Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis

Ischemia/reperfusion injury in male guinea pigs: An efficient model to investigate myocardial damage in cardiovascular complications

(2018) Divya Dasagrandhi et al.   BIOMEDICINE & PHARMACOTHERAPY

Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout

(2018) Jun Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

(2018) Xintong Ge et al.   BRAIN RESEARCH

Exosomes derived from embryonic stem cells inhibit doxorubicin and inflammation-induced pyroptosis in muscle cells

(2018) Zahra Tavakoli Dargani et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial InfarctionNovelty and Significance

(2018) Xavier Loyer et al.   CIRCULATION RESEARCH

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tanshinone IIA Attenuates Diabetic Peripheral Neuropathic Pain in Experimental Rats via Inhibiting Inflammation

(2018) Baojian Zhang et al.   Evidence-based Complementary and Alternative Medicine

Stem Cell Therapies in Cardiovascular Disease

(2018) Maia Terashvili et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Hypercapnia induces IL-1β overproduction via activation of NLRP3 inflammasome: implication in cognitive impairment in hypoxemic adult rats

(2018) Hong-Guang Ding et al.   Journal of Neuroinflammation

Evaluation of type 2 diabetic mellitus animal models via interactions between insulin and mitogen‑activated protein kinase signaling pathways induced by a high fat and sugar diet and streptozotocin

(2018) Juncheng Zhuo et al.   Molecular Medicine Reports

Penehyclidine hydrochloride inhibits TLR4 signaling and inflammation, and attenuates blunt chest trauma and hemorrhagic shock-induced acute lung injury in rats

(2018) Xiao‑Jing Wu et al.   Molecular Medicine Reports

Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia

(2018) Paige M. Kulling et al.   PLoS One

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury

(2018) Bjorn T. Tam et al.   Scientific Reports

Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

(2018) Jinyong Wang et al.   PLoS Pathogens

Stem Cell-Derived Exosome in Cardiovascular Diseases: Macro Roles of Micro Particles

(2018) Ye Yuan et al.   Frontiers in Pharmacology

Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis

(2018) Wenting Qu et al.   Frontiers in Immunology

Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease

(2018) Yuan-Yuan Yuan et al.   Gastroenterology Report

PTEN Inhibitor VO-OHpic Attenuates Inflammatory M1 Macrophages and Cardiac Remodeling in Doxorubicin-Induced Cardiomyopathy

(2018) Taylor A. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

(2018) Dandan Li et al.   Molecular Medicine Reports

Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway

(2018) Tianming Qiu et al.   Cell Death & Disease

Role of pyroptosis in cardiovascular disease

(2018) Zeng Zhaolin et al.   CELL PROLIFERATION

NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

(2018) Qun Fu et al.   INFLAMMATION

More Is Less: IL-9 in the Resolution of Inflammation

(2017) Fotios Karagiannis et al.   IMMUNITY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Reactive oxygen species induce injury of the intestinal epithelium during hyperoxia

(2017) Min Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome

(2017) Pei Jiang et al.   Journal of Neuroinflammation

Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights

(2017) Ping-Pin Zheng et al.   MEDICINAL RESEARCH REVIEWS

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

(2017) Simon Rauber et al.   NATURE MEDICINE

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

(2017) Y-L Hsu et al.   ONCOGENE

Interleukin-13 reduces cardiac injury and prevents heart dysfunction in viral myocarditis via enhanced M2 macrophage polarization

(2017) Honghui Yang et al.   Oncotarget

IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice

(2017) Yusuke Shintani et al.   Scientific Reports

Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

(2017) Andrew J. Fleetwood et al.   Frontiers in Cellular and Infection Microbiology

Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid

(2017) Olga Gordeeva et al.   Stem Cells International

IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury

(2017) Weiwei Gao et al.   Frontiers in Neurology

Differential roles of caspase-1 and caspase-11 in infection and inflammation

(2017) Si Ming Man et al.   Scientific Reports

Stem cells and exosomes in cardiac repair

(2016) Dinender K Singla   CURRENT OPINION IN PHARMACOLOGY

Oxidative stress does not play a primary role in the toxicity induced with clinical doses of doxorubicin in myocardial H9c2 cells

(2016) Tareck Rharass et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

(2016) Wen-Shan Gui et al.   Molecular Pain

Characterization of Cell-Type-Specific Drug Transport and Resistance of Breast Cancers Using Tumor-Microenvironment-on-Chip

(2016) Kyeonggon Shin et al.   MOLECULAR PHARMACEUTICS

Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4

(2016) J Xiao et al.   Cell Death & Disease

The gasdermin-D pore: Executor of pyroptotic cell death

(2016) Sebastian Rühl et al.   Oncotarget

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

(2016) Agnes Maillet et al.   Scientific Reports

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Akt—mTOR Pathway Inhibits Apoptosis and Fibrosis in Doxorubicin-Induced Cardiotoxicity following Embryonic Stem Cell Transplantation

(2015) Dinender K. Singla   CELL TRANSPLANTATION

Embryonic Stem Cells and Released Factors Stimulate c-kit+/FLK-1+ Progenitor Cells and Promote Neovascularization in Doxorubicin-Induced Cardiomyopathy

(2015) Dinender K. Singla et al.   CELL TRANSPLANTATION

Exosomes as Potential Alternatives to Stem Cell Therapy in Mediating Cardiac Regeneration

(2015) S.-G. Ong et al.   CIRCULATION RESEARCH

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

Exosomes in cancer: small particle, big player

(2015) Xu Zhang et al.   Journal of Hematology & Oncology

An Excess of the Proinflammatory Cytokines IFN-γ and IL-12 Impairs the Development of the Memory CD8+T Cell Response toChlamydia trachomatis

(2015) Xuqing Zhang et al.   JOURNAL OF IMMUNOLOGY

Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB

(2015) Silvia Alfonso-Loeches et al.   NEUROCHEMICAL RESEARCH

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Interleukin-13 Deficiency Aggravates Healing and Remodeling in Male Mice After Experimental Myocardial Infarction

(2014) Ulrich Hofmann et al.   Circulation-Heart Failure

Exosomes Derived from Mesenchymal Stem Cells

(2014) Bo Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential Lymphocyte and Antibody Responses in Deer Mice Infected with Sin Nombre Hantavirus or Andes Hantavirus

(2014) T. Schountz et al.   JOURNAL OF VIROLOGY

Notch-1 Mediated Cardiac Protection following Embryonic and Induced Pluripotent Stem Cell Transplantation in Doxorubicin-Induced Heart Failure

(2014) Hilda Merino et al.   PLoS One

A Chitin-Like Component on Sclerotic Cells of Fonsecaea pedrosoi Inhibits Dectin-1-Mediated Murine Th17 Development by Masking β-Glucans

(2014) Bilin Dong et al.   PLoS One

Novel method for extracting exosomes of hepatocellular carcinoma cells

(2014) Lin Zhu   WORLD JOURNAL OF GASTROENTEROLOGY

Heart Transplantation: Challenges Facing the Field

(2014) M. Tonsho et al.   Cold Spring Harbor Perspectives in Medicine

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy

(2014) Piyali Chatterjee et al.   Frontiers in Immunology

Isorhamnetin Protects against Doxorubicin-Induced Cardiotoxicity In Vivo and In Vitro

(2013) Jing Sun et al.   PLoS One

Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination

(2013) Nao Jounai et al.   Frontiers in Cellular and Infection Microbiology

Mechanisms of Cell Death in Heart Disease

(2012) Klitos Konstantinidis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Embryonic Stem Cells Improve Cardiac Function in Doxorubicin-Induced Cardiomyopathy Mediated through Multiple Mechanisms

(2012) Dinender K. Singla et al.   CELL TRANSPLANTATION

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle

(2011) Ashley J. Smuder et al.   JOURNAL OF APPLIED PHYSIOLOGY

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Doxorubicin pathways

(2010) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Direct effects of doxorubicin on skeletal muscle contribute to fatigue

(2009) K van Norren et al.   BRITISH JOURNAL OF CANCER

Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies

(2009) Masahiro Kondo et al.   IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway

(2008) Dinender K. Singla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Inflammatory Response to Cell Death

(2008) Kenneth L. Rock et al.   Annual Review of Pathology-Mechanisms of Disease

Activation of Toll-Like Receptor 4 (TLR4) by In Vivo and In Vitro Exposure of Rat Epididymis to Lipopolysaccharide from Escherichia Coli1

(2008) Alexandre Rodrigues et al.   BIOLOGY OF REPRODUCTION

Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy

(2007) Xu-Jun Qin et al.   JOURNAL OF APPLIED TOXICOLOGY