Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18

Caspase-11 deficiency impairs neutrophil recruitment and bacterial clearance in the early stage of pulmonary Klebsiella pneumoniae infection

(2017) Jian Wang et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Burkholderia pseudomallei Evades Nramp1 (Slc11a1)- and NADPH Oxidase-Mediated Killing in Macrophages and Exhibits Nramp1-Dependent Virulence Gene Expression

(2017) Veerachat Muangsombut et al.   Frontiers in Cellular and Infection Microbiology

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

(2016) Ine Jorgensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

(2016) Hanne Van Gorp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium

(2015) Youssef Aachoui et al.   Cell Host & Microbe

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA

(2015) Larissa D. Cunha et al.   Nature Communications

Control of Francisella tularensis Intracellular Growth by Pulmonary Epithelial Cells

(2015) Savannah Maggio et al.   PLoS One

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Neutrophil Elastase Causes Tissue Damage That Decreases Host Tolerance to Lung Infection with Burkholderia Species

(2014) Manoranjan Sahoo et al.   PLoS Pathogens

Revisiting Caspase-11 Function in Host Defense

(2013) Tessie M. Ng et al.   Cell Host & Microbe

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Inflammasome-dependent Pyroptosis and IL-18 Protect against Burkholderia pseudomallei Lung Infection while IL-1β Is Deleterious

(2011) Ivonne Ceballos-Olvera et al.   PLoS Pathogens

Toll-Like Receptor Signaling in Airborne Burkholderia thailandensis Infection

(2009) T. E. West et al.   INFECTION AND IMMUNITY

Caspase-1 Mediates Resistance in Murine Melioidosis

(2009) K. Breitbach et al.   INFECTION AND IMMUNITY

Inhalation of Burkholderia thailandensis results in lethal necrotizing pneumonia in mice: a surrogate model for pneumonic melioidosis

(2009) T. Eoin West et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Burkholderia thailandensis as a Model System for the Study of the Virulence-Associated Type III Secretion System of Burkholderia pseudomallei

(2008) A. Haraga et al.   INFECTION AND IMMUNITY

Francisella tularensis Invasion of Lung Epithelial Cells

(2008) R. R. Craven et al.   INFECTION AND IMMUNITY

MyD88 Dependent Signaling Contributes to Protective Host Defense against Burkholderia pseudomallei

(2008) W. Joost Wiersinga et al.   PLoS One