Article
Cell Biology
Pengcheng Yan, Xiaoning Song, Joanne Tran, Runfa Zhou, Xinran Cao, Gang Zhao, Haitao Yuan
Summary: This study found that dapagliflozin has a protective effect on viral myocarditis by alleviating myocardial inflammation and improving cardiac function. It also activates the Stat3 signaling pathway to promote anti-inflammatory macrophage polarization and reduce cardiac injury.
Article
Cell Biology
Pengcheng Yan, Xiaoning Song, Joanne Tran, Runfa Zhou, Xinran Cao, Gang Zhao, Haitao Yuan
Summary: Dapagliflozin has a protective effect on viral myocarditis, reducing its severity, improving survival rate, and ameliorating cardiac function. It decreases pro-inflammatory cytokines levels, inhibits macrophage differentiation to M1 phenotype, and activates the polarization of M2 phenotype through the Stat3 signal pathway.
Article
Immunology
Yanhao Zhang, Feng Yang, Dong Sun, Limin Xu, Yaojia Shi, Leilei Qin, Liqun Zhao, Liting Wang, Wei Sun, Hongri Wu, Dongshui Lu, Weijun Zhang, Ping Luo, Ping Cheng, Quanming Zou, Hao Zeng
Summary: This study reports the protective effects of a recombinant five-antigen S. aureus vaccine in an S. aureus infected bone defect model. The study found that the number of M2 macrophages increased significantly in the defect site and played a critical role in the healing process mediated by the vaccine.
CLINICAL IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yan Zhang, Shengbao Cai, Xiaoxue Ding, Can Lu, Ruodan Wu, Haiyan Wu, Yiyi Shang, Mingjie Pang
Summary: In this study, it was discovered that inhibition of miR-30a-5p may improve cardiac injury following viral myocarditis by promoting M2 polarization of macrophages via SOCS1 upregulation. The anti-inflammatory mechanisms of miR-30a-5p inhibition could potentially lead to the development of new therapeutic strategies for viral myocarditis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yucheng Wang, Minghui Li, Jun Chen, Ying Yu, Yong Yu, Hui Shi, Xiaoxiao Liu, Zhiwei Chen, Ruizhen Chen, Junbo Ge
Summary: This study investigated the regulatory role of macrophage CAPN4 in coxsackievirus B3 (CVB3)-induced myocarditis. The results suggest that CAPN4 promotes M1 macrophage polarization and NLRP3 inflammasome activation, leading to myocardial inflammation and injury in CVB3 infection.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Chen Chen, Jianan Ma, Chenchen Pi, Wei Huang, Tao Zhang, Cong Fu, Wentao Liu, Yong-Guang Yang
Summary: IL-10(+) regulatory B cells (Bregs) are important in cancer immunotherapy with PPAR delta playing a significant role in their development and function. In this study, PPAR delta was found to be upregulated in tumor-induced IL-10(+) Bregs, and its expression level was correlated with IL-10 production and T cell inhibition. Genetic inactivation of PPAR delta impaired IL-10(+) Breg development and function, while treatment with a PPAR delta inhibitor reduced their induction. Immunotherapy with CD40 or PD1 antibodies had improved outcomes in tumor-bearing mice with PPAR delta deficiency or treated with a PPAR delta inhibitor.
Article
Biochemistry & Molecular Biology
Shuaini Yang, Jiajia Zeng, Wenlian Hao, Ruoyuan Sun, Yuqing Tuo, Lu Tan, Hong Zhang, Ran Liu, Hong Bai
Summary: This study investigated the relationship between interleukin-21 receptor (IL-21R) and macrophages (M phi) in chlamydial lung infection. The results showed that IL-21R deficiency led to decreased M phi infiltration and impaired inflammatory response. In vitro experiments also revealed the proinflammatory effect of IL-21 on macrophages. These findings contribute to our understanding of how IL-21R exacerbates chlamydia respiratory infection by promoting the proinflammatory effect of M phi.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kathrine Gotfredsen, Charlotte Liisborg, Vibe Skov, Lasse Kjaer, Hans Carl Hasselbalch, Torben Lykke Sorensen
Summary: Immune responses play a key role in the pathogenesis and progression of MPN and AMD. This study found that serum levels of IL-4 and IL-33 may be involved in drusen development in MPN patients, supporting the association between chronic inflammation and drusen.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Boxing Su, Haibo Han, Yanqing Gong, Xuesong Li, Chaoyue Ji, Jingjing Yao, Jianghui Yang, Weiguo Hu, Wei Zhao, Jianxing Li, Gang Zhang, Liqun Zhou
Summary: Let-7d inhibits intratumoral macrophage M2 polarization and tumor angiogenesis in RCC by targeting IL-10 and IL-13.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Allergy
Yuting Tang, Qian Xu, Hui Luo, Xiaomei Yan, Gaoxiang Wang, Liang Hu, Jin Jin, David P. Witte, Rebecca A. Marsh, Liang Huang, Gang Huang, Jianfeng Zhou
Summary: This study found that the collaborative roles of IL-10 and IL-18 can drive a hyperinflammatory syndrome similar to hemophagocytic lymphohistiocytosis (HLH). The study also discovered that blocking IL-10 can be protective in patients with HLH.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yimin Huang, Kongyang Ma, Rencai Qin, Yaxiong Fang, Jingquan Zhou, Xiaoyan Dai
Summary: This study found that pristane can decrease atherosclerotic lesion formation and increase stability of plaques, while inhibiting the frequency of B cells and increasing the frequency of plasma cells and M2 macrophages. Pristane induces IL-4-producing CD138+ regulatory plasma cell generation, which promotes M2 macrophage polarization via IL-4 secretion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Victor D. Cuevas, Miriam Simon-Fuentes, Emmanuel Orta-Zavalza, Rafael Samaniego, Paloma Sanchez-Mateos, Maria Escribese, Francisco J. Cimas, Matilde Bustos, Mario Perez-Diego, Alberto Ocana, Angeles Dominguez-Soto, Miguel A. Vega, Angel L. Corbi
Summary: During inflammatory responses, monocytes can differentiate into monocyte-derived macrophages with distinct transcriptional profiles, which are partially regulated by IL-10. This specific gene expression signature may provide potential targets for macrophage-centered therapeutic strategies.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Dominik Klaver, Hubert Gander, Gabriele Dobler, Andrea Rahm, Martin Thurnher
Summary: This study reveals how P2Y(11) utilizes IL-1R and canonical signaling pathways to promote the anti-inflammatory and pro-angiogenic properties of human M2 macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Ming-Kai Jhan, Chia-Ling Chen, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Rahmat Dani Satria, Chia-Yi Yu, Chiou-Feng Lin
Summary: Infection with flaviviruses can lead to neuronal damage and infiltration of inflammatory cells, resulting in viral encephalitis. Studies have shown that this is associated with polarization of M1 macrophages in the brain.
Article
Immunology
Yanxiang Hu, Jing Wen, Bei Zhang, Hui Xiao
Summary: The TSC1-mTOR pathway plays a crucial role in regulating the homeostasis and functional specification of alveolar macrophages (AMs) by integrating cytokine signaling with metabolic cues. Genetic ablation of TSC1 or mTOR genes in AMs resulted in a decrease in AM numbers in mice, indicating the pathway is a key regulatory mechanism for AMs. Disruption of the pathway led to an increase in cell death and altered cytokine signaling, affecting the survival and development of the cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
