Unnatural amino acid incorporation in E. coli: current and future applications in the design of therapeutic proteins

Replacing Antibodies: Engineering New Binding Proteins

(2013) Scott Banta et al.   Annual Review of Biomedical Engineering

A Versatile Platform for Single- and Multiple-Unnatural Amino Acid Mutagenesis in Escherichia coli

(2013) Abhishek Chatterjee et al.   BIOCHEMISTRY

Release Factor One Is Nonessential in Escherichia coli

(2012) David B. F. Johnson et al.   ACS Chemical Biology

Reprogramming the Genetic Code: From Triplet to Quadruplet Codes

(2012) Kaihang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rewiring translation - Genetic code expansion and its applications

(2012) Heinz Neumann   FEBS LETTERS

Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements

(2012) Chung-Jr Huang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design

(2012) V. S. Terra et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Synthesis of Bispecific Antibodies using Genetically Encoded Unnatural Amino Acids

(2012) Chan Hyuk Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

(2012) J. Y. Axup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficientin VivoIncorporation of Structurally Divergent Non-native Amino Acids

(2011) Jeffrey K. Takimoto et al.   ACS Chemical Biology

A Traceless Vascular-Targeting Antibody-Drug Conjugate for Cancer Therapy

(2011) Gonçalo J. L. Bernardes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Evolved Aminoacyl-tRNA Synthetase with Atypical Polysubstrate Specificity,

(2011) Douglas D. Young et al.   BIOCHEMISTRY

Tuned Escherichia coli as a host for the expression of disulfide-rich proteins

(2011) Gustavo Salinas et al.   Biotechnology Journal

Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Traceless and Site-Specific Ubiquitination of Recombinant Proteins

(2011) Satpal Virdee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites

(2011) David B F Johnson et al.   Nature Chemical Biology

Optimized clinical performance of growth hormone with an expanded genetic code

(2011) H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

(2011) Farren J. Isaacs et al.   SCIENCE

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

LPS removal from an E. coli fermentation broth using aqueous two-phase micellar system

(2010) André M. Lopes et al.   BIOTECHNOLOGY PROGRESS

Bioorthogonal chemistry: recent progress and future directions

(2010) Reyna K. V. Lim et al.   CHEMICAL COMMUNICATIONS

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening

(2010) Yariv Mazor et al.   FEBS Journal

Delivery of Therapeutic Proteins

(2010) Dipak S. Pisal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

“Inclonals”

(2010) Rahely Hakim et al.   mAbs

Bispecific antibodies for cancer therapy

(2010) Patrick Chames et al.   mAbs

Comprehensive engineering of Escherichia coli for enhanced expression of IgG antibodies

(2010) Tomohiro Makino et al.   METABOLIC ENGINEERING

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

(2010) Heinz Neumann et al.   NATURE

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

(2010) Satpal Virdee et al.   Nature Chemical Biology

A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation

(2010) Flavio Schwarz et al.   Nature Chemical Biology

Codon reassignment in the Escherichia coli genetic code

(2010) T. Mukai et al.   NUCLEIC ACIDS RESEARCH

Product development issues for PEGylated proteins

(2010) Robert W. Payne et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Steric and thermodynamic limits of design for the incorporation of large unnatural amino acids in aminoacyl-tRNA synthetase enzymes

(2010) Roger S. Armen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutagenesis and Evolution of Sulfated Antibodies Using an Expanded Genetic Code

(2009) Chang C. Liu et al.   BIOCHEMISTRY

Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules

(2009) Michael D. Best   BIOCHEMISTRY

Nonnatural Amino Acids for Site-Specific Protein Conjugation

(2009) Albert J. de Graaf et al.   BIOCONJUGATE CHEMISTRY

One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases

(2009) Charles E. Melançon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and development of biopharmaceuticals: current issues

(2009) William R Strohl et al.   CURRENT OPINION IN BIOTECHNOLOGY

Potent antibody drug conjugates for cancer therapy

(2009) Peter D Senter   CURRENT OPINION IN CHEMICAL BIOLOGY

An Enhanced System for Unnatural Amino Acid Mutagenesis in E. coli

(2009) Travis S. Young et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetically EncodingNϵ-Methyl-l-lysine in Recombinant Histones

(2009) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of Proteins with Genetically Encoded “Chemical Warheads”

(2009) Chang C. Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation

(2009) Heinz Neumann et al.   MOLECULAR CELL

Molecular mechanisms of MHC class I abnormalities and APM components in human tumors

(2008) Barbara Seliger   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

In vivoIncorporation of Unnatural Amino Acids to Probe Structure, Dynamics, and Ligand Binding in a Large Protein by Nuclear Magnetic Resonance Spectroscopy

(2008) Susan E. Cellitti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

Genetically encoding Nε-acetyllysine in recombinant proteins

(2008) Heinz Neumann et al.   Nature Chemical Biology

E-clonal antibodies: selection of full-length IgG antibodies using bacterial periplasmic display

(2008) Yariv Mazor et al.   Nature Protocols

Protein evolution with an expanded genetic code

(2008) C. C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

(2007) Ravi V. J. Chari   ACCOUNTS OF CHEMICAL RESEARCH

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY