Exocyclic Olefinic Maleimides: Synthesis and Application for Stable and Thiol-Selective Bioconjugation

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Allenamides as Orthogonal Handles for Selective Modification of Cysteine in Peptides and Proteins

(2014) Ata Abbas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cysteine-Selective Reactions for Antibody Conjugation

(2014) Pedro M. S. D. Cal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Developments in the Field of Bioorthogonal Bond Forming Reactions—Past and Present Trends

(2014) Mathias King et al.   BIOCONJUGATE CHEMISTRY

Long-Term Stabilization of Maleimide–Thiol Conjugates

(2014) Shaun D. Fontaine et al.   BIOCONJUGATE CHEMISTRY

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Iridium-Catalyzed Asymmetric Hydrogenation of α-Alkylidene Succinimides

(2013) Yuanyuan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid, Stable, Chemoselective Labeling of Thiols with Julia-Kocieński-like Reagents: A Serum-Stable Alternative to Maleimide-Based Protein Conjugation

(2013) Narihiro Toda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Reagent for Stable Thiol-Specific Conjugation

(2013) George Badescu et al.   BIOCONJUGATE CHEMISTRY

Highly Chemoselective Rauhut–Currier Reaction between Maleimides and Enones and Dual Phosphine-Mediated One-Pot Synthesis of Bicyclic and Polycyclic Skeletons

(2013) Rong Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Back on target

(2013) Sarah Webb   NATURE BIOTECHNOLOGY

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments

(2011) Aaron D. Baldwin et al.   BIOCONJUGATE CHEMISTRY

Choosing an effective protein bioconjugation strategy

(2011) Nicholas Stephanopoulos et al.   Nature Chemical Biology

Bicyclic Guanidine-Catalyzed Direct Asymmetric Allylic Addition of N-Aryl Alkylidene-Succinimides

(2010) Jianmin Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines

(2010) K. Karthikeyan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

(2010) Mark E. B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of (Z)-5-(4-Methoxybenzylidene)thiazolidine-2,4-dione, a Readily Available and Orally Active Glitazone for the Treatment of Concanavalin A-Induced Acute Liver Injury of BALB/c Mice

(2009) Youfu Luo et al.   JOURNAL OF MEDICINAL CHEMISTRY

General Strategy for the Synthesis of Natural and Unnatural Dialkylmaleic Anhydrides

(2008) Kishan P. Haval et al.   JOURNAL OF ORGANIC CHEMISTRY