STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Design, Synthesis, and Biological Evaluation of 68Ga-DOTA–PA1 for Lung Cancer: A Novel PET Tracer for Multiple Somatostatin Receptor Imaging

(2018) Fei Liu et al.   MOLECULAR PHARMACEUTICS

Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice

(2017) Esther Nuñez-Durán et al.   JOURNAL OF ENDOCRINOLOGY

CENPH Inhibits Rapamycin Sensitivity by Regulating GOLPH3-dependent mTOR Signaling Pathway in Colorectal Cancer

(2017) Wei Wu et al.   Journal of Cancer

The PI3K/AKT Pathway as a Target for Cancer Treatment

(2016) Ingrid A. Mayer et al.   Annual Review of Medicine

Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle

(2016) Urszula Chursa et al.   DIABETOLOGIA

STK25 is a critical determinant in nonalcoholic steatohepatitis

(2016) Manoj Amrutkar et al.   FASEB JOURNAL

Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3

(2016) Su M. Phyu et al.   Scientific Reports

NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth

(2015) Xiaojun Zha et al.   CANCER LETTERS

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

(2015) Masahiro Morita et al.   CELL CYCLE

Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model

(2015) Manoj Amrutkar et al.   DIABETES

Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans

(2015) Manoj Amrutkar et al.   DIABETOLOGIA

Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH

(2015) Manoj Amrutkar et al.   FASEB JOURNAL

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR pathway in colorectal cancer: an update

(2015) Maria Giovanna Francipane et al.   Oncotarget

GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy

(2014) Zaozao Wang et al.   Journal of Translational Medicine

MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect

(2014) L Lin et al.   ONCOGENE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet

(2013) Emmelie Cansby et al.   FASEB JOURNAL

Nutrient regulation of the mTOR Complex 1 signaling pathway

(2013) Sang Gyun Kim et al.   MOLECULES AND CELLS

Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration

(2013) Tohru Matsuki et al.   Neural Development

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

(2012) Ahmed F. Salem et al.   CELL CYCLE

Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle

(2012) A. Nerstedt et al.   DIABETOLOGIA

STK25 Protein Mediates TrkA and CCM2 Protein-dependent Death in Pediatric Tumor Cells of Neural Origin

(2012) Barbara Costa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of SOK1 promotes the migration of MCF-7 cells

(2011) Xu-Dong Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reelin and Stk25 Have Opposing Roles in Neuronal Polarization and Dendritic Golgi Deployment

(2010) Tohru Matsuki et al.   CELL

CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

(2010) Xiangjian Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Serine 58 of 14-3-3  Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

(2009) J. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

(2009) Kenneth L. Scott et al.   NATURE

SOK1 Translocates from the Golgi to the Nucleus upon Chemical Anoxia and Induces Apoptotic Cell Death

(2008) Emilio Nogueira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY