tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

(2018) Nicola Guzzi et al.   CELL

5′-tRNA Halves are Dysregulated in Clear Cell Renal Cell Carcinoma

(2018) Chenming Zhao et al.   JOURNAL OF UROLOGY

Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response

(2018) Shiqi Luo et al.   NUCLEIC ACIDS RESEARCH

Profiles of miRNA Isoforms and tRNA Fragments in Prostate Cancer

(2018) Rogan G. Magee et al.   Scientific Reports

Identification of two novel functional tRNA-derived fragments induced in response to respiratory syncytial virus infection

(2017) Jiehua Zhou et al.   JOURNAL OF GENERAL VIROLOGY

Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs

(2017) Siqi Li et al.   MOLECULAR NEUROBIOLOGY

A transfer-RNA-derived small RNA regulates ribosome biogenesis

(2017) Hak Kyun Kim et al.   NATURE

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

(2017) Paul Schimmel   NATURE REVIEWS MOLECULAR CELL BIOLOGY

tRNA-derived small RNAs target transposable element transcripts

(2017) German Martinez et al.   NUCLEIC ACIDS RESEARCH

Total Extracellular Small RNA Profiles from Plasma, Saliva and Urine of Healthy Subjects

(2017) Ashish Yeri et al.   Scientific Reports

Differentially Expressed tRNA-Derived Small RNAs Co-Sediment Primarily with Non-Polysomal Fractions in Drosophila

(2017) Çağdaş Göktaş et al.   Genes

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

(2016) Ida Donkin et al.   Cell Metabolism

IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells

(2016) Xue Zhang et al.   JOURNAL OF IMMUNOLOGY

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

(2016) Peter Huypens et al.   NATURE GENETICS

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

(2016) Shawn M. Lyons et al.   NUCLEIC ACIDS RESEARCH

tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers

(2016) Ling-Ling Zheng et al.   NUCLEIC ACIDS RESEARCH

Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer

(2016) Yuri Pekarsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A tRNA-derived fragment competes with mRNA for ribosome binding and regulates translation during stress

(2016) Jennifer Gebetsberger et al.   RNA Biology

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

(2016) Thais de Castro Barbosa et al.   Molecular Metabolism

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

Profiling of small RNA cargo of extracellular vesicles shed by Trypanosoma cruzi reveals a specific extracellular signature

(2015) Tamara Fernandez-Calero et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism

(2015) Junfang Deng et al.   MOLECULAR THERAPY

TCL1targetingmiR-3676is codeleted with tumor protein p53 in chronic lymphocytic leukemia

(2015) Veronica Balatti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

(2015) Shozo Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

5′ tRNA Halves: The Next Generation of Immune Signaling Molecules

(2015) Joseph Mohsen Dhahbi   Frontiers in Immunology

Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets

(2014) Pankaj Kumar et al.   BMC BIOLOGY

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage

(2014) E. Mishima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Small Noncoding RNAs in Cells Transformed by Human T-Cell Leukemia Virus Type 1: a Role for a tRNA Fragment as a Primer for Reverse Transcriptase

(2014) K. Ruggero et al.   JOURNAL OF VIROLOGY

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease

(2014) Sebastian Kirchner et al.   NATURE REVIEWS GENETICS

tRFdb: a database for transfer RNA fragments

(2014) Pankaj Kumar et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection

(2014) Yunfang Zhang et al.   Journal of Molecular Cell Biology

Methylated nucleosides in tRNA and tRNA methyltransferases

(2014) Hiroyuki Hori   Frontiers in Genetics

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

(2013) Joseph M Dhahbi et al.   BMC GENOMICS

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

(2013) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

(2013) Andrew Sobala et al.   RNA Biology

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

(2013) Shobbir Hussain et al.   Cell Reports

Biosynthesis and Function of Posttranscriptional Modifications of Transfer RNAs

(2012) Basma El Yacoubi et al.   Annual Review of Genetics

A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm

(2012) Hongying Peng et al.   CELL RESEARCH

Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress

(2012) Mridusmita Saikia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct subcellular localization of tRNA-derived fragments in the infective metacyclic forms of Trypanosoma cruzi

(2012) Larissa Reifur et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

A Tetrahymena Piwi Bound to Mature tRNA 3′ Fragments Activates the Exonuclease Xrn2 for RNA Processing in the Nucleus

(2012) Mary T. Couvillion et al.   MOLECULAR CELL

Identification and Functional Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection

(2012) Qingrong Wang et al.   MOLECULAR THERAPY

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs

(2012) Zhihua Li et al.   NUCLEIC ACIDS RESEARCH

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

microRNAs associated with the different human Argonaute proteins

(2012) A. Dueck et al.   NUCLEIC ACIDS RESEARCH

tRNA-Derived Fragments Target the Ribosome and Function as Regulatory Non-Coding RNA inHaloferax volcanii

(2012) Jennifer Gebetsberger et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles

(2011) J. Wang et al.   GENOME RESEARCH

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

A miRNA-tRNA mix-up: tRNA origin of proposed miRNA

(2011) Nick C.T. Schopman et al.   RNA Biology

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

A population of tRNA-derived small RNAs is actively produced in Trypanosoma cruzi and recruited to specific cytoplasmic granules

(2010) Maria Rosa Garcia-Silva et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

tRNA Binds to Cytochrome c and Inhibits Caspase Activation

(2010) Yide Mei et al.   MOLECULAR CELL

Deep Sequencing of Human Nuclear and Cytoplasmic Small RNAs Reveals an Unexpectedly Complex Subcellular Distribution of miRNAs and tRNA 3′ Trailers

(2010) Jian-You Liao et al.   PLoS One

Human tRNA-derived small RNAs in the global regulation of RNA silencing

(2010) D. Haussecker et al.   RNA

3′ processing of eukaryotic precursor tRNAs

(2010) Richard J. Maraia et al.   Wiley Interdisciplinary Reviews-RNA

tRNAs: Cellular barcodes for amino acids

(2009) Rajat Banerjee et al.   FEBS LETTERS

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress inSaccharomyces cerevisiae

(2009) Debrah M. Thompson et al.   JOURNAL OF CELL BIOLOGY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Uncovering Small RNA-Mediated Responses to Phosphate Deficiency in Arabidopsis by Deep Sequencing

(2009) L.-C. Hsieh et al.   PLANT PHYSIOLOGY

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

(2009) C. Cole et al.   RNA

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

Stress-induced tRNA-derived RNAs: a novel class of small RNAs in the primitive eukaryote Giardia lamblia

(2008) Yan Li et al.   NUCLEIC ACIDS RESEARCH

Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis

(2008) Christoph Jöchl et al.   NUCLEIC ACIDS RESEARCH

tRNA cleavage is a conserved response to oxidative stress in eukaryotes

(2008) D. M. Thompson et al.   RNA