Review
Biochemistry & Molecular Biology
T. G. Sahana, Ke Zhang
Summary: Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease with multiple genetic and non-genetic risk factors. Cellular stress plays a significant role in ALS conditions, with the MAPK pathway being implicated in the disease pathogenesis and potential drug targeting.
Article
Biochemistry & Molecular Biology
Jin Hee Kim, In Gyoung Ju, Namkwon Kim, Eugene Huh, So-Ri Son, Joon Pyo Hong, Yujin Choi, Dae Sik Jang, Myung Sook Oh
Summary: This study aimed to investigate the anti-neuroinflammatory effects of yomogin, isolated from Artemisia iwayomogi. The results showed that yomogin suppressed neuroinflammatory factors and regulated the MAPK pathway, suggesting its potential as a therapeutic candidate for inflammation-mediated neurological diseases.
Review
Gastroenterology & Hepatology
Qi Chen, Jiayu Guo, Tao Qiu, Jiangqiao Zhou
Summary: Since the discovery of apoptosis signal-regulated kinase 1 (ASK1), its signal transduction mechanism and pathophysiological process have been revealed. ASK1 plays a critical role in the development of diseases affecting various systems, such as nervous, cardiac, and renal. It mediates apoptosis, necrosis, inflammation, and other pathological processes through its downstream JNK/p38 MAPK. The increasing number of studies focusing on the role of ASK1 in liver-related diseases highlights its importance in liver disease development.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Endocrinology & Metabolism
Matthaeus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Scherer
Summary: In this study, the role of brain insulin signaling in regulating lipolysis was further characterized. It was found that intact hypothalamic MAPK signaling is required for insulin to suppress adipose tissue lipolysis.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Wei Wei, Wei Zou, Wei Han
Summary: This study demonstrates that overexpression of Serpin B1 can alleviate lupus nephritis, possibly through the involvement of the MAPK pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Food Science & Technology
Ping Tang, Xinzhou Yang, Huijian Chen, Ting Zhang, Hui Tang, Kejian Pang
Summary: This study demonstrates the antidiabetic activity of ethyl acetate extract of Morus nigra L. twigs (MNT-EA) and its potential mechanisms through the activation of AMPK/PKC/GLUT4 signaling pathway, which enhances glucose uptake and improves diabetic symptoms.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mary Priyanka Udumula, Sureshbabu Mangali, Jaspreet Kalra, Deepika Dasari, Srashti Goyal, Vandana Krishna, Srivarsha Reddy Bollareddy, Dharamrajan Sriram, Arti Dhar, Audesh Bhat
Summary: Metabolic disorders in young population are increasing due to dietary habits and lack of physical activity. The study investigated the role of PKR pathway in diabetes induced by high fructose and streptozotocin, and found that PKR inhibitor could attenuate the impairments caused by high fructose and streptozotocin. Inhibition of PKR can protect insulin sensitive organs and tissues from diabetic impairments induced by high fructose.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yafei Zhou, Ying Xie, Tao Li, Peng Zhang, Tangting Chen, Zhongcai Fan, Xiaoqiu Tan
Summary: This study demonstrates that PAK1 is involved in AngII-induced proliferation, migration and transdifferentiation of cardiac fibroblasts through the JNK/c-Jun pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Shu-qing Ma, Zhen Guo, Fang-yuan Liu, Shahzad-Gul Hasan, Dan Yang, Nan Tang, Peng An, Ming-yu Wang, Hai-ming Wu, Zheng Yang, Di Fan, Qi-zhu Tang
Summary: The study demonstrates that 6-gingerol can protect against pressure overload-induced cardiac remodeling in in vivo models by improving cardiac function and alleviating hypertrophy, fibrosis, inflammation, and dysfunction. In vitro experiments showed that 6-gingerol can block cardiomyocyte hypertrophy and cardiac fibroblast activation in response to specific stimuli.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Medicine, Research & Experimental
Lulu Zhang, Chunmei Yang, Yanran Huang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yuping Wang, Xiaoji Luo, Jinyong Luo
Summary: The study demonstrates that Cardamonin inhibits proliferation, migration, and invasion of osteosarcoma cells, inducing cell cycle arrest. It has minimal effects on normal cells and represses tumor growth in a xenograft mouse model. Mechanistically, Cardamonin activates the P38 and JNK MAPK signaling pathway to promote apoptosis in osteosarcoma cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Zan Zhang, Qiming Chen, Luting Jia, Ming Qian, Qinghai Qiao, Xiaosan Huang, Shaoling Zhang
Summary: This study identified eight putative PbrMAPKK genes from the Chinese white pear genome, which were divided into A, B, C, and D groups. Seven candidate genes associated with resistance were identified through qRT-PCR analysis. Virus-induced gene silencing experiment indicated that PbrMAPKK6 gene enhanced resistance to pear black spot disease.
HORTICULTURAL PLANT JOURNAL
(2023)
Article
Endocrinology & Metabolism
Ravi Prakash, Tripti Mishra, Kapil Dev, Kriti Sharma, Jitendra Kuldeep, Aijaz Ahmad John, Alok Tripathi, Chetan Sharma, Kamal Ram Arya, Brijesh Kumar, Mohd Imran Siddiqi, Narender Tadigoppula, Divya Singh
Summary: This study investigated the mechanism by which coelogin stimulates osteoblastogenesis and its effects on osteoprotection and bone regeneration. Results showed that coelogin treatment led to increased osteoblast proliferation, survival, differentiation, and mineralization in osteoblast cells, and promoted new bone formation and prevented bone deterioration in osteopenic mice. Signaling studies revealed that coelogin activates the ER-Erk and Akt-dependent pathways to stimulate osteoblastogenesis.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Chemistry, Multidisciplinary
Ratnadwip Singha, Fang Yuan, Guangming Cheng, Tyger H. Salters, Yuzki M. Oey, Graciela V. Villalpando, Milena Jovanovic, Nan Yao, Leslie M. Schoop
Summary: TaCo2Te2 is a new air-stable, high-mobility magnetic vdW material with metallic character and large, nonsaturating anisotropic magnetoresistance. It adopts a layered structure consisting of Peierls distorted Co chains and large vdW gap.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Letter
Surgery
JunYa Zhu, Kun Lv, Lei Jiang, Nan Yao
ASIAN JOURNAL OF SURGERY
(2022)
Article
Chemistry, Physical
Fang Yuan, Xiaoyu Song, Guangming Cheng, Nan Yao, Yurij Mozharivskyj, Leslie M. Schoop
Summary: Two chemical routes are reported for the preparation of magnetically doped two-dimensional tin sulfides, with the resulting nanosheets exhibiting magnetic saturation in a moderate field. These new materials may find applications in 2D magnetism, catalysis, or batteries.
CHEMISTRY OF MATERIALS
(2022)
Article
Multidisciplinary Sciences
Ilya Belopolski, Guoqing Chang, Tyler A. Cochran, Zi-Jia Cheng, Xian P. Yang, Cole Hugelmeyer, Kaustuv Manna, Jia-Xin Yin, Guangming Cheng, Daniel Multer, Maksim Litskevich, Nana Shumiya, Songtian S. Zhang, Chandra Shekhar, Niels B. M. Schroeter, Alla Chikina, Craig Polley, Balasubramanian Thiagarajan, Mats Leandersson, Johan Adell, Shin-Ming Huang, Nan Yao, Vladimir N. Strocov, Claudia Felser, M. Zahid Hasan
Summary: Topological invariants play a central role in classifying quantum phases and describing various phenomena in matter. In this study, an unusual linking-number invariant associated with loops of electronic band crossings in a mirror-symmetric ferromagnet is observed. The experiment confirms the invariant structure and discovers related boundary states on the sample surface. This finding motivates further exploration of magnetic and superconducting quantum matter using knot theory.
Article
Plant Sciences
Hong-Yun Zeng, He-Nan Bao, Yi-Li Chen, Ding-Kang Chen, Kun Zhang, Shuai-Kang Liu, La Yang, Yong-Kang Li, Nan Yao
Summary: This study reveals that two classes of ceramide synthases differentially regulate EDS1/PAD4-dependent programmed cell death and immunity in Arabidopsis by subtly controlling long-chain bases and ceramides.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Heng Ni, Xiao Fan, Feng Zhou, Galio Guo, Jae Young Lee, Nadrian C. Seeman, Do-Nyun Kim, Nan Yao, Paul M. Chaikin, Yimo Han
Summary: This study visualized the aqueous structure of two-dimensional DNA origami and its assemblies, revealing the flexibility and assembly mechanisms in solution. The findings provide insights into the dynamic structures of two-dimensional DNA origami assemblies and their self-assembly and self-replication mechanisms.
Article
Engineering, Environmental
Xiaopei Wang, Xiuru Bi, Nan Yao, Gokhan Elmaci, Ali Serol Erturk, Qianru Lv, Peiqing Zhao, Xu Meng
Summary: In this study, a Cu-Nd-OMS-2 catalyst was synthesized and demonstrated to efficiently degrade water-soluble parabens by converting the radical mechanism into a non-radical pathway. The results showed that singlet oxygen and mediated electron transfer played important roles in the removal of pollutants.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell Biology
Tong Liu, Yali Fan, Qingsong Zhang, Yiming Wang, Nan Yao, Mengmeng Song, Qi Zhang, Liying Cao, Chunhua Song, Hanping Shi
Summary: The combination of metabolic syndrome and inflammation significantly increases the risk of colorectal cancer (CRC). Including CRP in the diagnosis of metabolic syndrome may help identify additional high-risk individuals for early diagnosis and prevention of CRC.
INFLAMMATION RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Danrui Ni, Kasey P. Devlin, Guangming Cheng, Xin Gui, Weiwei Xie, Nan Yao, Robert J. Cava
Summary: The synthesis of layered honeycomb polymorph of IrI3 at high pressure is reported. Faults in the honeycomb layer stacking are observed using different techniques. A previously unreported hyperhoneycomb polymorph of IrI3 is also discovered. IrI3 may be of future interest in the fabrication of new quantum materials.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qingquan Ma, Joshua Young, Sagnik Basuray, Guangming Cheng, Jianan Gao, Nan Yao, Wen Zhang
Summary: In this study, the facet-dependent electrochemical activities of Cu2O nanocrystals were investigated by synthesizing nanocrystals with different shapes and utilizing various characterization techniques. The results showed that rhombic dodecahedral Cu2O exhibited higher electrocatalytic activity, attributed to the dominant exposed {110} facet. Additionally, the surface work function and adsorptive properties of Cu2O were found to vary with the shape and dominant exposed facets. Density-functional theory calculations further confirmed the facet dependence of local surface energy and electronic structure of Cu2O nanocrystals.
Article
Chemistry, Physical
Nana Shumiya, Md Shafayat Hossain, Jia-Xin Yin, Zhiwei Wang, Maksim Litskevich, Chiho Yoon, Yongkai Li, Ying Yang, Yu-Xiao Jiang, Guangming Cheng, Yen-Chuan Lin, Qi Zhang, Zi-Jia Cheng, Tyler A. Cochran, Daniel Multer, Xian P. Yang, Brian Casas, Tay-Rong Chang, Titus Neupert, Zhujun Yuan, Shuang Jia, Hsin Lin, Nan Yao, Luis Balicas, Fan Zhang, Yugui Yao, M. Zahid Hasan
Summary: This study provides micro-spectroscopic evidence for the presence of a room-temperature quantum spin Hall edge state on the surface of a higher-order topological insulator. The research reveals the microstructural features of the topological phase and suggests further exploration of high-temperature transport quantization.
Article
Multidisciplinary Sciences
Xiaoming Zhao, Tianran Liu, Quinn C. Burlingame, Tianjun Liu, Rudolph Holley, Guangming Cheng, Nan Yao, Feng Gao, Yueh-Lin Loo
Summary: By incorporating a 2D capping layer, the stability of the interface in CsPbI3 PSCs can be improved, leading to an increased power conversion efficiency of all-inorganic PSCs. Accelerated aging tests can predict degradation rates and intrinsic lifetimes of PSCs at different temperatures.
Article
Chemistry, Multidisciplinary
Graciela Villalpando, Austin M. Ferrenti, Ratnadwip Singha, Xiaoyu Song, Guangming Cheng, Nan Yao, Leslie M. Schoop
Summary: In this study, a chemical exfoliation method was used to delaminate the layered antiferromagnet vanadium oxychloride, demonstrating the potential of chemical exfoliation and the effects of low dimensionality on magnetic properties.
Article
Engineering, Chemical
Nan Yao, Haiyu Zhao, Xiang Liu, Ali Serol Erturk, Gokhan Elmaci, Peiqing Zhao, Xu Meng
Summary: This study introduced the use of acidified rod-like manganese dioxide as an effective activator and adsorbent for the removal of polyvinyl alcohol. The results showed that the H-OMS-2 could efficiently adsorb and degrade PVA, and it had good recyclability. The presence of acid sites and highly structured mesoporous pore size on H-OMS-2 promoted the degradation of PVA.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Brianna L. Hoff, Guangming Cheng, Graciela Villalpando, Fang Yuan, Nan Yao, Leslie M. Schoop
Summary: Exploring 2D materials is crucial for the development of quantum materials. However, difficulties in their production have hindered progress. This study introduces a method for obtaining thin layers of beta-Bi2O3 using chemical exfoliation. The researchers successfully prepared beta-Bi2O3 nanosheets and suggested further exploration of their properties at the nanoscale and the potential use of chemical exfoliation for non-layered bulk materials.
JOURNAL OF PHYSICS-MATERIALS
(2022)