TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes

(2016) Ryota Nakayama et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ca2+transients in astrocyte fine processes occur via Ca2+influx in the adult mouse hippocampus

(2016) Ravi L. Rungta et al.   GLIA

Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease

(2016) Kuan-I Lee et al.   Journal of Neuroinflammation

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

(2016) Ming Lei et al.   NEUROBIOLOGY OF DISEASE

Neuronal hyperactivity - A key defect in Alzheimer's disease?

(2015) Marc Aurel Busche et al.   BIOESSAYS

Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

(2015) Verónica Abudara et al.   GLIA

Ca2+ signaling in astrocytes from Ip3r2 −/− mice in brain slices and during startle responses in vivo

(2015) Rahul Srinivasan et al.   NATURE NEUROSCIENCE

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway

(2014) Martin D. Haustein et al.   NEURON

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors

(2014) Edina Varga et al.   NEURAL PLASTICITY

Subcellular location of astrocytic calcium stores favors extrasynaptic neuron–astrocyte communication

(2013) Ilya Patrushev et al.   CELL CALCIUM

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses

(2013) Eiji Shigetomi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Amyloid- 1-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

(2013) A. Scimemi et al.   JOURNAL OF NEUROSCIENCE

TRPA1 Channels Are Regulators of Astrocyte Basal Calcium Levels and Long-Term Potentiation via Constitutive D-Serine Release

(2013) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

(2013) Tiina Maria Pirttimaki et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus

(2012) Sang Man Lee et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Astrocyte-Originated ATP Protects A 1-42-Induced Impairment of Synaptic Plasticity

(2012) E. S. Jung et al.   JOURNAL OF NEUROSCIENCE

The transient receptor potential channel TRPA1: from gene to pathophysiology

(2012) Bernd Nilius et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Bulk Loading of Calcium Indicator Dyes to Study Astrocyte Physiology: Key Limitations and Improvements Using Morphological Maps

(2011) A. M. B. Reeves et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3

(2011) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

Local Ca2+ detection and modulation of synaptic release by astrocytes

(2011) Maria Amalia Di Castro et al.   NATURE NEUROSCIENCE

Mapping of fluorescent protein-expressing neurons and axon pathways in adult and developing Thy1-eYFP-H transgenic mice

(2010) Cesar Porrero et al.   BRAIN RESEARCH

Mechanisms of glutamate release from astrocytes

(2007) Erik B. Malarkey et al.   NEUROCHEMISTRY INTERNATIONAL