Article
Neurosciences
Roberto Frau, Francesco Traccis, Luca Concas, Roberto Cadeddu, Laura J. Mosher, Peter Nordkild, Nilesh W. Gaikwad, Marco Bortolato
Summary: The neurosteroid allopregnanolone (AP) is necessary for reducing PPI in response to D-1 dopamine receptor agonists. SD rats are more susceptible to PPI deficits caused by the D-1 receptor full agonist SKF82958 when AP is administered. This suggests that AP enables the detrimental effects of D-1 receptor activation on sensorimotor gating.
PSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Dagimhiwat H. Legesse, Chen Fan, Jinfeng Teng, Yuxuan Zhuang, Rebecca J. Howard, Colleen M. Noviello, Erik Lindahl, Ryan E. Hibbs
Summary: Legesse et al. present structural studies of a human GABAA receptor in complex with positive and negative modulator neurosteroids, uncovering mechanisms of potentiation and inhibition. Allopregnanolone, a positive modulator, binds at the receptor-bilayer interface, while inhibitory neurosteroids bind in the pore. MD simulations and electrophysiology support the mechanism of allopregnanolone potentiating channel activity and suggest pore block as the dominant mechanism for sulfated neurosteroid inhibition.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Wafaa H. Mohamed, Marwa F. Ali, Doha Yahia, Hassan A. Hussein
Summary: This study evaluated the potential reproductive toxicity of sulfoxaflor (SFX) insecticide in male Sprague Dawley rats. The results showed that SFX exposure led to abnormal sperm morphology, sperm DNA damage, and significant pathological changes in the testes, epididymis, and seminal vesicles of the rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Weili Mao, Lingling Mao, Nan Zhao, Yingying Zhang, Meirong Zhao, Hangbiao Jin
Summary: This study investigated the occurrence of free Bisphenol S (BPS) and its conjugated metabolites in rat internal tissues, blood, and excreta after continuous BPS dosage. The results showed that concentrations of free BPS and its metabolites reached steady state after 9 days of continuous dosage. The study also found that analyzing human blood and urine may not accurately reflect the contamination of BPS metabolites in human internal tissues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Verica Milivojevic, Lily Charron, Nia Fogelman, Gretchen Hermes, Rajita Sinha
Summary: Chronic cocaine use leads to adaptations in stress biology and the neuroactive steroid system. The study found that pregnenolone, a precursor to neuroactive steroids, decreases cocaine craving and anxiety, as well as reduces stress-induced autonomic arousal in individuals with cocaine use disorder.
Article
Pharmacology & Pharmacy
Farah Hanan Fathihah Jaffar, Khairul Osman, Chua Kien Hui, Aini Farzana Zulkefli, Siti Fatimah Ibrahim
Summary: The study found that supplementation with 250 mg/kg BW/d of EBN showed a significant increase in sperm concentration, sperm motility, FSH, and LH levels compared to the group receiving 10 mg/kg BW/d. There was a dose-dependent increase in testosterone level, but it was not significant between groups. In conclusion, EBN was found to have significant effects on male reproductive parameters.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Andrea N. Wang, Joselia Carlos, Krishna K. Singh, Graham M. Fraser, John J. McGuire
Summary: In this study, endothelial dysfunction and altered expression of endothelial genes in type 2 diabetes were examined using ZDSD rats as a model. The results showed that ZDSD rats exhibited endothelial dysfunction and increased sensitivity to PAR2 agonist-induced vasodilation. Additionally, altered expression of multiple endothelial genes, including PAR2, suggested the involvement of inflammatory and angiogenesis signaling pathways in the endothelium of ZDSD rats.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Silvia Diviccaro, Silvia Giatti, Lucia Cioffi, Eva Falvo, Rocco Piazza, Donatella Caruso, Roberto C. Melcangi
Summary: This study found that paroxetine has a biphasic effect on the gut, affecting both steroidogenesis and the gut microbiota. The steroid modifications observed immediately after treatment are different from those detected at withdrawal.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rachel Ward-Flanagan, Alto S. Lo, Elizabeth A. Clement, Clayton T. Dickson
Summary: Anesthesia is a powerful tool in neuroscientific research, particularly in sleep research. The choice of anesthesia can have differential effects on brain states and neurophysiological factors, highlighting the importance of careful selection to avoid confounding brain states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Matthew A. Hartog, Rebecca J. Lewandowski, Christopher S. Hofmann, Ashley A. Melber, Cristin C. Rothwell, Katherine Sherman, Jaclynn Andres, Justin A. Tressler, Alfred M. Sciuto, Benjamin Wong, Heidi M. Hoard-Fruchey
Summary: Phosphine (PH3) is a highly toxic gas commonly used as a fumigant, causing multiorgan toxicity with no effective antidotes identified. Transcriptomic analysis revealed concentration- and time-dependent gene expression changes linked to cardiotoxicity pathways, aiding in understanding the precise mechanism of PH3 toxicity and development of medical countermeasures.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Behavioral Sciences
John Michael Holden
Summary: Relapse into addiction can be triggered by cues associated with drug use. Sign-tracking, the approach and interaction with Pavlovian conditioned signals, may contribute to cue-driven relapse. Bupropion, an antidepressant, was found to decrease sign-tracking and increase goal-tracking in rats, suggesting its potential as an adjunct medication for behavioral disorders involving cue-driven behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ahmad Safiyyu'd-din Bin Hisamuddin, Ruth Naomi, Khairul Aiman Bin Manan, Hasnah Bahari, Muhammad Dain Yazid, Fezah Othman, Hashim Embong, Siti Hadizah Jumidil, Mohd Khairi Hussain, Zainul Amiruddin Zakaria
Summary: This study assessed the toxicity of lutein-rich purple sweet potato leaf (PSPL) extract in male Sprague-Dawley rats. The results showed that at a dosage of 2,000 mg/kg/d, the PSPL extract did not exhibit any signs of toxicity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Guowei Chen, Zixin Yang, Chunting Cao, Xue Xiao, Yadong Huang, Lingmin Tian, Weibin Bai
Summary: The study found that oral administration of the recombinant Lactococcus lactis strain pGSMT/MG1363 for 6 weeks did not have adverse effects on the physiological parameters and gut microbial compositions of rats, indicating that its stability may be considered safe compared to the non-GM strain MG1363.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Multidisciplinary Sciences
Rachel Ward-Flanagan, Clayton T. Dickson
Summary: The analgesic efficacy of chloral hydrate was evaluated using the intravenous route of administration. The results showed that under chloral hydrate anesthesia, tail withdrawal latencies were significantly prolonged with unchanged heart and respiration rates, indicating excellent analgesic depth and efficacy for surgical manipulations.
Article
Food Science & Technology
Tongtong Ma, Qian Sun, Gen-na Ba, Xuan Wu, Xingwu Pei, Chao Sun, Shengjie Tan, Zhongxiao Wan
Summary: This study compared the effects of low phytate soymilk and regular soymilk consumption on long-term mineral status using rodent models. The results showed that both soymilk and low phytate soymilk increased serum calcium, hemoglobin, transferrin, and femur zinc levels compared to the control group. However, the soymilk group had decreased serum iron, red cell distribution width, and zinc levels. In addition, the low phytate soymilk group had significantly higher serum and liver zinc levels compared to the soymilk group. Furthermore, low phytate soymilk improved bone quality, maintained circulating iron and zinc levels, and increased liver iron storage compared to regular soymilk. Further studies on human subjects are needed to explore the effects of low phytate soymilk consumption on calcium, iron, and zinc status.
JOURNAL OF FUNCTIONAL FOODS
(2023)
