The N-End Rule Pathway

Expression and Biochemical Characterization of the Human Enzyme N-Terminal Asparagine Amidohydrolase

(2011) Jason R. Cantor et al.   BIOCHEMISTRY

Arginyltransferase Is an ATP-Independent Self-Regulating Enzyme that Forms Distinct Functional Complexes In Vivo

(2011) Junling Wang et al.   CHEMISTRY & BIOLOGY

Posttranslational arginylation as a global biological regulator

(2011) Sougata Saha et al.   DEVELOPMENTAL BIOLOGY

EDD Inhibits ATM-mediated Phosphorylation of p53

(2011) Shiyun Ling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission

(2011) Juan A. Bernal et al.   JOURNAL OF CELL BIOLOGY

The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease

(2011) Giselle Román-Hernández et al.   MOLECULAR CELL

Alternative Ubiquitin Activation/Conjugation Cascades Interact with N-End Rule Ubiquitin Ligases to Control Degradation of RGS Proteins

(2011) Peter C.W. Lee et al.   MOLECULAR CELL

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization

(2011) Francesco Licausi et al.   NATURE

Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants

(2011) Daniel J. Gibbs et al.   NATURE

The N-end rule pathway: emerging functions and molecular principles of substrate recognition

(2011) Shashikanth M. Sriram et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

(2011) Cornelia Meisenberg et al.   NUCLEIC ACIDS RESEARCH

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

The arginylation-dependent association of calreticulin with stress granules is regulated by calcium

(2010) Marcos A. Carpio et al.   BIOCHEMICAL JOURNAL

Novel UBR1 gene mutation in a patient with typical phenotype of Johanson–Blizzard syndrome

(2010) Gholam Hossein Fallahi et al.   EUROPEAN JOURNAL OF PEDIATRICS

Eponym

(2010) Nima Rezaei et al.   EUROPEAN JOURNAL OF PEDIATRICS

Hemin Binds to Human Cytoplasmic Arginyl-tRNA Synthetase and Inhibits Its Catalytic Activity

(2010) Fang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factor IIS Cooperates with the E3 Ligase UBR5 to Ubiquitinate the CDK9 Subunit of the Positive Transcription Elongation Factor B

(2010) Marilena Cojocaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unraveling the genetics of otitis media: from mouse to human and back again

(2010) Marie S. Rye et al.   MAMMALIAN GENOME

The bacterial N-end rule pathway: expect the unexpected

(2010) D. A. Dougan et al.   MOLECULAR MICROBIOLOGY

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases

(2010) Woo Suk Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of substrate recognition and specificity in the N-end rule pathway

(2010) Edna Matta-Camacho et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular principles of N-end rule recognition

(2010) Shashikanth M Sriram et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of protein stability determinants in chloroplasts

(2010) Wiebke Apel et al.   PLANT JOURNAL

UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

(2010) J. Y. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Local and Global Mobility in the ClpA AAA+ Chaperone Detected by Cryo-Electron Microscopy: Functional Connotations

(2010) Grégory Effantin et al.   STRUCTURE

The plant N-end rule pathway: structure and functions

(2010) Emmanuelle Graciet et al.   TRENDS IN PLANT SCIENCE

Arginylation-Dependent Neural Crest Cell Migration Is Essential for Mouse Development

(2010) Satoshi Kurosaka et al.   PLoS Genetics

Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death

(2009) Mariam Orme et al.   APOPTOSIS

Amino-acid-induced signalling via the SPS-sensing pathway in yeast

(2009) Per O. Ljungdahl   BIOCHEMICAL SOCIETY TRANSACTIONS

Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin- Dependent N-End Rule Pathway

(2009) Shashikanth M. Sriram et al.   CHEMISTRY & BIOLOGY

Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli

(2009) Robert L Ninnis et al.   EMBO JOURNAL

Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS

(2009) Verena J Schuenemann et al.   EMBO REPORTS

The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing

(2009) Young Eun Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway

(2009) Haiqing Wang et al.   MOLECULAR CELL

ClpS is the recognition component forEscherichia colisubstrates of the N-end rule degradation pathway

(2009) Ronny Schmidt et al.   MOLECULAR MICROBIOLOGY

Efficient protein depletion by genetically controlled deprotection of a dormant N-degron

(2009) Christof Taxis et al.   Molecular Systems Biology

Ablation of Arginylation in the Mouse N-End Rule Pathway: Loss of Fat, Higher Metabolic Rate, Damaged Spermatogenesis, and Neurological Perturbations

(2009) Christopher S. Brower et al.   PLoS One

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

(2009) C.-S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development

(2009) E. Graciet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1

(2008) Frederik Eisele et al.   FEBS LETTERS

The Substrate Recognition Domains of the N-end Rule Pathway

(2008) Takafumi Tasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway

(2008) Zanxian Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acids Induce Peptide Uptake via Accelerated Degradation of CUP9, the Transcriptional Repressor of the PTR2 Peptide Transporter

(2008) Zanxian Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein 600 Is a Microtubule/Endoplasmic Reticulum-Associated Protein in CNS Neurons

(2008) S. Y. Shim et al.   JOURNAL OF NEUROSCIENCE

The Molecular Basis of N-End Rule Recognition

(2008) Kevin H. Wang et al.   MOLECULAR CELL

Inactivation of Effector Caspases through Nondegradative Polyubiquitylation

(2008) Mark Ditzel et al.   MOLECULAR CELL

Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway

(2008) C.-S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA