Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

Porphyromonas gingivalis Promotes Unrestrained Type I Interferon Production by Dysregulating TAM Signaling via MYD88 Degradation

(2017) Gabriel Mizraji et al.   Cell Reports

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals

(2016) Jelena S Bezbradica et al.   Cellular & Molecular Immunology

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage

(2016) Beáta Németh et al.   FASEB JOURNAL

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Porphyromonas gingivalis Outer Membrane Vesicles Induce Selective Tumor Necrosis Factor Tolerance in a Toll-Like Receptor 4- and mTOR-Dependent Manner

(2016) Tobias Waller et al.   INFECTION AND IMMUNITY

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge:Mycobacterium tuberculosisInduces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication

(2016) Laura E. Gleeson et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

(2016) Jessica D. Cecil et al.   PLoS One

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis

(2016) Roselind S. Lam et al.   PLoS One

Nucleoside-Diphosphate-Kinase of P. gingivalis is Secreted from Epithelial Cells In the Absence of a Leader Sequence Through a Pannexin-1 Interactome

(2016) Kalina Atanasova et al.   Scientific Reports

Contradictory roles ofPorphyromonas gingivalisgingipains in caspase-1 activation

(2015) Young-Jung Jung et al.   CELLULAR MICROBIOLOGY

Biogenesis and function ofPorphyromonas gingivalisouter membrane vesicles

(2015) H Xie   Future Microbiology

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System

(2015) Andrew J. Fleetwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection

(2015) E.S. Ramos-Junior et al.   JOURNAL OF DENTAL RESEARCH

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Porphyromonas gingivalis attenuates ATP-mediated inflammasome activation and HMGB1 release through expression of a nucleoside-diphosphate kinase

(2015) Larry Johnson et al.   MICROBES AND INFECTION

Spheres of influence:Porphyromonas gingivalisouter membrane vesicles

(2015) M.J. Gui et al.   Molecular Oral Microbiology

Strain- and host species-specific inflammasome activation, IL-1β release and cell death in macrophages infected with uropathogenic Escherichia coli

(2015) K Schaale et al.   Mucosal Immunology

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity

(2015) Özlem Yilmaz et al.   PERIODONTOLOGY 2000

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

(2015) Jan Van den Bossche et al.   Jove-Journal of Visualized Experiments

Functional Advantages of Porphyromonas gingivalis Vesicles

(2015) Meng-Hsuan Ho et al.   PLoS One

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porphyromonas gingivalis Fimbriae Dampen P2X7-Dependent Interleukin-1β Secretion

(2014) Ana Carolina Morandini et al.   Journal of Innate Immunity

Porphyromonas gingivalis Outer Membrane Vesicles Exclusively Contain Outer Membrane and Periplasmic Proteins and Carry a Cargo Enriched with Virulence Factors

(2014) Paul D. Veith et al.   JOURNAL OF PROTEOME RESEARCH

The inflammophilic character of the periodontitis-associated microbiota

(2014) G. Hajishengallis   Molecular Oral Microbiology

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

A Novel Approach for Purification and Selective Capture of Membrane Vesicles of the Periodontopathic Bacterium, Porphyromonas gingivalis: Membrane Vesicles Bind to Magnetic Beads Coated with Epoxy Groups in a Noncovalent, Species-Specific Manner

(2014) Ryoma Nakao et al.   PLoS One

Distinct Lipid A Moieties Contribute to Pathogen-Induced Site-Specific Vascular Inflammation

(2014) Connie Slocum et al.   PLoS Pathogens

Fimbriae-mediated outer membrane vesicle production and invasion ofPorphyromonas gingivalis

(2014) Chinmay K. Mantri et al.   MicrobiologyOpen

Metabolic control of dendritic cell activation and function: recent advances and clinical implications

(2014)   Frontiers in Immunology

Porphyromonas gingivalis downregulates the immune response of fibroblasts

(2013) Eleonor Palm et al.   BMC MICROBIOLOGY

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection

(2013) Eunjoo Park et al.   INFECTION AND IMMUNITY

How Metabolism Generates Signals during Innate Immunity and Inflammation

(2013) Anne F. McGettrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

(2013) Shu-Chen Hung et al.   PLoS One

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7receptor/NADPH-oxidase signalling and contributes to persistence

(2012) Chul Hee Choi et al.   CELLULAR MICROBIOLOGY

Porphyromonas gingivalisMediates Inflammasome Repression in Polymicrobial Cultures through a Novel Mechanism Involving Reduced Endocytosis

(2012) Debra J. Taxman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbial Carriage State of Peripheral Blood Dendritic Cells (DCs) in Chronic Periodontitis Influences DC Differentiation, Atherogenic Potential

(2012) J. Carrion et al.   JOURNAL OF IMMUNOLOGY

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

The keystone-pathogen hypothesis

(2012) George Hajishengallis et al.   NATURE REVIEWS MICROBIOLOGY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin

(2011) P Kelk et al.   Cell Death & Disease

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles

(2010) T. N. Ellis et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Periodontitis: a polymicrobial disruption of host homeostasis

(2010) Richard P. Darveau   NATURE REVIEWS MICROBIOLOGY

NO production in RAW264 cells stimulated with Porphyromonas gingivalis extracellular vesicles

(2010) R Imayoshi et al.   ORAL DISEASES

Microbial Hijacking of Complement-Toll-Like Receptor Crosstalk

(2010) M. Wang et al.   Science Signaling

ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected byPorphyromonas gingivalis

(2009) Özlem Yilmaz et al.   CELLULAR MICROBIOLOGY

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases

(2009) N. Bostanci et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Critical Role of Apoptotic Speck Protein Containing a Caspase Recruitment Domain (ASC) and NLRP3 in Causing Necrosis and ASC Speck Formation Induced by Porphyromonas gingivalis in Human Cells

(2009) M. T.-H. Huang et al.   JOURNAL OF IMMUNOLOGY

Targeting of DC-SIGN on Human Dendritic Cells by Minor Fimbriated Porphyromonas gingivalis Strains Elicits a Distinct Effector T Cell Response

(2009) A. E. Zeituni et al.   JOURNAL OF IMMUNOLOGY

The generation and properties of human macrophage populations from hemopoietic stem cells

(2009) Kerrie J. Way et al.   JOURNAL OF LEUKOCYTE BIOLOGY

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

(2009) Andrew J. Fleetwood et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metal uptake in host–pathogen interactions: role of iron in Porphyromonas gingivalis interactions with host organisms

(2009) Janina P. Lewis   PERIODONTOLOGY 2000

Progression of chronic periodontitis can be predicted by the levels ofPorphyromonas gingivalisandTreponema denticolain subgingival plaque

(2009) S. J. Byrne et al.   Oral microbiology and immunology

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Lipid raft-dependent uptake, signalling and intracellular fate ofPorphyromonas gingivalisin mouse macrophages

(2008) Min Wang et al.   CELLULAR MICROBIOLOGY

Porphyromonas gingivalis culture supernatants differentially regulate Interleukin-1β and Interleukin-18 in human monocytic cells

(2008) M. Hamedi et al.   CYTOKINE

Porphyromonas gingivalis RgpA-Kgp Proteinase-Adhesin Complexes Penetrate Gingival Tissue and Induce Proinflammatory Cytokines or Apoptosis in a Concentration-Dependent Manner

(2008) N. M. O'Brien-Simpson et al.   INFECTION AND IMMUNITY

The host cytokine response toPorphyromonas gingivalisis modified by gingipains

(2008) P. G. Stathopoulou et al.   Oral microbiology and immunology