The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins

(2015) Daria Zdżalik et al.   DNA REPAIR

DecreasedN6-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated WithFTOExpression Rather ThanALKBH5

(2015) Fan Shen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Next-generation sequencing reveals the biological significance of the N2,3-ethenoguanine lesion in vivo

(2015) S.-c. Chang et al.   NUCLEIC ACIDS RESEARCH

Switching Demethylation Activities between AlkB Family RNA/DNA Demethylases through Exchange of Active-Site Residues

(2014) Chenxu Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation

(2014) Li Shen et al.   Annual Review of Biochemistry

Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease

(2014) U. Chandola et al.   Briefings in Functional Genomics

Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB

(2014) Vipender Singh et al.   CHEMICAL RESEARCH IN TOXICOLOGY

FTO and Obesity: Mechanisms of Association

(2014) Xu Zhao et al.   Current Diabetes Reports

DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: An emerging complex story

(2014) Peter W.S. Hill et al.   GENOMICS

The Atomic Resolution Structure of Human AlkB Homolog 7 (ALKBH7), a Key Protein for Programmed Necrosis and Fat Metabolism

(2014) Guoqiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-strandedN6-Methyladenosine RNA Demethylation

(2014) Chao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition

(2014) Chong Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Pathway for the Reaction Catalyzed by DNA Dealkylase AlkB from Ab Initio QM/MM Calculations

(2014) Dong Fang et al.   Journal of Chemical Theory and Computation

Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1)

(2014) Pavel Silvestrov et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Theory Uncovers an Unusual Mechanism of DNA Repair of a Lesioned Adenine by AlkB Enzymes

(2014) Binju Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Chemical Genetics Analysis of the Roles of Bypass Polymerase DinB and DNA Repair Protein AlkB in Processing N2-Alkylguanine Lesions In Vivo

(2014) Nidhi Shrivastav et al.   PLoS One

Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities

(2014) Daria Zdżalik et al.   PLoS One

L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

(2014) E.-H. Shim et al.   Cancer Discovery

A covalent protein–DNA 5′-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1)

(2013) Tina A. Müller et al.   BIOCHEMICAL JOURNAL

Removal of N-Alkyl Modifications from N2-Alkylguanine and N4-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

(2013) Deyu Li et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis

(2013) D. Fu et al.   GENES & DEVELOPMENT

ALKBH1 Is Dispensable for Abasic Site Cleavage during Base Excision Repair and Class Switch Recombination

(2013) Tina A. Müller et al.   PLoS One

FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis

(2013) Chibo Liu et al.   PLoS One

Deletion of mouse Alkbh7 leads to obesity

(2013) A. Solberg et al.   Journal of Molecular Cell Biology

DNA Repair by Reversal of DNA Damage

(2013) C. Yi et al.   Cold Spring Harbor Perspectives in Biology

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics

(2013) Ming-Ming Li et al.   Nature Communications

ABH2 Couples Regulation of Ribosomal DNA Transcription with DNA Alkylation Repair

(2013) Pishun Li et al.   Cell Reports

Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells

(2012) K. Koike et al.   CURRENT CANCER DRUG TARGETS

Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts

(2012) Stephanie L. Nay et al.   DNA REPAIR

The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity

(2012) Hanne Korvald et al.   DNA REPAIR

AlkB Dioxygenase Preferentially Repairs Protonated Substrates

(2012) Agnieszka M. Maciejewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA repair is indispensable for survival after acute inflammation

(2012) Jennifer A. Calvo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic Studies on the Application of DNA Aptamers as Inhibitors of 2-Oxoglutarate-Dependent Oxygenases

(2012) Svetlana M. Krylova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

(2012) Esther C. Y. Woon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exocyclic Carbons Adjacent to the N6 of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB

(2012) Deyu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

ALKBH1 is a Histone H2A Dioxygenase Involved in Neural Differentiation

(2012) Rune Ougland et al.   STEM CELLS

Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4

(2011) Linn G. Bjørnstad et al.   BIOCHEMICAL JOURNAL

Direct repair of 3,N4-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase

(2011) Dragony Fu et al.   DNA REPAIR

Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification

(2011) Chiara Pastore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation

(2011) Sebastian Dango et al.   MOLECULAR CELL

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)

(2011) Armin Thalhammer et al.   PLoS One

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

(2011) Erwin van den Born et al.   Nature Communications

The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5-Methoxycarbonylmethyluridine at the Wobble Position of tRNA

(2010) Ye Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Frequent down-regulation of hABH2 in gastric cancer and its involvement in growth of cancer cells

(2010) Wei Gao et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

(2010) D. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanistic insight into the recognition of single-stranded and double-stranded DNA substrates by ABH2 and ABH3

(2010) Baoen Chen et al.   Molecular BioSystems

Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase

(2010) Chengqi Yi et al.   NATURE

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Mice Lacking Alkbh1 Display Sex-Ratio Distortion and Unilateral Eye Defects

(2010) Line M. Nordstrand et al.   PLoS One

DFT study of a model system for the dealkylation step catalyzed by AlkB

(2010) G. Andrés Cisneros   Interdisciplinary Sciences-Computational Life Sciences

Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation

(2009) N. Shrivastav et al.   CARCINOGENESIS

Pediatric brain tumors: mutations of two dioxygenases (hABH2 and hABH3) that directly repair alkylation damage

(2009) Valentina Cetica et al.   JOURNAL OF NEURO-ONCOLOGY

A DFT Study of Nucleobase Dealkylation by the DNA Repair Enzyme AlkB

(2009) Haining Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Chloroacetaldehyde-induced mutagenesis in Escherichia coli: The role of AlkB protein in repair of 3,N4-ethenocytosine and 3,N4-α-hydroxyethanocytosine

(2009) Agnieszka M. Maciejewska et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria

(2009) Erwin van den Born et al.   NUCLEIC ACIDS RESEARCH

Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB

(2009) B. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in Chemical Carcinogenesis: A Historical Review and Prospective

(2008) L. A. Loeb et al.   CANCER RESEARCH

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

(2008) Guifang Jia et al.   FEBS LETTERS

Human AlkB Homolog 1 Is a Mitochondrial Protein That Demethylates 3-Methylcytosine in DNA and RNA

(2008) Marianne Pedersen Westbye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

(2008) Cai-Guang Yang et al.   NATURE

Viral AlkB proteins repair RNA damage by oxidative demethylation

(2008) Erwin van den Born et al.   NUCLEIC ACIDS RESEARCH