Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders

Alzheimer Disease: Non-pharmacological and pharmacological management of cognition and neuropsychiatric symptoms

(2018) Samantha M Loi et al.   Australasian Psychiatry

Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ 1 receptor

(2018) Tangui Maurice et al.   BEHAVIOURAL BRAIN RESEARCH

Separating Symptomatic Alzheimer’s Disease from Depression based on Structural MRI

(2018) Stefan Klöppel et al.   JOURNAL OF ALZHEIMERS DISEASE

Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC

(2018) Wayland W. L. Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GABAA receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus

(2018) Andrea Kwakowsky et al.   JOURNAL OF NEUROCHEMISTRY

Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning

(2018) Krista L. Wahlstrom et al.   JOURNAL OF NEUROSCIENCE

Transport of steroid 3-sulfates and steroid 17-sulfates by the sodium-dependent organic anion transporter SOAT (SLC10A6)

(2018) Gary Grosser et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Is Adjunctive Progesterone Effective in Reducing Seizure Frequency in Patients With Intractable Catamenial Epilepsy? A Critically Appraised Topic

(2018) Cristina Valencia-Sanchez et al.   NEUROLOGIST

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

(2018) Filippo Caraci et al.   PHARMACOLOGICAL RESEARCH

PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma

(2018) S.L. Pineles et al.   PSYCHONEUROENDOCRINOLOGY

Pyramidal cell-selective GluN1 knockout causes impairments in salience attribution and related EEG activity

(2018) Alexandra D. Forrest et al.   EXPERIMENTAL BRAIN RESEARCH

Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit

(2018) Vojtech Vyklicky et al.   Frontiers in Molecular Neuroscience

Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters

(2018) Markus Grube et al.   Frontiers in Pharmacology

Chronic Allopregnanolone Treatment Accelerates Alzheimer's Disease Development in AβPPSwePSEN1ΔE9 Mice

(2018) Sara K. Bengtsson et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multi-modal imaging investigation

(2018) Carl J. Hodgetts et al.   NEUROBIOLOGY OF AGING

17 beta-estradiol synthesis modulates cerebellar dependent motor memory formation in adult male rats

(2018) Cristina V. Dieni et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Spared and impaired sleep-dependent memory consolidation in schizophrenia

(2018) Bengi Baran et al.   SCHIZOPHRENIA RESEARCH

An Amygdala-Hippocampus Subnetwork that Encodes Variation in Human Mood

(2018) Lowry A. Kirkby et al.   CELL

Association between seizure freedom and default mode network reorganization in patients with unilateral temporal lobe epilepsy

(2018) Isabell Ofer et al.   EPILEPSY & BEHAVIOR

Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization

(2018) Mariangela Chisari et al.   NEUROPHARMACOLOGY

Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD

(2018) Ann M. Rasmusson et al.   PSYCHONEUROENDOCRINOLOGY

Allopregnanolone induces state-dependent fear via the bed nucleus of the stria terminalis

(2017) Gillian M. Acca et al.   HORMONES AND BEHAVIOR

Neonatal estradiol exposure to female rats changes GABA A receptor expression and function, and spatial learning during adulthood

(2017) Andrea Locci et al.   HORMONES AND BEHAVIOR

Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression

(2017) Stephen J. Kanes et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment

(2017) Susan M. Resnick et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Uptake and metabolism of sulphated steroids by the blood-brain barrier in the adult male rat

(2017) M. Zeeshan Qaiser et al.   JOURNAL OF NEUROCHEMISTRY

Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial

(2017) Stephen Kanes et al.   LANCET

TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

(2017) Anthony Bosson et al.   Molecular Neurodegeneration

Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antagonizing the GABA A receptor during behavioral training improves spatial memory at different doses in control and chronically stressed rats

(2017) Kenji J. Nishimura et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences

(2017) David H. Hackos et al.   NEUROPHARMACOLOGY

A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation

(2017) Borna Ghosh et al.   NEUROPHARMACOLOGY

Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model

(2017) Stephanie L. Ciarlone et al.   NEUROPHARMACOLOGY

α4βδ GABA A receptors reduce dendritic spine density in CA1 hippocampus and impair relearning ability of adolescent female mice: Effects of a GABA agonist and a stress steroid

(2017) Sonia Afroz et al.   NEUROSCIENCE

Neurosteroid dehydroepiandrosterone improves active avoidance retrieval and induces antidepressant-like behavior in rats

(2017) Janko Samardzic et al.   NEUROSCIENCE LETTERS

Developmental pruning of excitatory synaptic inputs to parvalbumin interneurons in monkey prefrontal cortex

(2017) Daniel W. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory impairment and the mediating role of task difficulty in patients with schizophrenia

(2017) Kyrsten M. Grimes et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

A randomized controlled trial of ganaxolone in posttraumatic stress disorder

(2017) Ann M. Rasmusson et al.   PSYCHOPHARMACOLOGY

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

(2017) Tal Nuriel et al.   Nature Communications

Structural basis for GABAA receptor potentiation by neurosteroids

(2017) Paul S Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain

(2017) Cui Yan Lu et al.   NEURAL PLASTICITY

GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies

(2017) Jeroen C. de Jonge et al.   Frontiers in Psychiatry

Estradiol is associated with altered cognitive and physiological responses during fear conditioning and extinction in healthy and spider phobic women.

(2016) Stella Li et al.   BEHAVIORAL NEUROSCIENCE

Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalization

(2016) Aarti Kuver et al.   BRAIN RESEARCH BULLETIN

TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis

(2016) Anna Santoro et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Does polycystic ovary syndrome affect cognition? A functional magnetic resonance imaging study exploring working memory

(2016) Remi S. Soleman et al.   FERTILITY AND STERILITY

Cognition in aged rhesus monkeys: effect of DHEA and correlation with steroidogenic gene expression

(2016) K. G. Sorwell et al.   GENES BRAIN AND BEHAVIOR

Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory

(2016) Vallent Lee et al.   HIPPOCAMPUS

Long-term continuous allopregnanolone elevation causes memory decline and hippocampus shrinkage, in female wild-type B6 mice

(2016) Sara K.S. Bengtsson et al.   HORMONES AND BEHAVIOR

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

(2016) P. Porcu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Dopamine transporter mutant animals: a translational perspective

(2016) Evgeniya V. Efimova et al.   JOURNAL OF NEUROGENETICS

Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains

(2016) T. J. Wilding et al.   JOURNAL OF NEUROSCIENCE

Age and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole

(2016) A C Pereira et al.   MOLECULAR PSYCHIATRY

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Promnestic effects of intranasally applied pregnenolone in rats

(2016) Laila Abdel-Hafiz et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Agonist and antagonist bind differently to 5-HT 1A receptors during Alzheimer’s disease: A post-mortem study with PET radiopharmaceuticals

(2016) Benjamin Vidal et al.   NEUROPHARMACOLOGY

A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition

(2016) Xiaoping Jiang et al.   NEUROPHARMACOLOGY

Changes in stress-stimulated allopregnanolone levels induced by neonatal estradiol treatment are associated with enhanced dopamine release in adult female rats: reversal by progesterone administration

(2016) Patrizia Porcu et al.   PSYCHOPHARMACOLOGY

Clinical Potential of Neurosteroids for CNS Disorders

(2016) Doodipala Samba Reddy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Assessing rodent hippocampal involvement in the novel object recognition task. A review

(2015) Sarah J. Cohen et al.   BEHAVIOURAL BRAIN RESEARCH

Neurosteroid effects at α4βδ GABA A receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse

(2015) Nicole Sabaliauskas et al.   BRAIN RESEARCH

Women with polycystic ovary syndrome have elevated serum concentrations of and altered GABAAreceptor sensitivity to allopregnanolone

(2015) Helena Hedström et al.   CLINICAL ENDOCRINOLOGY

The Regulation of Steroid Action by Sulfation and Desulfation

(2015) Jonathan W. Mueller et al.   ENDOCRINE REVIEWS

Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats

(2015) Adam J. Devall et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Effects of the Synthetic Neurosteroid

(2015) Lucie Parésys et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Individual Differences in Biophysiological Toughness: Sustaining Working Memory During Physical Exhaustion

(2015) Regina M. Shia et al.   MILITARY MEDICINE

Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials

(2015) Y Iwata et al.   MOLECULAR PSYCHIATRY

The paraventricular thalamus controls a central amygdala fear circuit

(2015) Mario A. Penzo et al.   NATURE

Altered expression of δGABAA receptors in health and disease

(2015) Paul D. Whissell et al.   NEUROPHARMACOLOGY

Allopregnanolone enhances the neurogenesis of midbrain dopaminergic neurons in APPswe/PSEN1 mice

(2015) P. Zhang et al.   NEUROSCIENCE

Allopregnanolone increases mature excitatory synapses along dendrites via protein kinase A signaling

(2015) H. Shimizu et al.   NEUROSCIENCE

Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats

(2015) Naomi Nagaya et al.   Frontiers in Behavioral Neuroscience

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway

(2015) P Wong et al.   Translational Psychiatry

Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease

(2015) Ronald W. Irwin et al.   PLoS One

Testosterone Treatment of Men With Mild Cognitive Impairment and Low Testosterone Levels

(2014) M. M. Cherrier et al.   American Journal of Alzheimers Disease and Other Dementias

The role of sex and sex-related hormones in cognition, mood and well-being in older men and women

(2014) Teresa Costa Castanho et al.   BIOLOGICAL PSYCHOLOGY

The neurosteroid allopregnanolone impairs object memory and contextual fear memory in male C57BL/6J mice

(2014) Akiva Rabinowitz et al.   HORMONES AND BEHAVIOR

Allopregnanolone levels and seizure frequency in progesterone-treated women with epilepsy

(2014) A. G. Herzog et al.   NEUROLOGY

Different oxysterols have opposing actions at N-methyl-d-aspartate receptors

(2014) Andrew J. Linsenbardt et al.   NEUROPHARMACOLOGY

A Randomized, Double-Blind, Placebo-Controlled Trial of Pregnenolone for Bipolar Depression

(2014) E Sherwood Brown et al.   NEUROPSYCHOPHARMACOLOGY

Parvalbumin Cell Ablation of NMDA-R1 Causes Increased Resting Network Excitability with Associated Social and Self-Care Deficits

(2014) Eddie N Billingslea et al.   NEUROPSYCHOPHARMACOLOGY

Replication of SULT4A1-1 as a pharmacogenetic marker of olanzapine response and evidence of lower weight gain in the high response group

(2014) Timothy L Ramsey et al.   PHARMACOGENOMICS

Pregnenolone sulfate infused in lateral septum of male rats impairs novel object recognition memory

(2014) Federico Nanfaro et al.   Pharmacological Reports

The Relationship between Dehydroepiandrosterone (DHEA), Working Memory and Distraction – A Behavioral and Electrophysiological Approach

(2014) Sónia do Vale et al.   PLoS One

Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: An 8-week, double-blind, randomized add-on two-center trial

(2014) Michael S. Ritsner et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Relation of progesterone and DHEAS serum levels to 5-HT1A receptor binding potential in pre- and postmenopausal women

(2014) Patrycja Stein et al.   PSYCHONEUROENDOCRINOLOGY

Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia

(2014) Christine E. Marx et al.   PSYCHOPHARMACOLOGY

Pregnenolone sulfate as a modulator of synaptic plasticity

(2014) Conor C. Smith et al.   PSYCHOPHARMACOLOGY

Pregnenolone Can Protect the Brain from Cannabis Intoxication

(2014) Monique Vallée et al.   SCIENCE

Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder

(2014) Graziano Pinna et al.   Frontiers in Cellular Neuroscience

Pregnenolone Sulfate Restores the Glutamate-Nitric-Oxide-cGMP Pathway and Extracellular GABA in Cerebellum and Learning and Motor Coordination in Hyperammonemic Rats

(2013) Alba Gonzalez-Usano et al.   ACS Chemical Neuroscience

Pregnenolone sulphate enhances spatial orientation and object discrimination in adult male rats: Evidence from a behavioural and electrophysiological study

(2013) Fulvio Plescia et al.   BEHAVIOURAL BRAIN RESEARCH

The role of pregnenolone sulphate in spatial orientation-acquisition and retention: An interplay between cognitive potentiation and mood regulation

(2013) Fulvio Plescia et al.   BEHAVIOURAL PROCESSES

Allopregnanolone Elevations Following Pregnenolone Administration Are Associated with Enhanced Activation of Emotion Regulation Neurocircuits

(2013) Rebecca K. Sripada et al.   BIOLOGICAL PSYCHIATRY

The development of benzo- and naphtho-fused quinoline-2,4-dicarboxylic acids as vesicular glutamate transporter (VGLUT) inhibitors reveals a possible role for neuroactive steroids

(2013) Christina N. Carrigan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

Brief but Chronic Increase in Allopregnanolone Cause Accelerated AD Pathology Differently in Two Mouse Models

(2013) Sara K. Bengtsson et al.   Current Alzheimer Research

GLUCOCORTICOIDS ENHANCE IN VIVO EXPOSURE-BASED THERAPY OF SPIDER PHOBIA

(2013) Leila M. Soravia et al.   DEPRESSION AND ANXIETY

COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS

(2013) Roger S. McIntyre et al.   DEPRESSION AND ANXIETY

The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity

(2013) Rebecca K. Sripada et al.   HUMAN BRAIN MAPPING

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand

(2013) Christian Harteneck   MOLECULES

Neurosteroids as regenerative agents in the brain: therapeutic implications

(2013) Roberta D. Brinton   Nature Reviews Endocrinology

Neurosteroid Agonist at GABAA Receptor Induces Persistent Neuroplasticity in VTA Dopamine Neurons

(2013) Elena Vashchinkina et al.   NEUROPSYCHOPHARMACOLOGY

DHEA Enhances Emotion Regulation Neurocircuits and Modulates Memory for Emotional Stimuli

(2013) Rebecca K Sripada et al.   NEUROPSYCHOPHARMACOLOGY

Neonatal allopregnanolone levels alteration: Effects on behavior and role of the hippocampus

(2013) S. Darbra et al.   PROGRESS IN NEUROBIOLOGY

Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABAA receptors on parvalbumin interneurons

(2013) Isabella Ferando et al.   Frontiers in Neural Circuits

Women with acute intermittent porphyria have a defect in 5α-steroid production during the menstrual cycle

(2012) EVA INNALA et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Alteration of neonatal Allopregnanolone levels affects exploration, anxiety, aversive learning and adult behavioural response to intrahippocampal neurosteroids

(2012) Laura Mòdol et al.   BEHAVIOURAL BRAIN RESEARCH

Administration of dehydroepiandrosterone (DHEA) increases serum levels of androgens and estrogens but does not enhance short-term memory in post-menopausal women

(2012) Paul Merritt et al.   BRAIN RESEARCH

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model

(2012) J. D. Murray et al.   CEREBRAL CORTEX

Distribution and Posttranslational Modification of Synaptic ERα in the Adult Female Rat Hippocampus

(2012) Nino Tabatadze et al.   ENDOCRINOLOGY

Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit

(2012) Chessa S. Scullin et al.   HIPPOCAMPUS

Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder

(2012) Rebecca Sripada et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

The episodic nature of episodic-like memories

(2012) A. Easton et al.   LEARNING & MEMORY

Age-related changes in neuroactive steroid levels in 3xTg-AD mice

(2012) Donatella Caruso et al.   NEUROBIOLOGY OF AGING

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

The NMDA receptor as a target for cognitive enhancement

(2012) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress

(2012) A.L. Lussier et al.   NEUROSCIENCE

Neural Dysregulation in Posttraumatic Stress Disorder

(2012) Rebecca K. Sripada et al.   PSYCHOSOMATIC MEDICINE

The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia

(2012) Diana C. Rotaru et al.   REVIEWS IN THE NEUROSCIENCES

NMDA Receptor Hypofunction, Parvalbumin-Positive Neurons, and Cortical Gamma Oscillations in Schizophrenia

(2012) G. Gonzalez-Burgos et al.   SCHIZOPHRENIA BULLETIN

Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors

(2012) Krasnodara Cameron et al.   STEROIDS

The influence of emergency contraception on post-traumatic stress symptoms following sexual assault

(2012) Nikole K. Ferree et al.   Journal of Forensic Nursing

Neuroregenerative Mechanisms of Allopregnanolone in Alzheimer’s Disease

(2012) Ronald W. Irwin et al.   Frontiers in Endocrinology

Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning

(2011) Laura Mòdol et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction

(2011) Darrick T. Balu et al.   BRAIN RESEARCH

Sources of inputs to the anterior and posterior aspects of the paraventricular nucleus of the thalamus

(2011) Sa Li et al.   Brain Structure & Function

Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice

(2011) M. Miyajima et al.   DRUG METABOLISM AND DISPOSITION

Increased serum levels of dehydroepiandrosterone (DHEA) and interleukin-6 (IL-6) in women with mild to moderate Alzheimer's disease

(2011) Sigbritt Rasmuson et al.   INTERNATIONAL PSYCHOGERIATRICS

Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats

(2011) Paula A. Zamudio-Bulcock et al.   JOURNAL OF NEUROCHEMISTRY

A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons

(2011) Emmanuel Kostakis et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of 5α-Reductase Activity in Late Pregnancy Decreases Gestational Length and Fecundity and Impairs Object Memory and Central Progestogen Milieu of Juvenile Rat Offspring

(2011) J. J. Paris et al.   JOURNAL OF NEUROENDOCRINOLOGY

Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen

(2011) Yuuki Ooishi et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lifetime Prevalence of Mental Disorders in U.S. Adolescents: Results from the National Comorbidity Survey Replication–Adolescent Supplement (NCS-A)

(2011) Kathleen Ries Merikangas et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Progesterone at encoding predicts subsequent emotional memory

(2011) N. Ertman et al.   LEARNING & MEMORY

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior

(2011) M Carlén et al.   MOLECULAR PSYCHIATRY

Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors

(2011) Graham M Pitcher et al.   NATURE MEDICINE

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

(2011) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

Interneuron loss reduces dendritic inhibition and GABA release in hippocampus of aged rats

(2011) Emily M. Stanley et al.   NEUROBIOLOGY OF AGING

Perimenopausal regulation of steroidogenesis in the nonhuman primate

(2011) Krystina G. Sorwell et al.   NEUROBIOLOGY OF AGING

Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice

(2011) Chanpreet Singh et al.   NEUROBIOLOGY OF AGING

Hormonal contraception usage is associated with altered memory for an emotional story

(2011) Shawn E. Nielsen et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Progesterone Level Predicts Serotonin-1A Receptor Binding in the Male Human Brain

(2011) Rupert Lanzenberger et al.   NEUROENDOCRINOLOGY

Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence

(2011) C.E. Marx et al.   NEUROSCIENCE

Effects of pregnanolone and flunitrazepam on the retention of response sequences in rats

(2011) Russell J. Amato et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Allopregnanolone Promotes Regeneration and Reduces β-Amyloid Burden in a Preclinical Model of Alzheimer's Disease

(2011) Shuhua Chen et al.   PLoS One

Age-related memory deficits linked to circuit-specific disruptions in the hippocampus

(2011) M. A. Yassa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects

(2011) Miloslav Korinek et al.   STEROIDS

Large-scale brain networks and psychopathology: a unifying triple network model

(2011) Vinod Menon   TRENDS IN COGNITIVE SCIENCES

Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis

(2011) Iakovos Lazaridis et al.   PLOS BIOLOGY

Neuroprotective Actions of Neurosteroids

(2011) Kinga K. Borowicz et al.   Frontiers in Endocrinology

Elevated Cortisol in Older Adults With Generalized Anxiety Disorder Is Reduced by Treatment: A Placebo-Controlled Evaluation of Escitalopram

(2010) Eric J. Lenze et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects

(2010) Jennifer C. Naylor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Low Brain Allopregnanolone Levels Mediate Flattened Circadian Activity Associated with Memory Impairments in Aged Rats

(2010) Olivier George et al.   BIOLOGICAL PSYCHIATRY

Kinetic and Structural Determinants for GABA-A Receptor Potentiation by Neuroactive Steroids

(2010) Gustav Akk et al.   Current Neuropharmacology

Pregnenolone and Dehydroepiandrosterone as an Adjunctive Treatment in Schizophrenia and Schizoaffective Disorder

(2010) Michael S. Ritsner et al.   JOURNAL OF CLINICAL PSYCHIATRY

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

(2010) Pietro Fazzari et al.   NATURE

Circulating Levels of Allopregnanolone, a Neuroactive Steroid, and Leptin during Treatment with Valproic Acid in Children with Epilepsy

(2010) Salvatore Grosso et al.   NEUROENDOCRINOLOGY

S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice

(2010) Marianela Nelson et al.   NEUROPHARMACOLOGY

Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear

(2010) Demetrio Sierra-Mercado et al.   NEUROPSYCHOPHARMACOLOGY

Pregnenolone sulfate enhances spontaneous glutamate release by inducing presynaptic Ca2+-induced Ca2+ release

(2010) K.H. Lee et al.   NEUROSCIENCE

Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapses

(2010) P.A. Zamudio-Bulcock et al.   NEUROSCIENCE

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

(2010) J. M. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant salience network (bilateral insula and anterior cingulate cortex) connectivity during information processing in schizophrenia

(2010) Thomas P. White et al.   SCHIZOPHRENIA RESEARCH

A Critical Role for  4   GABAA Receptors in Shaping Learning Deficits at Puberty in Mice

(2010) H. Shen et al.   SCIENCE

Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer's disease (AD) patients

(2009) Sarah Aldred et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Modulation of synaptic plasticity by brain estrogen in the hippocampus

(2009) Hideo Mukai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Modulatory metaplasticity induced by pregnenolone sulfate in the rat hippocampus: A leftward shift in LTP/LTD-frequency curve

(2009) Ling Chen et al.   HIPPOCAMPUS

Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABAA receptor modulators in adulthood

(2009) Sònia Darbra et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

The developmental course of anxiety symptoms during adolescence: the TRAILS study

(2009) F.V.A. Van Oort et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

What is remembered? Role of attention on the encoding and retrieval of hippocampal representations

(2009) Isabel A. Muzzio et al.   JOURNAL OF PHYSIOLOGY-LONDON

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning

(2009) Peer Wulff et al.   NATURE NEUROSCIENCE

Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease

(2009) Emily R. Rosario et al.   NEUROBIOLOGY OF AGING

Treatment Strategies Targeting Excess Hippocampal Activity Benefit Aged Rats with Cognitive Impairment

(2009) Ming Teng Koh et al.   NEUROPSYCHOPHARMACOLOGY

Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia

(2009) Christine E Marx et al.   NEUROPSYCHOPHARMACOLOGY

Pregnenolone sulfate modulation of N-methyl-d-aspartate receptors is phosphorylation dependent

(2009) M. Petrovic et al.   NEUROSCIENCE

Dehydroepiandrosterone and neurotrophins favor axonal growth in a sensory neuron–keratinocyte coculture model

(2009) L. Ulmann et al.   NEUROSCIENCE

Prevalence and Treatment of Mental Disorders Among US Children in the 2001-2004 NHANES

(2009) K. R. Merikangas et al.   PEDIATRICS

Estradiol and the relationship between dendritic spines, NR2B containing NMDA receptors, and the magnitude of long-term potentiation at hippocampal CA3–CA1 synapses

(2009) Caroline C. Smith et al.   PSYCHONEUROENDOCRINOLOGY

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

(2008) Nicole Maninger et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Steroidogenic Activity of StAR Requires Contact with Mitochondrial VDAC1 and Phosphate Carrier Protein

(2008) Mahuya Bose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The functional anatomy of semantic retrieval is influenced by gender, menstrual cycle, and sex hormones

(2008) C. Konrad et al.   JOURNAL OF NEURAL TRANSMISSION

Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum

(2008) Matthew T. Whittaker et al.   JOURNAL OF NEUROCHEMISTRY

Membrane Estrogen Receptors Acting Through Metabotropic Glutamate Receptors: An Emerging Mechanism of Estrogen Action in Brain

(2008) Paul E. Micevych et al.   MOLECULAR NEUROBIOLOGY

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

(2008) Thomas F.J. Wagner et al.   NATURE CELL BIOLOGY

Conserved site for neurosteroid modulation of GABAA receptors

(2008) Alastair M. Hosie et al.   NEUROPHARMACOLOGY

Stressful experience has opposite effects on dendritic spines in the hippocampus of cycling versus masculinized females

(2008) Christina Dalla et al.   NEUROSCIENCE LETTERS

Etifoxine improves peripheral nerve regeneration and functional recovery

(2008) C. Girard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels

(2008) K. Nagatomo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder

(2008) Rose C. Mantella et al.   PSYCHONEUROENDOCRINOLOGY

Allopregnanolone impairs episodic memory in healthy women

(2008) Kristiina Kask et al.   PSYCHOPHARMACOLOGY

Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia

(2008) John E. Lisman et al.   TRENDS IN NEUROSCIENCES

Modulation of glutamatergic transmission by sulfated steroids: Role in fetal alcohol spectrum disorder

(2007) C. Fernando Valenzuela et al.   BRAIN RESEARCH REVIEWS

Pregnenolone sulfate in the brain: A controversial neurosteroid

(2007) Michael Schumacher et al.   NEUROCHEMISTRY INTERNATIONAL

Convergence of unimodal and polymodal sensory input to the entorhinal cortex in the fascicularis monkey

(2007) A. Mohedano-Moriano et al.   NEUROSCIENCE