Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome

Site-Specific Conjugation of Peptides and Proteins via Rebridging of Disulfide Bonds Using the Thiol–Yne Coupling Reaction

(2016) Nils Griebenow et al.   BIOCONJUGATE CHEMISTRY

Rewiring Gram-Negative Bacteria Cell Surfaces with Bio-Orthogonal Chemistry via Liposome Fusion

(2016) Sina Elahipanah et al.   BIOCONJUGATE CHEMISTRY

Chemical Protein Modification through Cysteine

(2016) Smita B. Gunnoo et al.   CHEMBIOCHEM

Erratum: Corrigendum: Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines

(2016) Daniel A. Richards et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Water-soluble allyl sulfones for dual site-specific labelling of proteins and cyclic peptides

(2016) Tao Wang et al.   Chemical Science

Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry

(2016) Padma Akkapeddi et al.   Chemical Science

Next-generation disulfide stapling: reduction and functional re-bridging all in one

(2016) Maximillian T. W. Lee et al.   Chemical Science

The use of 3,6-pyridazinediones in organic synthesis and chemical biology

(2016) Maximillian T. W. Lee et al.   JOURNAL OF CHEMICAL RESEARCH

Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation

(2015) Joanna B. Pawlak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Situ Conjugation of Dithiophenol Maleimide Polymers and Oxytocin for Stable and Reversible Polymer–Peptide Conjugates

(2015) Jennifer Collins et al.   BIOCONJUGATE CHEMISTRY

Site-selective in situ growth of fluorescent polymer–antibody conjugates with enhanced antigen detection by signal amplification

(2015) Libin Zhang et al.   BIOMATERIALS

Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications

(2015) Tao Wang et al.   CHEMICAL COMMUNICATIONS

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

(2015) Antoine Maruani et al.   CHEMICAL COMMUNICATIONS

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

(2015) João P. M. Nunes et al.   CHEMICAL COMMUNICATIONS

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Organic Arsenicals As Efficient and Highly Specific Linkers for Protein/Peptide–Polymer Conjugation

(2015) Paul Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stimuli-Responsive Nanomaterials for Biomedical Applications

(2015) Angela P. Blum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

(2015) Christopher R. Behrens et al.   MOLECULAR PHARMACEUTICS

In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab–MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios

(2015) Penny Bryant et al.   MOLECULAR PHARMACEUTICS

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

(2015) James I MacDonald et al.   Nature Chemical Biology

A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging

(2015) Sally A. Fletcher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

(2015) Mark E. B. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

Programming Bioactive Architectures with Cyclic Peptide Amphiphiles

(2015) Seah Ling Kuan et al.   ChemPlusChem

Protein–polymer therapeutics: a macromolecular perspective

(2015) Yuzhou Wu et al.   Biomaterials Science

Programming Supramolecular Biohybrids as Precision Therapeutics

(2014) David Yuen Wah Ng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bridging Disulfides for Stable and Defined Antibody Drug Conjugates

(2014) George Badescu et al.   BIOCONJUGATE CHEMISTRY

Homogeneous Bispecifics by Disulfide Bridging

(2014) Elizabeth A. Hull et al.   BIOCONJUGATE CHEMISTRY

Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment

(2014) Francesca Bryden et al.   BIOCONJUGATE CHEMISTRY

Antibody–drug conjugates—A new wave of cancer drugs

(2014) Hervé Bouchard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Site-Specific Dual Labeling of Proteins by Using Small Orthogonal Tags at Neutral pH

(2014) Jan Grünewald et al.   CHEMBIOCHEM

Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds

(2014) Cristina Marculescu et al.   CHEMICAL COMMUNICATIONS

A Disulfide Intercalator Toolbox for the Site-Directed Modification of Polypeptides

(2014) Tao Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photoclick chemistry: a fluorogenic light-triggered in vivo ligation reaction

(2014) Carlo P Ramil et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

More than add-on: chemoselective reactions for the synthesis of functional peptides and proteins

(2014) Dominik Schumacher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Stimuli-sensitive nanopreparations for combination cancer therapy

(2014) Aditi Jhaveri et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis, Characterization, and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy

(2014) Angelo Frei et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Terminal Modification of Proteins with o-Aminophenols

(2014) Allie C. Obermeyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gradated assembly of multiple proteins into supramolecular nanomaterials

(2014) Gregory A. Hudalla et al.   NATURE MATERIALS

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

(2014) Felix F. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces

(2014) S. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clickable Tyrosine Binding Bifunctional Linkers for Preparation of DNA–Protein Conjugates

(2013) Dennis M. Bauer et al.   BIOCONJUGATE CHEMISTRY

One-pot squaric acid diester mediated aqueous protein conjugation

(2013) Frederik Wurm et al.   CHEMICAL COMMUNICATIONS

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation

(2013) Lourdes Castañeda et al.   CHEMICAL COMMUNICATIONS

Bis-sulfide bioconjugates for glutathione triggered tumor responsive drug release

(2013) Tao Wang et al.   CHEMICAL COMMUNICATIONS

Conjugation-Induced Fluorescent Labeling of Proteins and Polymers Using Dithiomaleimides

(2013) Mathew P. Robin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photo-Induced Ligation of Acrylonitrile-Butadiene Rubber: Selective Tetrazole–Ene Coupling of Chain-End-Functionalized Copolymers of 1,3-Butadiene

(2013) Christoph J. Dürr et al.   MACROMOLECULES

Evolution and functional cross-talk of protein post-translational modifications

(2013) Pedro Beltrao et al.   Molecular Systems Biology

Sustained gastrointestinal activity of dendronized polymer–enzyme conjugates

(2013) Gregor Fuhrmann et al.   Nature Chemistry

Sunlight-induced crosslinking of 1,2-polybutadienes: access to fluorescent polymer networks

(2013) Jan O. Mueller et al.   Polymer Chemistry

Functional polypeptide and hybrid materials: Precision synthesis via α-amino acid N-carboxyanhydride polymerization and emerging biomedical applications

(2013) Chao Deng et al.   PROGRESS IN POLYMER SCIENCE

Cross-conjugation of DNA, proteins and peptides via a pH switch

(2013) Tao Wang et al.   Chemical Science

Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’

(2013) Felix F. Schumacher et al.   Scientific Reports

Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications

(2013) Shirley Wong et al.   Journal of Materials Chemistry B

Pharmacokinetic, Biodistribution, and Biophysical Profiles of TNF Nanobodies Conjugated to Linear or Branched Poly(ethylene glycol)

(2012) Yulia Vugmeyster et al.   BIOCONJUGATE CHEMISTRY

Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

(2012) Mathew W. Jones et al.   CHEMICAL COMMUNICATIONS

Metal Ion Controlled Self-Assembly of a Chemically Reengineered Protein Drug Studied by Small-Angle X-ray Scattering

(2012) Jesper Nygaard et al.   LANGMUIR

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Site-Specific Labeling of scVEGF with Fluorine-18 for Positron Emission Tomography Imaging

(2012) Hui Wang et al.   Theranostics

Synthesis and Activity of Thioether-Containing Analogues of the Complement Inhibitor Compstatin

(2011) Patrick J. Knerr et al.   ACS Chemical Biology

Photoclickable Surfaces for Profluorescent Covalent Polymer Coatings

(2011) Mathias Dietrich et al.   ADVANCED FUNCTIONAL MATERIALS

In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation

(2011) Felix F. Schumacher et al.   BIOCONJUGATE CHEMISTRY

Bromomaleimide-Linked Bioconjugates Are Cleavable in Mammalian Cells

(2011) Paul Moody et al.   CHEMBIOCHEM

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

(2011) Chris P. Ryan et al.   CHEMICAL COMMUNICATIONS

Bromopyridazinedione-mediated protein and peptide bioconjugation

(2011) Vijay Chudasama et al.   CHEMICAL COMMUNICATIONS

Adapting to Substrate Challenges: Peptides as Catalysts for Conjugate Addition Reactions of Aldehydes to α,β-Disubstituted Nitroolefins

(2011) Jörg Duschmalé et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bioactive Unnatural Somatostatin Analogues through Bioorthogonal Iodo- and Ethynyl-Disulfide Intercalators

(2011) Anne Pfisterer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antibody–enzyme fusion proteins for cancer therapy

(2011) Carima Andrady et al.   Immunotherapy

Nanoparticle Shape Anisotropy Dictates the Collective Behavior of Surface-Bound Ligands

(2011) Matthew R. Jones et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Choosing an effective protein bioconjugation strategy

(2011) Nicholas Stephanopoulos et al.   Nature Chemical Biology

Delivery of Therapeutic Proteins

(2010) Dipak S. Pisal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Tyrosine Bioconjugation through Aqueous Ene-Type Reactions: A Click-Like Reaction for Tyrosine

(2010) Hitoshi Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

(2010) Mark E. B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast Alkene Functionalization In Vivo by Photoclick Chemistry: HOMO Lifting of Nitrile Imine Dipoles

(2009) Yizhong Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Probing Protein Folding Using Site-Specifically Encoded Unnatural Amino Acids as FRET Donors with Tryptophan

(2009) Shigeki J. Miyake-Stoner et al.   BIOCHEMISTRY

Towards functional bionanomaterials based on self-assembling cyclic peptidenanotubes

(2009) Roberto J. Brea et al.   CHEMICAL SOCIETY REVIEWS

Potent antibody drug conjugates for cancer therapy

(2009) Peter D Senter   CURRENT OPINION IN CHEMICAL BIOLOGY

Emerging peptide nanomedicine to regenerate tissues and organs

(2009) M. J. Webber et al.   JOURNAL OF INTERNAL MEDICINE

Peptide/protein–polymer conjugates: synthetic strategies and design concepts

(2008) Marc A. Gauthier et al.   CHEMICAL COMMUNICATIONS

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

Disulfide bridge based PEGylation of proteins

(2007) Steve Brocchini et al.   ADVANCED DRUG DELIVERY REVIEWS