Structural basis for GABAA receptor potentiation by neurosteroids

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

(2016) Ákos Nemecz et al.   NEURON

Hydrophobic Gating in Ion Channels

(2015) Prafulla Aryal et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

(2015) Xin Huang et al.   NATURE

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

Structural classification of steroid-binding sites on proteins by coarse-grained atomic environment and its correlation with their biological function

(2015) Yasuha Hori-Tanaka et al.   STEROIDS

The desensitization gate of inhibitory Cys-loop receptors

(2015) Marc Gielen et al.   Nature Communications

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

A general protocol for the generation of Nanobodies for structural biology

(2014) Els Pardon et al.   Nature Protocols

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Expression of recombinant glycoproteins in mammalian cells: towards an integrative approach to structural biology

(2013) A Radu Aricescu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gating Movement of Acetylcholine Receptor Caught by Plunge-Freezing

(2012) Nigel Unwin et al.   JOURNAL OF MOLECULAR BIOLOGY

A neurosteroid potentiation site can be moved among GABAAreceptor subunits

(2012) John R. Bracamontes et al.   JOURNAL OF PHYSIOLOGY-LONDON

Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

(2012) Stephen G. Brickley et al.   NEURON

Current trends in α-helical membrane protein crystallization: An update

(2012) Joanne L. Parker et al.   PROTEIN SCIENCE

A Fluorescence-Detection Size-Exclusion Chromatography-Based Thermostability Assay for Membrane Protein Precrystallization Screening

(2012) Motoyuki Hattori et al.   STRUCTURE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABAA Receptors

(2011) J. Sarkar et al.   JOURNAL OF NEUROSCIENCE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A llama-derived gelsolin single-domain antibody blocks gelsolin–G-actin interaction

(2010) Anske Van den Abbeele et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evolution of steroid receptors from an estrogen-sensitive ancestral receptor

(2010) Geeta N. Eick et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Histamine Action on Vertebrate GABAAReceptors

(2008) Arunesh Saras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT3and GABA ρ1 Receptors Lacking the Large Cytoplasmic M3M4 Loop

(2008) Michaela Jansen et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mutations of the GABA-A Receptor  1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids

(2008) G. Akk et al.   MOLECULAR PHARMACOLOGY

GABAAR Plasticity during Pregnancy: Relevance to Postpartum Depression

(2008) Jamie Maguire et al.   NEURON