Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research
Authors
Keywords
-
Journal
JOURNAL OF NEUROENDOCRINOLOGY
Volume 28, Issue 2, Pages n/a-n/a
Publisher
Wiley
Online
2015-12-18
DOI
10.1111/jne.12351
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Identification of a Key Cholesterol Binding Enhancement Motif in Translocator Protein 18 kDa
- (2015) Fei Li et al. BIOCHEMISTRY
- GABAA receptor-acting neurosteroids: A role in the development and regulation of the stress response
- (2015) Benjamin G. Gunn et al. FRONTIERS IN NEUROENDOCRINOLOGY
- Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma
- (2015) Donatella Caruso et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- New steps forward in the neuroactive steroid field
- (2015) Silvia Giatti et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Anti-tumor effects of progesterone in human glioblastoma multiforme: Role of PI3K/Akt/mTOR signaling
- (2015) Fahim Atif et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Progesterone and allopregnanolone in the central nervous system: Response to injury and implication for neuroprotection
- (2015) R. Guennoun et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Dihydrotestosterone as a Protective Agent in Chronic Experimental Autoimmune Encephalomyelitis
- (2015) Silvia Giatti et al. NEUROENDOCRINOLOGY
- Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation
- (2015) Jinjiang Fan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female mice
- (2015) Ana Belen Lopez-Rodriguez et al. PSYCHONEUROENDOCRINOLOGY
- Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism
- (2015) F. Li et al. SCIENCE
- Neuroactive steroids and the peripheral nervous system: An update
- (2015) Silvia Giatti et al. STEROIDS
- Lost in translocation: the functions of the 18-kD translocator protein
- (2015) Philipp Gut et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Local modulation of steroid action: rapid control of enzymatic activity
- (2015) Thierry D. Charlier et al. Frontiers in Neuroscience
- Failure of Acute Ethanol Administration to Alter Cerebrocortical and Hippocampal Allopregnanolone Levels in C57BL/6J and DBA/2J Mice
- (2014) Patrizia Porcu et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Chronic Intermittent Ethanol Exposure and Withdrawal Alters (3α,5α)-3-Hydroxy-Pregnan-20-One Immunostaining in Cortical and Limbic Brain Regions of C57BL/6J Mice
- (2014) Antoniette M. Maldonado-Devincci et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Pediatric super-refractory status epilepticus treated with allopregnanolone
- (2014) Eileen Broomall et al. ANNALS OF NEUROLOGY
- Improvement of neuronal bioenergetics by neurosteroids: Implications for age-related neurodegenerative disorders
- (2014) Amandine Grimm et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Peripheral Benzodiazepine Receptor/Translocator Protein Global Knock-out Mice Are Viable with No Effects on Steroid Hormone Biosynthesis
- (2014) Lan N. Tu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroactive steroid levels in plasma and cerebrospinal fluid of male multiple sclerosis patients
- (2014) Donatella Caruso et al. JOURNAL OF NEUROCHEMISTRY
- Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging
- (2014) Eduardo Zimmer et al. Journal of Neuroinflammation
- Overexpression of the Steroidogenic Enzyme Cytochrome P450 Side Chain Cleavage in the Ventral Tegmental Area Increases 3 ,5 -THP and Reduces Long-Term Operant Ethanol Self-Administration
- (2014) J. B. Cook et al. JOURNAL OF NEUROSCIENCE
- Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders
- (2014) Song-Yu Yang et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Allopregnanolone levels and seizure frequency in progesterone-treated women with epilepsy
- (2014) A. G. Herzog et al. NEUROLOGY
- Ethanol Alters Local Cellular Levels of (3α,5α)-3-Hydroxypregnan-20-one (3α,5α-THP) Independent of the Adrenals in Subcortical Brain Regions
- (2014) Jason B Cook et al. NEUROPSYCHOPHARMACOLOGY
- Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors
- (2014) A. M. Abramian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J Mice
- (2014) Eric W. Fish et al. PSYCHOPHARMACOLOGY
- Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies
- (2014) Patrizia Porcu et al. PSYCHOPHARMACOLOGY
- Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3α,5α-THP-facilitated lordosis of female rats
- (2014) C. A. Frye et al. PSYCHOPHARMACOLOGY
- Dutasteride reduces alcohol’s sedative effects in men in a human laboratory setting and reduces drinking in the natural environment
- (2014) Jonathan Covault et al. PSYCHOPHARMACOLOGY
- Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats
- (2014) C. A. Frye et al. PSYCHOPHARMACOLOGY
- Pregnenolone sulfate as a modulator of synaptic plasticity
- (2014) Conor C. Smith et al. PSYCHOPHARMACOLOGY
- Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand
- (2014) ukasz Jaremko et al. SCIENCE
- Pregnenolone Can Protect the Brain from Cannabis Intoxication
- (2014) Monique Vallée et al. SCIENCE
- Novel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptor
- (2014) Cheryl A. Frye et al. Frontiers in Cellular Neuroscience
- Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders
- (2014) Ronald W. Irwin et al. Frontiers in Cellular Neuroscience
- Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder
- (2014) Graziano Pinna et al. Frontiers in Cellular Neuroscience
- Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
- (2014) Richard B. Banati et al. Nature Communications
- Targeting neurosteroidogenesis as therapy for PTSD
- (2014) Graziano Pinna Frontiers in Pharmacology
- Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report
- (2013) Michael S. Irwig ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Ethanol Administration Produces Divergent Changes in GABAergic Neuroactive Steroid Immunohistochemistry in the Rat Brain
- (2013) Jason B. Cook et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- On the Role of the Translocator Protein (18-kDa) TSPO in Steroid Hormone Biosynthesis
- (2013) Vassilios Papadopoulos ENDOCRINOLOGY
- Translocator Protein/Peripheral Benzodiazepine Receptor Is Not Required for Steroid Hormone Biosynthesis
- (2013) Kanako Morohaku et al. ENDOCRINOLOGY
- Neuroactive steroids for the treatment of status epilepticus
- (2013) Michael A. Rogawski et al. EPILEPSIA
- Neonatal exposure to estradiol decreases hypothalamic allopregnanolone concentrations and alters agonistic and sexual but not affective behavior in adult female rats
- (2013) R. Berretti et al. HORMONES AND BEHAVIOR
- Neonatal finasteride administration alters hippocampal α4 and δ GABAAR subunits expression and behavioural responses to progesterone in adult rats
- (2013) Laura Modol et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Pregnane Xenobiotic Receptors and Membrane Progestin Receptors: Role in Neurosteroid-Mediated Motivated Behaviours
- (2013) C. A. Frye et al. JOURNAL OF NEUROENDOCRINOLOGY
- Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease
- (2013) A. M. Barron et al. JOURNAL OF NEUROSCIENCE
- Motivated Behaviors and Levels of 3α,5α-THP in the Midbrain Are Attenuated by Knocking Down Expression of Pregnane Xenobiotic Receptor in the Midbrain Ventral Tegmental Area of Proestrous Rats
- (2013) Cheryl Anne Frye et al. Journal of Sexual Medicine
- Steroid hormone synthesis in mitochondria
- (2013) Walter L. Miller MOLECULAR AND CELLULAR ENDOCRINOLOGY
- LXR Agonists: New Potential Therapeutic Drug for Neurodegenerative Diseases
- (2013) Pei Xu et al. MOLECULAR NEUROBIOLOGY
- Neurosteroids as regenerative agents in the brain: therapeutic implications
- (2013) Roberta D. Brinton Nature Reviews Endocrinology
- Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5α-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex
- (2013) Cheryl A. Frye et al. NEUROSCIENCE LETTERS
- Allopregnanolone: State of the art
- (2013) Roberto Cosimo Melcangi et al. PROGRESS IN NEUROBIOLOGY
- Allopregnanolone as regenerative therapeutic for Alzheimer's disease: Translational development and clinical promise
- (2013) Ronald W. Irwin et al. PROGRESS IN NEUROBIOLOGY
- Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions
- (2013) Roberto Cosimo Melcangi et al. PROGRESS IN NEUROBIOLOGY
- The role of allopregnanolone in depression and anxiety
- (2013) Cornelius Schüle et al. PROGRESS IN NEUROBIOLOGY
- Allopregnanolone and mood disorders
- (2013) T. Bäckström et al. PROGRESS IN NEUROBIOLOGY
- Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability
- (2013) Chase Matthew Carver et al. PSYCHOPHARMACOLOGY
- Translocator protein (Tspo) gene promoter-driven green fluorescent protein synthesis in transgenic mice: an in vivo model to study Tspo transcription
- (2012) Hui-Jie Wang et al. CELL AND TISSUE RESEARCH
- Progesterone Receptors: A Key for Neuroprotection in Experimental Stroke
- (2012) Ailing Liu et al. ENDOCRINOLOGY
- A 5-methylcytosine hotspot responsible for the prevalent HSD17B10 mutation
- (2012) Song-Yu Yang et al. GENE
- Neuroactive steroids, their metabolites, and neuroinflammation
- (2012) Silvia Giatti et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Neuroprotective Effects of Progesterone in Chronic Experimental Autoimmune Encephalomyelitis
- (2012) S. Giatti et al. JOURNAL OF NEUROENDOCRINOLOGY
- Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease
- (2012) S. Mandrekar-Colucci et al. JOURNAL OF NEUROSCIENCE
- Age-related changes in neuroactive steroid levels in 3xTg-AD mice
- (2012) Donatella Caruso et al. NEUROBIOLOGY OF AGING
- LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals
- (2012) Nico Mitro et al. NEUROCHEMISTRY INTERNATIONAL
- Long-term administration with levonorgestrel decreases allopregnanolone levels and alters GABAA receptor subunit expression and anxiety-like behavior
- (2012) Patrizia Porcu et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease
- (2012) Samuel O. Adeosun et al. PLoS One
- Variation in Genes Encoding the Neuroactive Steroid Synthetic Enzymes 5α-Reductase Type 1 and 3α-Reductase Type 2 Is Associated With Alcohol Dependence
- (2011) Verica Milivojevic et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Impaired neurosteroid synthesis in multiple sclerosis
- (2011) Farshid Noorbakhsh et al. BRAIN
- Progesterone attenuates astro- and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury
- (2011) Florencia Labombarda et al. EXPERIMENTAL NEUROLOGY
- Translocator Protein (18 kDa) as a Target for Novel Anxiolytics with a Favourable Side-Effect Profile
- (2011) C. Nothdurfter et al. JOURNAL OF NEUROENDOCRINOLOGY
- Novel Substrates for, and Sources of, Progestogens for Reproduction
- (2011) Cheryl Anne Frye JOURNAL OF NEUROENDOCRINOLOGY
- Milestones on Steroids and the Nervous System: 10 Years of Basic and Translational Research
- (2011) G. C. Panzica et al. JOURNAL OF NEUROENDOCRINOLOGY
- Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation
- (2011) K. Tokuda et al. JOURNAL OF NEUROSCIENCE
- Hydroxysteroid (17β) dehydrogenase X in human health and disease
- (2011) Song-Yu Yang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- A Novel Mutation in the HSD17B10 Gene of a 10-Year-Old Boy with Refractory Epilepsy, Choreoathetosis and Learning Disability
- (2011) Laurie H. Seaver et al. PLoS One
- A history of depression in women is associated with an altered GABAergic neuroactive steroid profile
- (2011) Susan S. Girdler et al. PSYCHONEUROENDOCRINOLOGY
- Pregnenolone and Ganaxolone Reduce Operant Ethanol Self-Administration in Alcohol-Preferring P Rats
- (2010) Joyce Besheer et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- II. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus
- (2010) Jason J. Paris et al. BRAIN RESEARCH
- 3β-HSD in songbird brain: subcellular localization and rapid regulation by estradiol
- (2010) Devaleena S. Pradhan et al. JOURNAL OF NEUROCHEMISTRY
- Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis
- (2010) Donatella Caruso et al. JOURNAL OF NEUROCHEMISTRY
- Activation of the Liver X Receptor Increases Neuroactive Steroid Levels and Protects from Diabetes-Induced Peripheral Neuropathy
- (2010) G. Cermenati et al. JOURNAL OF NEUROSCIENCE
- Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
- (2010) Rainer Rupprecht et al. NATURE REVIEWS DRUG DISCOVERY
- The role of progestins in the behavioral effects of cocaine and other drugs of abuse: Human and animal research
- (2010) Justin J. Anker et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Progesterone enhances learning and memory of aged wildtype and progestin receptor knockout mice
- (2010) Cheryl A. Frye et al. NEUROSCIENCE LETTERS
- Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease
- (2010) J. M. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential effects of allopregnanolone on the escalation of cocaine self-administration and sucrose intake in female rats
- (2010) Justin J. Anker et al. PSYCHOPHARMACOLOGY
- Progesterone reduces depression-like behavior in a murine model of Alzheimer’s Disease
- (2009) Cheryl A. Frye et al. AGE
- Differential Effects of Ethanol on Serum GABAergic 3α,5α/3α,5β Neuroactive Steroids in Mice, Rats, Cynomolgus Monkeys, and Humans
- (2009) Patrizia Porcu et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Estrogen receptor alpha interacts with 17β-hydroxysteroid dehydrogenase type 10 in mitochondria
- (2009) Virginija Jazbutyte et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
- (2009) F. Dutheil et al. DRUG METABOLISM AND DISPOSITION
- The Spontaneous Ala147Thr Amino Acid Substitution within the Translocator Protein Influences Pregnenolone Production in Lymphomonocytes of Healthy Individuals
- (2009) Barbara Costa et al. ENDOCRINOLOGY
- Translocator protein (18 kDa) TSPO: An emerging therapeutic target in neurotrauma
- (2009) Vassilios Papadopoulos et al. EXPERIMENTAL NEUROLOGY
- Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats
- (2009) Marzia Pesaresi et al. HORMONES AND BEHAVIOR
- Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release andde novoadrenal StAR synthesis
- (2009) Kevin N. Boyd et al. JOURNAL OF NEUROCHEMISTRY
- Changes in Expression and Function of Extrasynaptic GABAA Receptors in the Rat Hippocampus during Pregnancy and after Delivery
- (2009) E. Sanna et al. JOURNAL OF NEUROSCIENCE
- Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia
- (2009) Christine E Marx et al. NEUROPSYCHOPHARMACOLOGY
- Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism
- (2009) S.-Y. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lack of tolerance to anxiolysis and withdrawal symptoms in mice repeatedly treated with AC-5216, a selective TSPO ligand
- (2009) Atsuko Kita et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects
- (2009) Rainer Rupprecht et al. SCIENCE
- Nuclear Receptors and Inflammatory Diseases
- (2008) Kun Wang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Treatment with LXR agonists after focal cerebral ischemia prevents brain damage
- (2008) Luigi Sironi et al. FEBS LETTERS
- Neuroactive Steroid Stereospecificity of Ethanol-Like Discriminative Stimulus Effects in Monkeys
- (2008) K. A. Grant et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- GABAAR Plasticity during Pregnancy: Relevance to Postpartum Depression
- (2008) Jamie Maguire et al. NEURON
- Estradiol and the Developing Brain
- (2008) MARGARET M. McCARTHY PHYSIOLOGICAL REVIEWS
- Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder
- (2008) F. Pibiri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Allopregnanolone impairs episodic memory in healthy women
- (2008) Kristiina Kask et al. PSYCHOPHARMACOLOGY
- Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice
- (2008) Deborah A. Finn et al. PSYCHOPHARMACOLOGY
- Effects of progesterone administration and APPswe+PSEN1Δe9 mutation for cognitive performance of mid-aged mice
- (2007) Cheryl A. Frye et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Differential hypothalamic–pituitary–adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects
- (2007) Patrizia Porcu et al. PSYCHONEUROENDOCRINOLOGY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started