Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment

(2015) Alberto M. Martelli et al.   Oncotarget

Wild-type EGFR Is Stabilized by Direct Interaction with HSP90 in Cancer Cells and Tumors

(2015) Aarif Ahsan et al.   NEOPLASIA

Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα

(2014) Qiangjun Zhou et al.   Nature Communications

Clinical relevance of the new IASLC/ERS/ATS adenocarcinoma classification

(2013) Keith M Kerr   JOURNAL OF CLINICAL PATHOLOGY

Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET

(2012) L. Xu et al.   CANCER RESEARCH

Phosphatidylinositol 4-Kinase IIα Is Palmitoylated by Golgi-localized Palmitoyltransferases in Cholesterol-dependent Manner

(2012) Dongmei Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs

(2012) V Stresing et al.   ONCOGENE

Gemcitabine Overcomes Erlotinib Resistance in EGFR-Overexpressing Cancer Cells through Downregulation of Akt

(2012) Chandra Bartholomeusz et al.   Journal of Cancer

Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex

(2011) Tushar B. Deb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Histopathologic Characteristics of Lung Adenocarcinomas With Epidermal Growth Factor Receptor Mutations in the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Lung Adenocarcinoma Classification

(2011) Hyo Sup Shim et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Potential mechanism of interleukin-8 production from lung cancer cells: An involvement of EGF-EGFR-PI3K-Akt-Erk pathway

(2011) Yong Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of HER2 in cancer therapy and targeted drug delivery

(2010) Wanyi Tai et al.   JOURNAL OF CONTROLLED RELEASE

PARP-1 inhibitors: a novel genetically specific agents for cancer therapy

(2010) L. Cipak et al.   NEOPLASMA

PI4KIIα is a novel regulator of tumor growth by its action on angiogenesis and HIF-1α regulation

(2010) J Li et al.   ONCOGENE

ESNOQ, Proteomic Quantification of Endogenous S-Nitrosation

(2010) Xixi Zhou et al.   PLoS One

Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis

(2010) K M E Chu et al.   Cell Death & Disease

Quantitative proteomic analysis of S-nitrosated proteins in diabetic mouse liver with ICAT switch method

(2010) Xu Zhang et al.   Protein & Cell

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

(2009) Christina Gewinner et al.   CANCER CELL

Regulation of Phosphatidylinositol Kinases and Metabolism by Wnt3a and Dvl

(2009) Yuanbo Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons

(2009) J. Paul Simons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-EGFR Therapy: Mechanism and Advances in Clinical Efficacy in Breast Cancer

(2009) John F. Flynn et al.   Journal of Oncology

Clinical Efficacy and Toxicity of Anti-EGFR Therapy in Common Cancers

(2009) Amir Harandi et al.   Journal of Oncology

Inhibition of Hsp90 Down-regulates Mutant Epidermal Growth Factor Receptor (EGFR) Expression and Sensitizes EGFR Mutant Tumors to Paclitaxel

(2008) A. Sawai et al.   CANCER RESEARCH

Combined Vascular Endothelial Growth Factor Receptor/Epidermal Growth Factor Receptor Blockade with Chemotherapy for Treatment of Local, Uterine, and Metastatic Soft Tissue Sarcoma

(2008) W. Ren et al.   CLINICAL CANCER RESEARCH

Combined Inhibition of c-Src and Epidermal Growth Factor Receptor Abrogates Growth and Invasion of Head and Neck Squamous Cell Carcinoma

(2008) P. Koppikar et al.   CLINICAL CANCER RESEARCH

ShRNA-mediated Ku80 Gene Silencing Inhibits Cell Proliferation and Sensitizes to γ-radiation and Mitomycin C-induced Apoptosis in Esophageal Squamous Cell Carcinoma Lines

(2008) Qing-Shan YANG et al.   JOURNAL OF RADIATION RESEARCH

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation

(2008) W. Pan et al.   SCIENCE