Phosphatidylinositol 4-kinase IIIβ (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins

Isolation and structure–function characterization of a signaling-active rhodopsin–G protein complex

(2017) Yang Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural analysis of phosphatidylinositol 4-kinase IIIβ (PI4KB) – 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro

(2017) Dominika Chalupska et al.   JOURNAL OF STRUCTURAL BIOLOGY

Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1

(2017) Miroslava Alblova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator

(2017) Nikolai N. Sluchanko et al.   STRUCTURE

Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein

(2017) Martin Klima et al.   STRUCTURE

The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3

(2017) Jacob A. McPhail et al.   STRUCTURE

Lipid Tales of Viral Replication and Transmission

(2017) Nihal Altan-Bonnet   TRENDS IN CELL BIOLOGY

Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease

(2016) G. L. Dornan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase IIIβ (PI4KB)

(2016) Jana Humpolickova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

(2016) Florentine U. Rutaganira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology

(2016) Ivana Mejdrová et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sampling Enrichment toward Target Structures Using Hybrid Molecular Dynamics-Monte Carlo Simulations

(2016) Kecheng Yang et al.   PLoS One

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

(2016) Melissa L. Fowler et al.   PROTEIN SCIENCE

Crystal structures of a yeast 14-3-3 protein fromLachancea thermotoleransin the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation

(2016) Andrea Eisenreichova et al.   Acta Crystallographica Section F-Structural Biology Communications

Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein

(2016) Martin Klima et al.   Scientific Reports

Phosphatidylinositol 4-kinases: Function, structure, and inhibition

(2015) Evzen Boura et al.   EXPERIMENTAL CELL RESEARCH

Cellular functions of Rab GTPases at a glance

(2015) Y. Zhen et al.   JOURNAL OF CELL SCIENCE

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action

(2015) Ivana Mejdrová et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

(2015) K. Rostislavleva et al.   SCIENCE

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Solution Structure of the Atg1 Complex: Implications for the Architecture of the Phagophore Assembly Site

(2015) Jürgen Köfinger et al.   STRUCTURE

The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

(2015) Martin Klima et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The crystal structure of the phosphatidylinositol 4-kinase II 

(2014) A. Baumlova et al.   EMBO REPORTS

Large, dynamic, multi-protein complexes: a challenge for structural biology

(2014) Bartosz Różycki et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

A Complex Comprising Phosphatidylinositol 4-Kinase III , ACBD3, and Aichi Virus Proteins Enhances Phosphatidylinositol 4-Phosphate Synthesis and Is Critical for Formation of the Viral Replication Complex

(2014) K. Ishikawa-Sasaki et al.   JOURNAL OF VIROLOGY

Structures of PI4KIII  complexes show simultaneous recruitment of Rab11 and its effectors

(2014) J. E. Burke et al.   SCIENCE

A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

(2013) Hilde M. van der Schaar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cinderella story: PI4P goes from precursor to key signaling molecule

(2013) Julie Tan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Endosomal Sorting Complex Required for Transport (ESCRT) Complexes Induce Phase-separated Microdomains in Supported Lipid Bilayers

(2012) Evzen Boura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4-Kinase IIα Is Palmitoylated by Golgi-localized Palmitoyltransferases in Cholesterol-dependent Manner

(2012) Dongmei Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for membrane targeting by the MVB12-associated  -prism domain of the human ESCRT-I MVB12 subunit

(2012) E. Boura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of the ESCRT-I and -II Supercomplex: Implications for Membrane Budding and Scission

(2012) Evzen Boura et al.   STRUCTURE

Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms

(2012) Nihal Altan-Bonnet et al.   TRENDS IN BIOCHEMICAL SCIENCES

ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites

(2011) Jun Sasaki et al.   EMBO JOURNAL

14-3-3 proteins act as intracellular receptors for rice Hd3a florigen

(2011) Ken-ichiro Taoka et al.   NATURE

Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy

(2011) E. Boura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAXS Ensemble Refinement of ESCRT-III CHMP3 Conformational Transitions

(2011) Bartosz Różycki et al.   STRUCTURE

Structure of the human FOXO4-DBD–DNA complex at 1.9 Å resolution reveals new details of FOXO binding to the DNA

(2010) Evzen Boura et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3)

(2010) Lenka Rezabkova et al.   JOURNAL OF STRUCTURAL BIOLOGY

Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity

(2010) M. Arita et al.   JOURNAL OF VIROLOGY

Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): An emerging signaling molecule

(2010) Jinjiang Fan et al.   PROGRESS IN LIPID RESEARCH

Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIα

(2009) Barbara Barylko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

(2009) J. Borawski et al.   JOURNAL OF VIROLOGY

Charged single α-helix: A versatile protein structural motif

(2008) Dániel Süveges et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Coarse-grained Models for Simulations of Multiprotein Complexes: Application to Ubiquitin Binding

(2007) Young C. Kim et al.   JOURNAL OF MOLECULAR BIOLOGY