Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples

(2016) Anna K. Gillespie et al.   NEURON

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

BDNF prevents amyloid-dependent impairment of LTP in the entorhinal cortex by attenuating p38 MAPK phosphorylation

(2015) Chiara Criscuolo et al.   NEUROBIOLOGY OF AGING

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

(2015) Kaoru Yamamoto et al.   Cell Reports

Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI

(2014) Adam M. Brickman et al.   BEHAVIOURAL NEUROLOGY

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice

(2014) Rebecca C. Klein et al.   NEUROBIOLOGY OF AGING

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

(2013) Ori Liraz et al.   Molecular Neurodegeneration

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits

(2013) Keigo Kohara et al.   NATURE NEUROSCIENCE

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice

(2012) Jesse M. Hunter et al.   BRAIN RESEARCH

Effect of Mild Cognitive Impairment and APOE Genotype on Resting Cerebral Blood Flow and its Association with Cognition

(2012) Christina E Wierenga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

R6/2 Huntington's Disease Mice Develop Early and Progressive Abnormal Brain Metabolism and Seizures

(2012) E. Cepeda-Prado et al.   JOURNAL OF NEUROSCIENCE

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Cellular properties of principal neurons in the rat entorhinal cortex. I. The lateral entorhinal cortex

(2011) Cathrin B. Canto et al.   HIPPOCAMPUS

Relationships between Hippocampal Sharp Waves, Ripples, and Fast Gamma Oscillation: Influence of Dentate and Entorhinal Cortical Activity

(2011) D. Sullivan et al.   JOURNAL OF NEUROSCIENCE

Segmentation of the mouse hippocampal formation in magnetic resonance images

(2011) Kay Richards et al.   NEUROIMAGE

Increased Size and Stability of CA1 and CA3 Place Fields in HCN1 Knockout Mice

(2011) Syed A. Hussaini et al.   NEURON

Elemental formula annotation of polar and lipophilic metabolites using13C,15N and34S isotope labelling, in combination with high-resolution mass spectrometry

(2011) Patrick Giavalisco et al.   PLANT JOURNAL

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease

(2010) Yakeel T. Quiroz et al.   ANNALS OF NEUROLOGY

Functional Genomics of Brain Aging and Alzheimers Disease: Focus on Selective Neuronal Vulnerability

(2010) Xinkun Wang et al.   CURRENT GENOMICS

The effects of APOE-ε4 on the BOLD response

(2010) Aaron J. Trachtenberg et al.   NEUROBIOLOGY OF AGING

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

(2010) Reza M. Salek et al.   NEUROCHEMISTRY INTERNATIONAL

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Relative Capability of MR Imaging and FDG PET to Depict Changes Associated with Prodromal and Early Alzheimer Disease

(2010) David S. Karow et al.   RADIOLOGY

Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

(2010) Yadong Huang   TRENDS IN MOLECULAR MEDICINE

Distinct patterns of brain activity in young carriers of the APOE- 4 allele

(2009) N. Filippini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH

Human Apolipoprotein E4 Targeted Replacement Mice Show Increased Prevalence of Intracerebral Hemorrhage Associated with Vascular Amyloid Deposition

(2008) Patrick M. Sullivan et al.   Journal of Stroke & Cerebrovascular Diseases

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Cerebral perfusion and oxygenation differences in Alzheimer's disease risk

(2008) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE