Article
Geriatrics & Gerontology
Intira Sriprasert, Melissa Mert, Wendy J. Mack, Howard N. Hodis, Donna Shoupe
Summary: The study showed that oral estradiol plus vaginal progesterone leads to increased endometrial thickness and a higher risk of endometrial hyperplasia, suggesting the need for further investigation into alternative doses or frequencies of administration for adequate endometrial protection from estrogen therapy in postmenopausal women.
Review
Chemistry, Medicinal
Justine Tang, Li-Ru Chen, Kuo-Hu Chen
Summary: Dehydroepiandrosterone (DHEA) and its metabolite, dehydroepiandrosterone sulfate ester (DHEAS), are circulating steroid hormones that play multiple roles in the human body. While DHEA supplementation may have benefits for postmenopausal women, such as alleviating vasomotor symptoms and preserving immune system integrity, its effects on cardiovascular disease and insulin sensitivity are still uncertain. Further research is needed to determine the physiological role, optimal dosage, and effects on women for DHEA.
Article
Biochemistry & Molecular Biology
Eleonora Persoons, Sara Kerselaers, Thomas Voets, Joris Vriens, Katharina Held
Summary: Sex hormone steroidal drugs, including pregnenolone sulphate (PS), were found to modulate the ion channel TRPM3. These drugs have both activating and inhibiting effects on TRPM3, with a common steroidal interaction site. They exhibit increased activity on TRPM3 at physiological temperatures and in channels with disease-associated mutations, providing valuable insights into TRPM3 gating and sensitivity to ligands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Barbara A. Bricker, Chandrashekhar Voshavar, Edem K. Onyameh, Uma M. Gonela, Xinsong Lin, Tracy L. Swanson, Laura B. Kozell, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: In this study, we synthesized and separated the enantiomers of SYA0340, identified their absolute configurations, and evaluated their binding affinities and functional characteristics at the 5-HT1A and 5-HT7A receptors. The results showed that both enantiomers have similar agonist properties at the 5-HT1A receptor and antagonist properties at the 5-HT7A receptor, with SYA0340-P1 displaying higher potency as a 5-HT1A receptor antagonist. Therefore, SYA0340-P1 is considered the eutomer and these enantiomers may serve as new pharmacological probes for the 5-HT1A and 5-HT7A receptors.
Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Endocrinology & Metabolism
Shelli Graham, David F. Archer, James A. Simon, Kathleen M. Ohleth, Brian Bernick
Summary: This document reviewed and summarized the reported outcomes of menopausal hormone therapy (MHT) containing different estrogens and progesterone. The results suggested that MHT with estradiol (E2) and progesterone (P4) may have a potentially better safety profile compared to other estrogens and progestins, but further research is needed due to limitations of some studies.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Cindy Z. Kalenga, Amy Metcalfe, Magali Robert, Kara A. Nerenberg, Jennifer M. MacRae, Sofia B. Ahmed
Summary: The route of estrogen administration and formulation of estrogen in hormone therapy for postmenopausal women are associated with the risk of hypertension. Oral estrogen is associated with a higher risk of hypertension, while transdermal, vaginal, or intramuscular estrogen is associated with a lower risk. Conjugated equine estrogen is associated with an increased risk, while estradiol or estrone is not. The duration and cumulative dose of estrogen use are positively associated with the risk of hypertension.
Review
Geriatrics & Gerontology
Gregory S. Walsh, Anne Delextrat, Adam Bibbey
Summary: In addition to various symptoms, menopause leads to decreased balance performance and increased risk of falls. This review aimed to assess the effects of exercise interventions on balance in perimenopausal and early postmenopausal women. Twenty-six studies were included in the analysis, and the results showed that exercise improved balance measures, with whole-body vibration being the most effective intervention. Resistance and balance training also showed improvement in balance. Exercise should be considered as an adjunct therapy for perimenopausal and postmenopausal women.
Review
Neurosciences
Meghan O. Blaya, Ami P. Raval, Helen M. Bramlett
Summary: Traumatic brain injury is a major cause of death and disability, with over 50 million people suffering from it each year. There is a lack of research on the impact of TBI on women, despite evidence of differences between males and females. It is important to understand how age and physiology affect women's susceptibility, neurological outcomes, and treatment success in order to develop targeted interventions.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Irina P. Voronova
Summary: This review discusses the influence of serotonin receptors on body temperature regulation in warm-blooded animals, covering different receptor types and their activation effects on temperature.
Review
Psychology, Clinical
Kristen M. Culbert, Katharine N. Thakkar, Kelly L. Klump
Summary: This narrative review examines the theories behind the heightened risk for psychosis in midlife women and looks at the potential role of ovarian hormones. Studies indicate that the peak ages of midlife psychosis risk in women overlap with the age range of key menopausal stages, especially the perimenopausal transition. However, there is a lack of direct research on menopausal stage. Studies on ovarian hormone effects have mostly focused on earlier developmental stages and events, showing increases in psychotic symptoms during periods of lower estradiol levels. Future research is needed to fill the gaps in our knowledge.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Hirohito Esaki, Yuki Sasaki, Naoya Nishitani, Hikari Kamada, Satoko Mukai, Yoshitaka Ohshima, Sao Nakada, Xiyan Ni, Satoshi Deyama, Katsuyuki Kaneda
Summary: This study examined whether the prosocial effects induced by MDMA are mediated by 5-HT neurotransmission in the medial prefrontal cortex (mPFC) and the basolateral nucleus of amygdala (BLA). The results showed that selective inhibition of 5-HT transporters before MDMA administration did not suppress the prosocial effects. However, the 5-HT1A receptor antagonist WAY100635 significantly suppressed the prosocial effects of MDMA. Furthermore, local administration of WAY100635 into the BLA, but not the mPFC, suppressed the MDMA-induced prosocial effects. These findings suggest that MDMA induces prosocial effects through the stimulation of 5-HT1A receptors in the BLA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Leilah K. Grant, Jamie E. Coborn, Aviva Cohn, Margo D. Nathan, Frank A. J. L. Scheer, Elizabeth B. Klerman, Ursula B. Kaiser, Jessica Harder, Mathena Abramson, Elkhansaa Elguenaoui, Julia A. Russell, Aleta Wiley, Shadab A. Rahman, Hadine Joffe
Summary: Sleep fragmentation and hypoestrogenism independently alter fasting substrate oxidation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Geriatrics & Gerontology
Andres F. Loaiza-Betancur, Ivan Chulvi-Medrano, Victor A. Diaz-Lopez, Cinta Gomez-Tomas
Summary: Exercise training is effective in reducing blood pressure in menopausal and postmenopausal women, with combined training showing the largest reductions. Aerobic training did not lead to significant improvements in this population.
Article
Behavioral Sciences
A. Ezequiel Pereyra, Camilo J. Mininni, B. Silvano Zanutto
Summary: The study demonstrates that serotonin modulates reward-driven learning, and 5-HT1A receptors in the BLA play a crucial role in extinction. Fluoxetine treatment accelerates extinction learning, while BLA lesions partially revert this effect.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Marcelo B. Generoso, Ivan Taiar, Quirino Cordeiro, Pedro Shiozawa, Siegfried Kasper
Summary: Early treatment of psychotic illness is important for better outcomes, and cariprazine, a promising antipsychotic drug, may be beneficial in treating psychosis regardless of the diagnosis of schizophrenia or bipolar disorder.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Psychiatry
Miquel Roca, Annalisa Bonelli, Agnese Cattaneo, Alessandro Comandini, Giorgio Di Dato, Franca Heiman, Valeria Pegoraro, Siegfried Kasper, Hans-Peter Volz, Diego Palao
Summary: This study explores the impact of pharmacological approaches in treating MDD patients and identifies factors associated with longer sick leave duration. Combination/switch/add-on treatments are associated with a higher risk of longer sick leave periods, while timely and careful selection of antidepressant treatment approach may help reduce sick leave.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Review
Psychiatry
Hans-Peter Volz, Johanna Stirnweiss, Siegfried Kasper, Hans-Juergen Moeller, Erich Seifritz
Summary: This paper reviews the research on subthreshold depression (SD) based on a scoping review. The results show that the operationalisation criteria used are highly heterogeneous, leading to inconsistent epidemiological data. The impact of SD on quality of life and related parameters is similar to that of major depression, and therapeutic approaches can be helpful in both preventing and treating SD.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Psychiatry
Matej Murgas, Jakob Unterholzner, Peter Stoehrmann, Cecile Philippe, Godber M. Godbersen, Lukas Nics, Murray B. Reed, Chrysoula Vraka, Thomas Vanicek, Wolfgang Wadsak, Georg S. Kranz, Andreas Hahn, Markus Mitterhauser, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger, Pia Baldinger-Melich
Summary: This study investigated the effects of TBS on the distribution of the 5-HT1A receptor in patients with TRD. PET imaging and blood sampling revealed changes in 5-HT1A receptor after treatment, which correlated with reduction in depressive symptoms.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Douglas A. Formolo, Thomas H. Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S. Kranz, Suk-Yu Yau
Summary: Sub-chronic treatment with AdipoRon has antidepressant- and anxiolytic-like effects in mice, independent of changes in hippocampal neurogenesis and synaptic plasticity.
Article
Pediatrics
J. B. Brandt, J. Golej, S. Irschik, A. Steiner, P. Voitl, I. Steiner, A. Hoeflich
Summary: This study aimed to investigate the impact of intensive care treatment on mother-child bonding for infants with congenital heart disease and how mothers cope with this situation. The results showed that mothers in the intensive care group had higher rates of postpartum depression and impaired mother-child bonding. Effective coping strategies were found to significantly influence mother-child bonding.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Roberto C. Delgado Bolton, Francesco Giammarile, David C. Howlett, Nuria Jornet, Adrian P. Brady, Mary Coffey, Monika Hierath, Jonathan Clark, Wolfgang Wadsak
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Clinical Neurology
Lucie Bartova, Markus Dold, Gernot Fugger, Ana Weidenauer, Dan Rujescu, Siegfried Kasper
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Peter Stohrmann, Godber Mathis Godbersen, Murray Bruce Reed, Jakob Unterholzner, Manfred Klobl, Pia Baldinger-Melich, Thomas Vanicek, Andreas Hahn, Rupert Lanzenberger, Siegfried Kasper, Georg S. Kranz
Summary: This longitudinal study investigated the effect of bilateral sequential theta-burst stimulation (TBS) on functional connectivity (FC) in treatment-resistant depression (TRD). Results showed that both active and sham stimulation groups exhibited reductions in depression scores, with no significant difference between the two groups. Baseline FC between the left dorsolateral prefrontal cortex (DLPFC) and the subgenual cingulate cortex (sgACC) was correlated with changes in depression severity. TBS significantly reduced FC between the left stimulation target and bilateral anterior insula, highlighting the effect on the salience network.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Clinical Neurology
Rebecca L. D. Kan, Tim T. Z. Lin, Bella B. B. Zhang, Cristian G. Giron, Minxia Jin, Penny P. I. Qin, Adam W. L. Xia, Sherry K. W. Chan, Bolton K. H. Chau, Georg S. Kranz
Editorial Material
Psychiatry
Siegfried Kasper
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Murray B. Reed, Patricia A. Handschuh, Manfred Kloebl, Melisande E. Konadu, Ulrike Kaufmann, Andreas Hahn, Georg S. Kranz, Marie Spies, Rupert Lanzenberger
Summary: This study investigated the effects of sex steroids on insular connectivity. The findings showed increased connectivity in transgender women receiving gender-affirming hormone therapy. Additionally, gender-affirming hormone therapy led to changes in alexithymia in transgender women.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Chemistry, Medicinal
Karsten Bamminger, Verena Pichler, Chrysoula Vraka, Tina Nehring, Katharina Pallitsch, Barbara Lieder, Marcus Hacker, Wolfgang Wadsak
Summary: PD-1/PD-L1 immune checkpoint blockade showed promising results in cancer therapy. However, only a small portion of PD-L1-positive tumor patients benefit from this immunotherapy. Non-invasive in vivo quantification of PD-L1 using PET imaging holds the potential to enhance patient stratification. This study synthesized and evaluated new small molecules as potential PD-L1 PET tracers.
Article
Clinical Neurology
Raphaela Muri, Stephanie Maissen-Abgottspon, Murray Bruce Reed, Roland Kreis, Maike Hoefemann, Piotr Radojewski, Katarzyna Pospieszny, Michel Hochuli, Roland Wiest, Rupert Lanzenberger, Roman Trepp, Regula Everts
Summary: Despite increasing knowledge about the effects of phenylketonuria on brain structure and function, it is uncertain whether white matter microstructure is affected and if it is linked to patients' metabolic control or cognitive performance. This study quantitatively assessed white matter characteristics in adults with phenylketonuria and their relationship to brain and blood phenylalanine levels, historical metabolic control, and cognitive performance.
BRAIN COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas Hahn, Murray Reed, Chrysoula Vraka, Godber Godbersen, Sebastian Klug, Arkadiusz Komorowski, Pia Falb, Lukas Nics, Tatjana Traub-Weidinger, Marcus Hacker, Rupert Lanzenberger
Summary: This study presents a novel approach to investigate metabolic and hemodynamic responses during cognitive processing, allowing for the examination of unique temporal information that is not accessible with conventional PET imaging techniques.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)
