Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B

(2016) Jing Hu et al.   CANCER CELL

Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype

(2016) Ling Li et al.   CANCER RESEARCH

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling

(2016) Johnathon D. Anderson et al.   STEM CELLS

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

(2016) Xiujuan Li et al.   Nature Communications

VEGF pathway targeting agents, vessel normalization and tumor drug uptake: from bench to bedside

(2016) Marlous Arjaans et al.   Oncotarget

Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment

(2016) Elham Hosseini-Beheshti et al.   Oncotarget

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity

(2015) Evangelos Pefanis et al.   CELL

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

(2015) Olga Tornavaca et al.   JOURNAL OF CELL BIOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

CXCR7 mediates TGFβ1-promoted EMT and tumor-initiating features in lung cancer

(2015) Y-C Wu et al.   ONCOGENE

E2f3 in tumor macrophages promotes lung metastasis

(2015) P Trikha et al.   ONCOGENE

MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment

(2015) F J Kohlhapp et al.   ONCOGENE

Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis

(2015) Mélanie Tichet et al.   Nature Communications

Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche

(2015) Catherine A. Sánchez et al.   Oncotarget

Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p

(2015) Guoping Ding et al.   Oncotarget

Biphasic regulation of autophagy by miR-96 in prostate cancer cells under hypoxia

(2015) Yi Ma et al.   Oncotarget

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteosarcoma microenvironment

(2014) Shih-Wei Wang et al.   CARCINOGENESIS

The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer

(2014) John G Foster et al.   Future Oncology

Prognosis value of HIF-1α expression in patients with non-small cell lung cancer

(2014) Qian Wang et al.   GENE

Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing

(2014) Daisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes

(2014) H Cui et al.   ONCOGENE

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-induced miR-424 decreases tumor sensitivity to chemotherapy by inhibiting apoptosis

(2014) D Zhang et al.   Cell Death & Disease

Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

(2013) Dagmar Schumacher et al.   CANCER CELL

The proinflammatory peptide substance P promotes blood-brain barrier breaching by breast cancer cells through changes in microvascular endothelial cell tight junctions

(2013) Pedro L. Rodriguez et al.   INTERNATIONAL JOURNAL OF CANCER

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

(2012) Cristina Branco-Price et al.   CANCER CELL

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling

(2012) F. K. Pientka et al.   JOURNAL OF CELL SCIENCE

TGF- 1-Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

(2012) F. T. Borges et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Upregulation of Hypoxia-Inducible Factor-1α mRNA and its Clinical Significance in Non-small Cell Lung Cancer

(2010) Tomofumi Yohena et al.   Journal of Thoracic Oncology

MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

(2009) M. E. Crosby et al.   CANCER RESEARCH

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL