Journal
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
Volume 30, Issue 4, Pages 421-430Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1533317514556874
Keywords
mild cognitive impairment; testosterone treatment; verbal memory; cognition; quality of life; low serum testosterone
Categories
Funding
- NIA [AG027156]
- VA Puget Sound Health Care System, Seattle, WA
- University of Washington, Seattle, WA
- Abbott Laboratories
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Introduction: This study investigated the effects of testosterone (T) treatment on cognition, mood, and quality of life in men with mild cognitive impairment (MCI) and low serum T levels. Methods: A total of 351 community-dwelling men were screened, and 37 men evidenced both MCI and low T of whom 27 agreed for further screening. Twenty-two met all the study inclusion/exclusion criteria and enrolled in a 6-month randomized, double-blind, placebo-controlled study. Results: Total T levels significantly increased in the T treatment group. No significant changes were observed in measures of cognition, mood, or quality of life other than improvement in 1 objective measure of verbal memory (P < .05) and decreased depression symptoms (P < .02) in the treatment group. Conclusions: Testosterone treatment may modestly improve verbal memory and depression symptoms in men with both MCI and low T.
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