Article
Biology
Simone Filardo, Marisa Di Pietro, Federica Frasca, Fabiana Diaco, Mirko Scordio, Guido Antonelli, Carolina Scagnolari, Rosa Sessa
Summary: The study found that IFN-gamma inhibits the inflammasome network in C. trachomatis-infected synovial cells by downregulating caspase-1 mRNA expression, revealing how the bacterium hinders the inflammasome pathway for intracellular survival.
Article
Biology
Nadine Vollmuth, Lisa Schlicker, Yongxia Guo, Pargev Hovhannisyan, Sudha Janaki-Raman, Naziia Kurmasheva, Werner Schmitz, Almut Schulze, Kathrin Stelzner, Karthika Rajeeve, Thomas Rudel, Sophie Helaine
Summary: IFN-γ downregulates c-Myc to activate L-tryptophan metabolism, leading to persistent Chlamydia trachomatis infection. Additionally, tryptophan concentration controls c-Myc levels via the PI3K-GSK3β axis, and results in the rewiring of the host cell tricarboxylic acid cycle.
Article
Microbiology
Nadja Kading, Nis Schmidt, Celeste Scholz, Simon Graspeuntner, Jan Rupp, Kensuke Shima
Summary: Research indicates that azithromycin (AZM) is less effective than doxycycline (DOX) in treating Chlamydia trachomatis infection, which may be related to the metabolic status of host cells. AZM fails to effectively suppress host cell metabolic pathways, leading to chlamydial reactivation and induced cytokine responses. Further studies are needed to elucidate its functional relevance and impact on disease progression.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhenjie Sun, Yumeng Li, Hui Chen, Lijuan Xie, Jian Xiao, Xiuli Luan, Bo Peng, Zhongyu Li, Lili Chen, Chuan Wang, Chunxue Lu
Summary: The study showed that C. trachomatis glycogen synthase (GlgA) induces IL-8, IL-1 β, and TNF-α expression in THP-1 cells through TLR2, TLR4, and MAPK/NF-kappa B pathways. Blocking these pathways resulted in reduced secretion of these cytokines, indicating a potential mechanism for inflammation during C. trachomatis infection.
Article
Multidisciplinary Sciences
Lion F. K. Uhl, Han Cai, Sophia L. Oram, Jagdish N. Mahale, Andrew J. Maclean, Julie M. Mazet, Theo Piccirilli, Alexander J. He, Doreen Lau, Tim Elliott, Audrey Gerard
Summary: This study found that interferon-gamma (IFN-γ) coordinates the affinity and differentiation of CD8(+) T cells during infection. IFN-γ promotes the expansion of low-affinity T cells, allowing them to compete with high-affinity T cells, while also enhancing the entry of high-affinity T cells into the memory cell pool. IFN-γ is mainly provided by virtual memory T cells, a subset of T cells with memory features but without antigen experience.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Lang Jiang, Lu Liu, Miaomiao Zhang, Linxia Zhang, Cuisong Zhu, Qian He, Lilin Ye, Chen Zhao, Zejun Li, Jianqing Xu, Xiaoyan Zhang
Summary: Research has shown that CD8+ lung tissue resident memory T (T-RM) cells play a crucial role in protecting against respiratory viruses. By studying mouse infection models, it was found that lung CD8+ T-RM cells can quickly respond to antigen re-exposure and induce interferon-stimulated genes (ISGs) in the surrounding tissues. The study also revealed that the induction of certain important antiviral ISGs and the suppression of key inflammatory cytokines are dependent on IFN-gamma signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Diego Del Balzo, Anahi Capmany, Ignacio Cebrian, Maria Teresa Damiani
Summary: This study reveals that Chlamydia trachomatis can induce productive infections in murine dendritic cells and disrupt MHC-I trafficking, leading to impaired antigen cross-presentation ability.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Guangming Zhong
Summary: Research findings suggest that Chlamydia trachomatis plays a significant role in genital tract pathogenicity but can also colonize the gastrointestinal tract for extended periods. Plasmid and chromosome-encoded factors have varying importance in colonization of different parts of the GI tract, playing crucial roles in the spread and colonization of Chlamydia.
TRENDS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ankita Ray, Tanu Bhati, Renu Arora, Sangita Rastogi
Summary: This study evaluated the expression and correlation of miRNAs and cytokines in C. trachomatis-positive spontaneous aborters. The results showed that miR-133a and 101-3p were upregulated and positively correlated with chlamydial load in the infected group. Additionally, progesterone levels were significantly decreased and cytokines (IL-6, IFN-gamma, TNF-alpha) were significantly upregulated in C. trachomatis-positive patients. Positive correlation was observed between the expression of miR-133a and 101-3p and cytokines, while negative correlation was observed with progesterone in infected RSA patients. Evaluating the association between C. trachomatis infection and recurrent spontaneous abortion is of clinical importance for diagnosis and treatment.
MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chiara Ciminieri, Manon E. Woest, Niki L. Reynaert, Irene H. Heijink, Rene Wardenaar, Diana C. J. Spierings, Corry-Anke Brandsma, Melanie Konigshoff, Reinoud Gosens
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by persistent inflammation and defective tissue repair in the lungs. This study aimed to investigate the impact of the inflammatory microenvironment on epithelial progenitors and their supporting mesenchymal niche cells in distal lung tissue repair. IL-1 beta, an inflammatory mediator increased during COPD exacerbations, was found to alter the state of fibroblasts and switch their function from supportive to inhibitory in an organoid assay. Targeting IL-1 beta intracellular signaling or C-X-C chemokine receptors 1/2 (CXCR1/2) reduced the proinflammatory response and restored organoid growth. These findings suggest that chronic inflammation contributes to the inhibition of repair in COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Bojana Jakic, William J. Olson, Kerstin Siegmund, Victoria Klepsch, Janine Kimpel, Verena Labi, Dietmar Zehn, Gottfried Baier, Natascha Hermann-Kleiter
Summary: The loss of nuclear orphan receptor NR2F6 enhances antigen-specific CD8(+) memory formation and boosts inflammatory cytokine responses in mice after bacterial infection. The enhanced memory formation is intrinsic to CD8(+) T cells and is established early in the antibacterial immune response, mediated by IFN-gamma. Blocking IFN-gamma normalizes the memory precursor cell formation, indicating potential therapeutic benefits of NR2F6 manipulation for memory CD8(+) T cell functionality.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Saicheng Zhang, Yuki Funahashi, Satoho Tanaka, Torahiko Okubo, Jeewan Thapa, Shinji Nakamura, Hideaki Higashi, Hiroyuki Yamaguchi
Summary: The presence of indole, a precursor of tryptophan, enables Chlamydia trachomatis (Ct) to infect cells exposed to interferon-y (IFN-y). Indole and other aryl hydrocarbon receptor (AhR) ligands inhibit Ct growth, especially under normal oxygen conditions. Ct growth relies on the scavenger role of cytosolic AhR responsible for promoting the expression of detyrosinated tubulin. (c) 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
MICROBES AND INFECTION
(2023)
Article
Medicine, General & Internal
Mojtaba Norouzi, Majid Pirestani, Ehsan Arefian, Abdolhossein Dalimi, Javid Sadraei, Hamed Mirjalali
Summary: This study is the first to report the release of exosome-like vesicles by the human parasite Blastocystis, demonstrating the role of this parasite, particularly ST1, in proinflammatory and anti-inflammatory cytokines and modulating the host response.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Elvia Perez-Soto, Eduardo Fernandez-Martinez, Rigoberto Oros-Pantoja, Olivia Medel-Flores, Jose Cruz Miranda-Covarrubias, Virginia Sanchez-Monroy
Summary: Infection with HPV or HPV + CT can impact sperm quality and induce inflammation and oxidative stress in asymptomatic infertile men, potentially compromising male fertility. Conversely, infection with CT may alter the state of oxidative stress by promoting an alkaline pH in the semen.
MEDICINA-LITHUANIA
(2021)
Article
Oncology
Catherine S. Forconi, David H. Mulama, Priya Saikumar Lakshmi, Joslyn Foley, Juliana A. Otieno, Jonathan D. Kurtis, Leslie J. Berg, John M. Ong'echa, Christian Muenz, Ann M. Moormann
Summary: Children diagnosed with endemic Burkitt lymphoma (eBL) show deficient IFN-? responses to EBNA1, but the specific contributions of immune-regulatory cytokines and EBNA1-specific T cell phenotypes have not been clearly characterized. Our study compared cytokine expression and T cell memory profiles in response to EBNA1 and a malaria antigen among eBL patients and healthy children with different malaria exposures. Results indicate that eBL children have lower rates of EBNA1-specific IFN-? producing CD4(+) T cells compared to healthy children with high or low malaria exposures.