Modifications and functional genomics of human transfer RNA

Hili Inhibits HIV Replication in Activated T Cells

(2017) B. Matija Peterlin et al.   JOURNAL OF VIROLOGY

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

(2017) Paul Schimmel   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Determination of tRNA aminoacylation levels by high-throughput sequencing

(2017) Molly E. Evans et al.   NUCLEIC ACIDS RESEARCH

ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications

(2017) Layla Kawarada et al.   NUCLEIC ACIDS RESEARCH

The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing

(2017) Ed Lein et al.   SCIENCE

Single-cell transcriptomics to explore the immune system in health and disease

(2017) Michael J. T. Stubbington et al.   SCIENCE

Lost in Translation: Defects in Transfer RNA Modifications and Neurological Disorders

(2017) Andrea Bednářová et al.   Frontiers in Molecular Neuroscience

ALKBH1-Mediated tRNA Demethylation Regulates Translation

(2016) Fange Liu et al.   CELL

Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression

(2016) Hani Goodarzi et al.   CELL

A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition

(2016) Ranad Shaheen et al.   HUMAN GENETICS

tRNA base methylation identification and quantification via high-throughput sequencing

(2016) Wesley C. Clark et al.   RNA

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

(2016) Pankaj Kumar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

(2016) Ryuta Ishimura et al.   eLife

TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies

(2015) Christopher A. Powell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

(2015) Danny D. Nedialkova et al.   CELL

Defects in tRNA Anticodon Loop 2′-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations inFTSJ1

(2015) Michael P. Guy et al.   HUMAN MUTATION

Efficient and quantitative high-throughput tRNA sequencing

(2015) Guanqun Zheng et al.   NATURE METHODS

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes

(2015) Patricia P. Chan et al.   NUCLEIC ACIDS RESEARCH

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

(2015) Shozo Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification

(2015) Aneeshkumar G. Arimbasseri et al.   PLoS Genetics

Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease

(2015) Christopher A. Powell et al.   Frontiers in Genetics

GCN2, an old dog with new tricks

(2015) Beáta Grallert et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Keeping the eIF2 alpha kinase Gcn2 in check

(2014) Beatriz A. Castilho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

(2014) Hila Gingold et al.   CELL

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

tRNA modifications regulate translation during cellular stress

(2014) Chen Gu et al.   FEBS LETTERS

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface

(2014) Bianca M. Schmitt et al.   GENOME RESEARCH

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease

(2014) Sebastian Kirchner et al.   NATURE REVIEWS GENETICS

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs

(2014) T. Suzuki et al.   NUCLEIC ACIDS RESEARCH

Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5

(2014) G. E. Katibah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity of human tRNA genes from the 1000-genomes project

(2014) Marc Parisien et al.   RNA Biology

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Transfer RNA and human disease

(2014) Jamie A. Abbott et al.   Frontiers in Genetics

A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α

(2013) Ulrike Begley et al.   EMBO Molecular Medicine

tRNA Binding, Structure, and Localization of the Human Interferon-Induced Protein IFIT5

(2013) George E. Katibah et al.   MOLECULAR CELL

Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate

(2013) Zhenhua Shao et al.   NUCLEIC ACIDS RESEARCH

The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL

(2013) Ru-Juan Liu et al.   NUCLEIC ACIDS RESEARCH

Environmental perturbations lift the degeneracy of the genetic code to regulate protein levels in bacteria

(2013) A. R. Subramaniam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

(2013) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermostable group II intron reverse transcriptase fusion proteins and their use in cDNA synthesis and next-generation RNA sequencing

(2013) S. Mohr et al.   RNA

HAMR: high-throughput annotation of modified ribonucleotides

(2013) P. Ryvkin et al.   RNA

Discovering RNA-Protein Interactome by Using Chemical Context Profiling of the RNA-Protein Interface

(2013) Marc Parisien et al.   Cell Reports

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

(2013) Mariana Igoillo-Esteve et al.   PLoS Genetics

A Role for tRNA Modifications in Genome Structure and Codon Usage

(2012) Eva Maria Novoa et al.   CELL

Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

(2012) Manqing Li et al.   NATURE

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs

(2012) T. Chujo et al.   RNA

Human Mitochondrial tRNAs: Biogenesis, Function, Structural Aspects, and Diseases

(2011) Tsutomu Suzuki et al.   Annual Review of Genetics

The Human Mitochondrial Transcriptome

(2011) Tim R. Mercer et al.   CELL

Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice

(2011) Fan-Yan Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes

(2011) Claudia Kutter et al.   NATURE GENETICS

Misfolded human tRNA isodecoder binds and neutralizes a 3' UTR-embedded Alu element

(2011) J. Rudinger-Thirion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5-Methoxycarbonylmethyluridine at the Wobble Position of tRNA

(2010) Ye Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding

(2010) L. Songe-Moller et al.   MOLECULAR AND CELLULAR BIOLOGY

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

(2010) D. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

tRNA Binds to Cytochrome c and Inhibits Caspase Activation

(2010) Yide Mei et al.   MOLECULAR CELL

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p

(2009) John M. Zaborske et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Functional Analysis of Human tRNA Isodecoders

(2009) Renaud Geslain et al.   JOURNAL OF MOLECULAR BIOLOGY

tRNA over-expression in breast cancer and functional consequences

(2009) Mariana Pavon-Eternod et al.   NUCLEIC ACIDS RESEARCH

Meta-analysis of small RNA-sequencing errors reveals ubiquitous post-transcriptional RNA modifications

(2009) H. Alexander Ebhardt et al.   NUCLEIC ACIDS RESEARCH