Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frontiers in therapeutic development of allopregnanolone for Alzheimer’s disease and other neurological disorders

(2014) Ronald W. Irwin et al.   Frontiers in Cellular Neuroscience

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Neuroactive steroids for the treatment of status epilepticus

(2013) Michael A. Rogawski et al.   EPILEPSIA

Neurosteroids as regenerative agents in the brain: therapeutic implications

(2013) Roberta D. Brinton   Nature Reviews Endocrinology

Allopregnanolone as regenerative therapeutic for Alzheimer's disease: Translational development and clinical promise

(2013) Ronald W. Irwin et al.   PROGRESS IN NEUROBIOLOGY

cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels

(2013) Guilherme Lepski et al.   Frontiers in Cellular Neuroscience

Of mice and men: neurogenesis, cognition and Alzheimer’s disease

(2013) Orly Lazarov et al.   Frontiers in Aging Neuroscience

Age-related changes in neuroactive steroid levels in 3xTg-AD mice

(2012) Donatella Caruso et al.   NEUROBIOLOGY OF AGING

GABA-mediated induction of early neuronal markers expression in postnatal rat progenitor cells in culture

(2012) M. Ramírez et al.   NEUROSCIENCE

Neurosteroids, stress and depression: Potential therapeutic opportunities

(2012) Charles F. Zorumski et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Allopregnanolone Promotes Regeneration and Reduces β-Amyloid Burden in a Preclinical Model of Alzheimer's Disease

(2011) Shuhua Chen et al.   PLoS One

A history of depression in women is associated with an altered GABAergic neuroactive steroid profile

(2011) Susan S. Girdler et al.   PSYCHONEUROENDOCRINOLOGY

Effect of Short-and Long-Term Gonadectomy on Neuroactive Steroid Levels in the Central and Peripheral Nervous System of Male and Female Rats

(2010) D. Caruso et al.   JOURNAL OF NEUROENDOCRINOLOGY

Review of the Basic and Clinical Pharmacology of Sulfobutylether-β-Cydodextrin (SBECD)

(2010) David R. Luke et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years

(2010) Rolf Knoth et al.   PLoS One

Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

(2010) J. M. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The basics of preclinical drug development for neurodegenerative disease indications

(2009) Karen L Steinmetz et al.   BMC Neurology

Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential

(2009) Jun Wang et al.   BMC NEUROSCIENCE

GABA synthesis in Schwann cells is induced by the neuroactive steroid allopregnanolone

(2009) Valerio Magnaghi et al.   JOURNAL OF NEUROCHEMISTRY

Allopregnanolone has no effect on startle response and prepulse inhibition of startle response in patients with premenstrual dysphoric disorder or healthy controls

(2009) Kristiina Kask et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone

(2008) Stefania Zampieri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Neuroactive Steroid Stereospecificity of Ethanol-Like Discriminative Stimulus Effects in Monkeys

(2008) K. A. Grant et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Allopregnanolone impairs episodic memory in healthy women

(2008) Kristiina Kask et al.   PSYCHOPHARMACOLOGY

Cyclodextrins

(2008) Valentino J. Stella et al.   TOXICOLOGIC PATHOLOGY