The diverse consequences of aneuploidy

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Cellular Stress Associated with Aneuploidy

(2018) Jin Zhu et al.   DEVELOPMENTAL CELL

Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

(2018) Nadine M. Aziz et al.   Disease Models & Mechanisms

The impact of mitotic errors on cell proliferation and tumorigenesis

(2018) Michelle S. Levine et al.   GENES & DEVELOPMENT

Aneuploidy: Cancer strength or vulnerability?

(2018) Giorgia Simonetti et al.   INTERNATIONAL JOURNAL OF CANCER

Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability

(2018) Cristina Viganó et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Transcriptional Regulation on Aneuploid Chromosomes in Divers Candida albicans Mutants

(2018) Christopher Tucker et al.   Scientific Reports

Emerging Cancer Therapeutic Targets in Protein Homeostasis

(2018) Prabhakar Bastola et al.   AAPS Journal

Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture

(2018) Kristin A. Knouse et al.   CELL

Genome evolution across 1,011 Saccharomyces cerevisiae isolates

(2018) Jackson Peter et al.   NATURE

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast

(2018) Carine Beaupere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of chromosomal instability in cancer progression

(2017) Sarah E McClelland   ENDOCRINE-RELATED CANCER

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9

(2017) Fatwa Adikusuma et al.   MOLECULAR THERAPY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Unresolved recombination intermediates lead to ultra-fine anaphase bridges, chromosome breaks and aberrations

(2017) Ying Wai Chan et al.   NATURE CELL BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

(2017) Teresa Davoli et al.   SCIENCE

Is metal contamination responsible for increasing aneuploidy levels in the Manila clam Ruditapes philippinarum?

(2017) D. Piló et al.   SCIENCE OF THE TOTAL ENVIRONMENT

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

(2017) Laurent Sansregret et al.   Cancer Discovery

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

(2017) Mar Soto et al.   Cell Reports

Aneuploidy in Cancer and Aging

(2016) Ryan M. Naylor et al.   Annual Review of Genetics

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

(2016) Erik McShane et al.   CELL

Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential

(2016) Meili Zhang et al.   EMBO JOURNAL

Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy

(2016) Hong-Yeoul Ryu et al.   GENES & DEVELOPMENT

The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance

(2016) Stacie E. Dodgson et al.   GENES & DEVELOPMENT

Induction of genomic instability and activation of autophagy in artificial human aneuploid cells

(2016) Kentaro Ariyoshi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation

(2016) Edward H. Hinchcliffe et al.   NATURE CELL BIOLOGY

Metastasis as an evolutionary process

(2016) S. Turajlic et al.   SCIENCE

HSF1: Guardian of Proteostasis in Cancer

(2016) Chengkai Dai et al.   TRENDS IN CELL BIOLOGY

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells

(2016) K. M. Godek et al.   Cancer Discovery

The Role of Aneuploidy in Cancer Evolution

(2016) Laurent Sansregret et al.   Cold Spring Harbor Perspectives in Medicine

No current evidence for widespread dosage compensation in S. cerevisiae

(2016) Eduardo M Torres et al.   eLife

Trisomy 21 consistently activates the interferon response

(2016) Kelly D Sullivan et al.   eLife

Constitutive aneuploidy and genomic instability in the single-celled eukaryoteGiardia intestinalis

(2016) Pavla Tůmová et al.   MicrobiologyOpen

Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation

(2016) Tomer Halevy et al.   Stem Cell Reports

Selective advantage of trisomic human cells cultured in non-standard conditions

(2016) Samuel D. Rutledge et al.   Scientific Reports

Whole Chromosome Instability induces senescence and promotes SASP

(2016) Grasiella Angelina Andriani et al.   Scientific Reports

Aneuploidy triggers a TFEB-mediated lysosomal stress response

(2015) Stefano Santaguida et al.   Autophagy

Targeting the Adaptability of Heterogeneous Aneuploids

(2015) Guangbo Chen et al.   CELL

Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells

(2015) Anastasia Y Kuznetsova et al.   CELL CYCLE

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion

(2015) J. K. Meena et al.   EMBO JOURNAL

Aneuploid proliferation defects in yeast are not driven by copy number changes of a few dosage-sensitive genes

(2015) Megan E. Bonney et al.   GENES & DEVELOPMENT

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins

(2015) Alaattin Kaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes

(2015) Z. Holubcova et al.   SCIENCE

Aneuploidy causes premature differentiation of neural and intestinal stem cells

(2015) Delphine Gogendeau et al.   Nature Communications

Cell populations can use aneuploidy to survive telomerase insufficiency

(2015) Caroline Millet et al.   Nature Communications

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

(2015) Akihiro Ohashi et al.   Nature Communications

Enabling High Efficiency Nanoplasmonics with Novel Nanoantenna Architectures

(2015) Moshik Cohen et al.   Scientific Reports

Dosage compensation can buffer copy-number variation in wild yeast

(2015) James Hose et al.   eLife

Chromosome mis-segregation and cytokinesis failure in trisomic human cells

(2015) Joshua M Nicholson et al.   eLife

Unique features of the transcriptional response to model aneuploidy in human cells

(2014) Milena Dürrbaum et al.   BMC GENOMICS

Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum

(2014) K. P. Schoenfelder et al.   DEVELOPMENT

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells

(2014) N. Donnelly et al.   EMBO JOURNAL

Cell cycle population effects in perturbation studies

(2014) E. O'Duibhir et al.   Molecular Systems Biology

Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress

(2014) Floris Foijer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Kinetochore

(2014) I. M. Cheeseman   Cold Spring Harbor Perspectives in Biology

Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells

(2014) Uri Ben-David et al.   Nature Communications

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast

(2014) Noah Dephoure et al.   eLife

A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis

(2013) J. M. Sheltzer   CANCER RESEARCH

Proteotoxic Stress Induces a Cell-Cycle Arrest by Stimulating Lon to Degrade the Replication Initiator DnaA

(2013) Kristina Jonas et al.   CELL

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

Aneuploid yeast strains exhibit defects in cell growth and passage through START

(2013) Rebecca R. Thorburn et al.   MOLECULAR BIOLOGY OF THE CELL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

HSP90 Inhibitors: Current Development and Potential in Cancer Therapy

(2013) Katerina Sidera et al.   Recent Patents on Anti-Cancer Drug Discovery

Self-Correction of Chromosomal Abnormalities in Human Preimplantation Embryos and Embryonic Stem Cells

(2013) Masood Bazrgar et al.   STEM CELLS AND DEVELOPMENT

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Expression of interferon-γ, interferon-α and related genes in individuals with Down syndrome and periodontitis

(2012) Marcia H. Tanaka et al.   CYTOKINE

Aneuploidy causes proteotoxic stress in yeast

(2012) A. B. Oromendia et al.   GENES & DEVELOPMENT

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

(2012) Guangbo Chen et al.   NATURE

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

Causes and consequences of aneuploidy in cancer

(2012) David J. Gordon et al.   NATURE REVIEWS GENETICS

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal duplication is a transient evolutionary solution to stress

(2012) A. H. Yona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

(2011) N. J. Birkbak et al.   CANCER RESEARCH

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Frequent Aneuploidy Among Normal Human Hepatocytes

(2011) Andrew W. Duncan et al.   GASTROENTEROLOGY

Chromosomal mosaicism in human preimplantation embryos: a systematic review

(2011) Jannie van Echten-Arends et al.   HUMAN REPRODUCTION UPDATE

Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

(2011) Kirti Sharma et al.   MOLECULAR & CELLULAR PROTEOMICS

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Oncogenic B-RafV600E Induces Spindle Abnormalities, Supernumerary Centrosomes, and Aneuploidy in Human Melanocytic Cells

(2010) Y. Cui et al.   CANCER RESEARCH

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Genomic Plasticity of the Human Fungal Pathogen Candida albicans

(2010) Anna Selmecki et al.   EUKARYOTIC CELL

Loss of pRB causes centromere dysfunction and chromosomal instability

(2010) A. L. Manning et al.   GENES & DEVELOPMENT

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

A review of trisomy X (47,XXX)

(2010) Nicole R Tartaglia et al.   Orphanet Journal of Rare Diseases

High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability

(2010) A. R. Conery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression in Aneuploid Drosophila S2 Cells

(2010) Yu Zhang et al.   PLOS BIOLOGY

Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts

(2009) Tsutomu Iwamoto et al.   ARCHIVES OF ORAL BIOLOGY

Targeting HSP90 for cancer therapy

(2009) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Drosophila dosage compensation: a complex voyage to the X chromosome

(2009) M. E. Gelbart et al.   DEVELOPMENT

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal instability determines taxane response

(2009) C. Swanton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Buffering of Segmental and Chromosomal Aneuploidies in Drosophila melanogaster

(2009) Per Stenberg et al.   PLoS Genetics

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

(2008) Giulia Rancati et al.   CELL

The consequences of tetraploidy and aneuploidy

(2008) Z. Storchova et al.   JOURNAL OF CELL SCIENCE

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Effects of Aneuploidy on Genome Structure, Expression, and Interphase Organization in Arabidopsis thaliana

(2008) Bruno Huettel et al.   PLoS Genetics