOLECULAR BIOLOGY OF THE CELL
- Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase
- (2012) Marko Jović et al. MOLECULAR BIOLOGY OF THE CELL
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
- (2012) Christina Curtis et al. NATURE
- Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network
- (2012) Lydia Daboussi et al. NATURE CELL BIOLOGY
- A 14-3-3γ dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation
- (2012) Carmen Valente et al. NATURE CELL BIOLOGY
- Lipid membrane curvature induced by distearoyl phosphatidylinositol 4-phosphate
- (2012) Samuel Furse et al. Soft Matter
- The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein)
- (2011) Kathryn Garner et al. BIOCHEMICAL JOURNAL
- Molecular structure and target recognition of neuronal calcium sensor proteins
- (2011) James B. Ames et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Alteration of Golgi structure in senescent cells and its regulation by a G protein γ subunit
- (2011) Joon-Ho Cho et al. CELLULAR SIGNALLING
- The Inositol 5-Phosphatase dOCRL Controls PI(4,5)P2 Homeostasis and Is Necessary for Cytokinesis
- (2011) Khaled Ben El Kadhi et al. CURRENT BIOLOGY
- Structure of a Ca2+-Myristoyl Switch Protein That Controls Activation of a Phosphatidylinositol 4-Kinase in Fission Yeast
- (2011) Sunghyuk Lim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protection of Neuronal Calcium Sensor 1 Protein in Cells Treated with Paclitaxel
- (2011) Jennifer H. Benbow et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A calmodulin-related light chain from fission yeast that functions with myosin-I and PI 4-kinase
- (2011) M. R. Sammons et al. JOURNAL OF CELL SCIENCE
- The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway
- (2011) Christopher J. Noakes et al. MOLECULAR BIOLOGY OF THE CELL
- The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse
- (2011) Jennifer Larimore et al. MOLECULAR BIOLOGY OF THE CELL
- Natural products reveal cancer cell dependence on oxysterol-binding proteins
- (2011) Anthony W G Burgett et al. Nature Chemical Biology
- Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma
- (2011) Takao Setoguchi ONCOLOGY REPORTS
- Filopodia and adhesion in cancer cell motility
- (2011) Antti Arjonen et al. Cell Adhesion & Migration
- Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains
- (2010) Marc Lenoir et al. EMBO REPORTS
- Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITP is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum
- (2010) N. Carvou et al. JOURNAL OF CELL SCIENCE
- The phosphatidylinositol 4-kinase PI4KIII is required for the recruitment of GBF1 to Golgi membranes
- (2010) K. Dumaresq-Doiron et al. JOURNAL OF CELL SCIENCE
- Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIα at thetrans-Golgi network
- (2010) Shane Minogue et al. JOURNAL OF LIPID RESEARCH
- Detergent-free isolation and characterization of cholesterol-rich membrane domains fromtrans-Golgi network vesicles
- (2010) Mark G. Waugh et al. JOURNAL OF LIPID RESEARCH
- Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity
- (2010) M. Arita et al. JOURNAL OF VIROLOGY
- Oxysterol Binding Protein-dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires Phosphatidylinositol 4-Kinase IIα
- (2010) Sangeeta Banerji et al. MOLECULAR BIOLOGY OF THE CELL
- PI4KIIα is a novel regulator of tumor growth by its action on angiogenesis and HIF-1α regulation
- (2010) J Li et al. ONCOGENE
- Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling
- (2010) Z. Szentpetery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spatial Regulation of Golgi Phosphatidylinositol-4-Phosphate is Required for Enzyme Localization and Glycosylation Fidelity
- (2010) Fei Ying Cheong et al. TRAFFIC
- Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis
- (2010) K M E Chu et al. Cell Death & Disease
- GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding
- (2009) Holly C. Dippold et al. CELL
- Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by μ-calpain disrupts calcium binding
- (2009) Courtney Blachford et al. CELL CALCIUM
- A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum
- (2009) Werner Leber et al. INTERNATIONAL JOURNAL FOR PARASITOLOGY
- Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIα
- (2009) Barbara Barylko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl
- (2009) Yuanbo Qin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual roles for theDrosophilaPI 4-kinase Four wheel drive in localizing Rab11 during cytokinesis
- (2009) Gordon Polevoy et al. JOURNAL OF CELL BIOLOGY
- PtdIns4Precognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking
- (2009) Christopher S. Wood et al. JOURNAL OF CELL BIOLOGY
- Frequenin/NCS-1 and the Ca2+-channel 1-subunit co-regulate synaptic transmission and nerve-terminal growth
- (2009) J. S. Dason et al. JOURNAL OF CELL SCIENCE
- Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication
- (2009) J. Borawski et al. JOURNAL OF VIROLOGY
- Oxysterol Binding Protein–related Protein 9 (ORP9) Is a Cholesterol Transfer Protein That Regulates Golgi Structure and Function
- (2009) Mike Ngo et al. MOLECULAR BIOLOGY OF THE CELL
- Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
- (2009) Zachary T. Schafer et al. NATURE
- GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
- (2009) Kenneth L. Scott et al. NATURE
- OCRL1 Mutations in Dent 2 Patients Suggest a Mechanism for Phenotypic Variability
- (2009) Antony E. Shrimpton et al. NEPHRON PHYSIOLOGY
- GOLPH3 links the Golgi network to mTOR signaling and human cancer
- (2009) Robert T. Abraham Pigment Cell & Melanoma Research
- Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking
- (2009) M. Mikhaylova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Golgi protein FAPP2 tubulates membranes
- (2009) Xinwang Cao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Golgi Localization of Glycosyltransferases Requires a Vps74p Oligomer
- (2008) Karl R. Schmitz et al. DEVELOPMENTAL CELL
- Tetraspanin CD81-Regulated Cell Motility Plays a Critical Role in Intrahepatic Metastasis of Hepatocellular Carcinoma
- (2008) Antonio Mazzocca et al. GASTROENTEROLOGY
- Hermansky-Pudlak Syndrome Protein Complexes Associate with Phosphatidylinositol 4-Kinase Type II α in Neuronal and Non-neuronal Cells
- (2008) Gloria Salazar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1
- (2008) Anastasia Blagoveshchenskaya et al. JOURNAL OF CELL BIOLOGY
- Eukaryotic Elongation Factor 1A2 Cooperates with Phosphatidylinositol-4 Kinase III To Stimulate Production of Filopodia through Increased Phosphatidylinositol-4,5 Bisphosphate Generation
- (2008) S. Jeganathan et al. MOLECULAR AND CELLULAR BIOLOGY
- The Sac1 Phosphoinositide Phosphatase Regulates Golgi Membrane Morphology and Mitotic Spindle Organization in Mammals
- (2008) Yang Liu et al. MOLECULAR BIOLOGY OF THE CELL
- The Clathrin Adaptor Gga2p Is a Phosphatidylinositol 4-phosphate Effector at the Golgi Exit
- (2008) Lars Demmel et al. MOLECULAR BIOLOGY OF THE CELL
- Phosphatidylinositol-4-Kinase Type II Alpha Contains an AP-3–sorting Motif and a Kinase Domain That Are Both Required for Endosome Traffic
- (2008) Branch Craige et al. MOLECULAR BIOLOGY OF THE CELL
- Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
- (2008) S. V. Voronov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation
- (2008) W. Pan et al. SCIENCE
- Signal-Mediated Dynamic Retention of Glycosyltransferases in the Golgi
- (2008) L. Tu et al. SCIENCE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started