The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design

PIPs in neurological diseases

(2015) Mark G. Waugh   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Norbornane-based nucleoside and nucleotide analogues locked in North conformation

(2015) Milan Dejmek et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action

(2015) Ivana Mejdrová et al.   JOURNAL OF MEDICINAL CHEMISTRY

The crystal structure of the phosphatidylinositol 4-kinase II 

(2014) A. Baumlova et al.   EMBO REPORTS

Endosomal sorting of VAMP3 is regulated by PI4K2A

(2014) M. Jovi  et al.   JOURNAL OF CELL SCIENCE

Large, dynamic, multi-protein complexes: a challenge for structural biology

(2014) Bartosz Różycki et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Structures of PI4KIII  complexes show simultaneous recruitment of Rab11 and its effectors

(2014) J. E. Burke et al.   SCIENCE

A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

(2013) Hilde M. van der Schaar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cinderella story: PI4P goes from precursor to key signaling molecule

(2013) Julie Tan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structural Insights into Assembly and Regulation of the Plasma Membrane Phosphatidylinositol 4-Kinase Complex

(2013) Xudong Wu et al.   DEVELOPMENTAL CELL

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Subunit Folds and Maturation Pathway of a dsRNA Virus Capsid

(2013) Daniel Nemecek et al.   STRUCTURE

Handling ligands withCoot

(2012) Judit É. Debreczeni et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila

(2012) J. Burgess et al.   DEVELOPMENT

XDSAPP: a graphical user interface for the convenient processing of diffraction data usingXDS

(2012) Michael Krug et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Phosphatidylinositol 4-Kinases Are Required for Autophagic Membrane Trafficking

(2012) Ke Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal Sorting Complex Required for Transport (ESCRT) Complexes Induce Phase-separated Microdomains in Supported Lipid Bilayers

(2012) Evzen Boura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Structure–Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L

(2012) Justin L. Anglin et al.   JOURNAL OF MEDICINAL CHEMISTRY

The 3A Protein from Multiple Picornaviruses Utilizes the Golgi Adaptor Protein ACBD3 To Recruit PI4KIII 

(2012) A. L. Greninger et al.   JOURNAL OF VIROLOGY

Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase

(2012) Marko Jović et al.   MOLECULAR BIOLOGY OF THE CELL

N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor

(2012) Yaozhong Zou et al.   PLoS One

Structural basis for membrane targeting by the MVB12-associated  -prism domain of the human ESCRT-I MVB12 subunit

(2012) E. Boura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms

(2012) Nihal Altan-Bonnet et al.   TRENDS IN BIOCHEMICAL SCIENCES

Membrane-Elasticity Model of Coatless Vesicle Budding Induced by ESCRT Complexes

(2012) Bartosz Różycki et al.   PLoS Computational Biology

Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

(2012) Annalisa Bianco et al.   PLoS Pathogens

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A homogeneous and nonisotopic assay for phosphatidylinositol 4-kinases

(2011) Andrew W. Tai et al.   ANALYTICAL BIOCHEMISTRY

ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites

(2011) Jun Sasaki et al.   EMBO JOURNAL

Stabilization of Phosphatidylinositol 4-Kinase Type IIβ by Interaction with Hsp90

(2011) Gwanghyun Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the human FOXO4-DBD–DNA complex at 1.9 Å resolution reveals new details of FOXO binding to the DNA

(2010) Evzen Boura et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Membrane Budding

(2010) James H. Hurley et al.   CELL

Multiple Host Proteins That Function in Phosphatidylinositol-4-Phosphate Metabolism Are Recruited to the Chlamydial Inclusion

(2010) A. M. Moorhead et al.   INFECTION AND IMMUNITY

Helicobacter pylori proinflammatory protein up-regulates NF- B as a cell-translocating Ser/Thr kinase

(2010) D. J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl

(2009) Yuanbo Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

(2009) K. L. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIβ

(2008) Gwanghyun Jung et al.   BIOCHEMICAL JOURNAL

Phosphatidylinositol-4-Kinase Type II Alpha Contains an AP-3–sorting Motif and a Kinase Domain That Are Both Required for Endosome Traffic

(2008) Branch Craige et al.   MOLECULAR BIOLOGY OF THE CELL