Site-Selective Cysteine-Cyclooctyne Conjugation

Library Design-Facilitated High-Throughput Sequencing of Synthetic Peptide Libraries

(2017) Alexander A. Vinogradov et al.   ACS Combinatorial Science

A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylation

(2017) Peng Dai et al.   Scientific Reports

Site-Specific Conjugation of Peptides and Proteins via Rebridging of Disulfide Bonds Using the Thiol–Yne Coupling Reaction

(2016) Nils Griebenow et al.   BIOCONJUGATE CHEMISTRY

Synthesis of Site-Specific Radiolabeled Antibodies for Radioimmunotherapy via Genetic Code Expansion

(2016) Yiming Wu et al.   BIOCONJUGATE CHEMISTRY

Sequence-Specific 2-Cyanobenzothiazole Ligation

(2016) Carlo P. Ramil et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Salt Effect Accelerates Site-Selective Cysteine Bioconjugation

(2016) Peng Dai et al.   ACS Central Science

Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates

(2015) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells

(2015) Takashi Kawakami et al.   CHEMISTRY & BIOLOGY

Site-selective protein-modification chemistry for basic biology and drug development

(2015) Nikolaus Krall et al.   Nature Chemistry

π-Clamp-mediated cysteine conjugation

(2015) Chi Zhang et al.   Nature Chemistry

Selective Irreversible Chemical Tagging of Cysteine with 3-Arylpropiolonitriles

(2014) Oleksandr Koniev et al.   BIOCONJUGATE CHEMISTRY

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System

(2014) Erik S. Zimmerman et al.   BIOCONJUGATE CHEMISTRY

Asymmetric catalysis with short-chain peptides

(2014) Bartosz Lewandowski et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Thiol-yne ‘click’/coupling chemistry and recent applications in polymer and materials synthesis and modification

(2014) Andrew B. Lowe   POLYMER

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol–alkyne addition

(2013) Stefanie Sommer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

(2013) Reggy Ekkebus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thiol–yne radical reaction mediated site-specific protein labeling via genetic incorporation of an alkynyl-l-lysine analogue

(2013) Yiming Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Preventing Thiol-Yne Addition Improves the Specificity of Strain-Promoted Azide–Alkyne Cycloaddition

(2012) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments

(2011) Aaron D. Baldwin et al.   BIOCONJUGATE CHEMISTRY

Multi-molecule reaction of serum albumin can occur through thiol-yne coupling

(2011) Mauro Lo Conte et al.   CHEMICAL COMMUNICATIONS

Thiol-Yne Chemistry: A Powerful Tool for Creating Highly Functional Materials

(2010) Richard Hoogenboom   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Live-Cell Imaging of Cellular Proteins by a Strain-Promoted Azide-Alkyne Cycloaddition

(2010) Kimberly E. Beatty et al.   CHEMBIOCHEM

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Photoinduced Addition of Glycosyl Thiols to Alkynyl Peptides: Use of Free-Radical Thiol−Yne Coupling for Post-Translational Double-Glycosylation of Peptides

(2010) Mauro Lo Conte et al.   JOURNAL OF ORGANIC CHEMISTRY

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electron-Deficient Alkynes as Cleavable Reagents for the Modification of Cysteine-Containing Peptides in Aqueous Medium

(2009) Hoi-Yan Shiu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemoselective modification of proteins: hitting the target

(2008) Isaac S. Carrico   CHEMICAL SOCIETY REVIEWS

Selective Recognition of Protein Tetraserine Motifs with a Cell-Permeable, Pro-fluorescent Bis-boronic Acid

(2008) Tiffany L. Halo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

(2008) S. T. Laughlin et al.   SCIENCE