How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

Interdependence of Gemcitabine Treatment, Transporter Expression, and Resistance in Human Pancreatic Carcinoma Cells

(2015) Wolfgang Hagmann et al.   NEOPLASIA

Quantitative Targeted Proteomics for Membrane Transporter Proteins: Method and Application

(2014) Xi Qiu et al.   AAPS Journal

Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions

(2014) Munir Pirmohamed   Annual Review of Genomics and Human Genetics

Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach

(2014) N Tsamandouras et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update

(2014) L B Ramsey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review

(2014) V. L. M. Yip et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Beyond the ITC White Paper: Emerging Sciences in Drug Transporters and Opportunities for Drug Development

(2014) Yurong Lai et al.   CURRENT PHARMACEUTICAL DESIGN

Stereoselectivity of chiral drug transport: a focus on enantiomer–transporter interaction

(2014) Quan Zhou et al.   DRUG METABOLISM REVIEWS

Drug delivery: A process governed by species-specific lipophilicities

(2014) Károly Mazák et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vitroandin vivoapproaches to characterize transporter-mediated disposition in drug discovery

(2014) Bo Feng et al.   Expert Opinion on Drug Discovery

Ligand efficiency metrics considered harmful

(2014) Peter W. Kenny et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

MALDI imaging mass spectrometry: Spatial molecular analysis to enable a new age of discovery

(2014) Megan M. Gessel et al.   Journal of Proteomics

Identification of a novel ATP-binding cassette transporter involved in long-chain fatty acid import and its role in triacylglycerol accumulation in Rhodococcus jostii RHA1

(2014) M. S. Villalba et al.   MICROBIOLOGY-SGM

The Low/High BCS Permeability Class Boundary: Physicochemical Comparison of Metoprolol and Labetalol

(2014) Moran Zur et al.   MOLECULAR PHARMACEUTICS

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

(2014) Dennis Smith et al.   MOLECULAR PHARMACEUTICS

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

(2014) Georg E Winter et al.   Nature Chemical Biology

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

PharmGKB summary

(2014) Srijib Goswami et al.   Pharmacogenetics and Genomics

Trends in QconCATs for targeted proteomics

(2014) Junjun Chen et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

hENT1 expression is predictive of gemcitabine outcome in pancreatic cancer: A systematic review

(2014) Stina Nordh   WORLD JOURNAL OF GASTROENTEROLOGY

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

(2014) Smriti Mishra et al.   eLife

Understanding and preventing drug–drug and drug–gene interactions

(2014) Cara Tannenbaum et al.   Expert Review of Clinical Pharmacology

Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy

(2013) Samir F. El-Mashtoly et al.   ANALYST

SATP (YaaH), a succinate–acetate transporter protein inEscherichia coli

(2013) Joana Sá-Pessoa et al.   BIOCHEMICAL JOURNAL

Visualizing Functional Motions of Membrane Transporters with Molecular Dynamics Simulations

(2013) Saher A. Shaikh et al.   BIOCHEMISTRY

Aquaporins and membrane diffusion of CO2 in living organisms

(2013) Ralf Kaldenhoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Plant aquaporins: Roles in plant physiology

(2013) Guowei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Fatty acid transporters in skin development, function and disease

(2013) Meei-Hua Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Do hENT1 and RRM1 predict the clinical benefit of gemcitabine in pancreatic cancer?

(2013) Lars Petter Jordheim et al.   Biomarkers in Medicine

Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia

(2013) Benjamin D. Stevens et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects

(2013) Shaoyi Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance

(2013) Hua Ling et al.   Biotechnology for Biofuels

Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae

(2013) Binbin Chen et al.   Biotechnology for Biofuels

Directed evolution of an E. coli inner membrane transporter for improved efflux of biofuel molecules

(2013) Jee Foo et al.   Biotechnology for Biofuels

DMET™ (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity

(2013) Enrica Rumiato et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Flexibility and Reactivity in Promiscuous Enzymes

(2013) Pietro Gatti-Lafranconi et al.   CHEMBIOCHEM

Influence of lipids on protein-mediated transmembrane transport

(2013) Elizabeth J. Denning et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Stereoselective Accumulation of Propranolol Enantiomers in K562 and K562/ADR Cells

(2013) Xiao-Li Zheng et al.   CHIRALITY

Erlotinib, Gefitinib, and Vandetanib Inhibit Human Nucleoside Transporters and Protect Cancer Cells from Gemcitabine Cytotoxicity

(2013) V. L. Damaraju et al.   CLINICAL CANCER RESEARCH

Transporters in Drug Development and Clinical Pharmacology

(2013) K M Giacomini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

(2013) X Chu et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

SLC Classification: An Update

(2013) A Schlessinger et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

(2013) K L R Brouwer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms

(2013) K M Giacomini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport-Mediated PK and DDIs in Humans

(2013) M J Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink

(2013) D F Carr et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

OATP transporter-mediated drug absorption and interaction

(2013) Ikumi Tamai et al.   CURRENT OPINION IN PHARMACOLOGY

Drug Discovery Applications for KNIME: An Open Source Data Mining Platform

(2013) Michael P. Mazanetz et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Medicinal Chemistry Design Principles for Liver Targeting Through OATP Transporters

(2013) Meihua Tu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Intestinal Targeting of Drugs: Rational Design Approaches and Challenges

(2013) Kevin J. Filipski et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular Modeling and Ligand Docking for Solute Carrier (SLC) Transporters

(2013) Avner Schlessinger et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery

(2013) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Genetic polymorphisms of SLC28A3, SLC29A1 and RRM1 predict clinical outcome in patients with metastatic breast cancer receiving gemcitabine plus paclitaxel chemotherapy

(2013) Soo-Youn Lee et al.   EUROPEAN JOURNAL OF CANCER

Towards a unified model of passive drug permeation I: Origins of the unstirred water layer with applications to ionic permeation

(2013) Avijit Ghosh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Animal versus human oral drug bioavailability: Do they correlate?

(2013) Helen Musther et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Oral biopharmaceutics tools – Time for a new initiative – An introduction to the IMI project OrBiTo

(2013) H. Lennernäs et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Strategies for the design of hepatoselective glucokinase activators to treat type 2 diabetes

(2013) Jeffrey A Pfefferkorn   Expert Opinion on Drug Discovery

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it

(2013) Douglas B. Kell   FEBS Journal

ABC transporters and cell wall proteins involved in organic solvent tolerance in Saccharomyces cerevisiae

(2013) Nao Nishida et al.   JOURNAL OF BIOTECHNOLOGY

BioSM: Metabolomics Tool for Identifying Endogenous Mammalian Biochemical Structures in Chemical Structure Space

(2013) Mai A. Hamdalla et al.   Journal of Chemical Information and Modeling

Systems approaches and polypharmacology for drug discovery from herbal medicines: An example using licorice

(2013) Hui Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Molecular Similarity in Medicinal Chemistry

(2013) Gerald Maggiora et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polypharmacology – Foe or Friend?

(2013) Jens-Uwe Peters   JOURNAL OF MEDICINAL CHEMISTRY

The pre-synaptic Munc13-1 binds alcohol and modulates alcohol self-administration inDrosophila

(2013) Joydip Das et al.   JOURNAL OF NEUROCHEMISTRY

Propranolol Transport Across the Inner Blood–Retinal Barrier: Potential Involvement of a Novel Organic Cation Transporter

(2013) Yoshiyuki Kubo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Alternative Fusion Protein Strategies to Express Recalcitrant QconCAT Proteins for Quantitative Proteomics of Human Drug Metabolizing Enzymes and Transporters

(2013) Matthew R. Russell et al.   JOURNAL OF PROTEOME RESEARCH

An analysis of a ‘community-driven’ reconstruction of the human metabolic network

(2013) Neil Swainston et al.   Metabolomics

Roles of the nucleotide sugar transporters (SLC35 family) in health and disease

(2013) Zhiwei Song   MOLECULAR ASPECTS OF MEDICINE

The SLCO (former SLC21) superfamily of transporters

(2013) Bruno Hagenbuch et al.   MOLECULAR ASPECTS OF MEDICINE

Transporter biology in drug approval: Regulatory aspects

(2013) Kazuya Maeda et al.   MOLECULAR ASPECTS OF MEDICINE

The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29

(2013) James D. Young et al.   MOLECULAR ASPECTS OF MEDICINE

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

Yeast cells with impaired drug resistance accumulate glycerol and glucose

(2013) Duygu Dikicioglu et al.   Molecular BioSystems

Quantitative Prediction of Renal Transporter-Mediated Clinical Drug–Drug Interactions

(2013) Bo Feng et al.   MOLECULAR PHARMACEUTICS

Comparison of the Permeability of Metoprolol and Labetalol in Rat, Mouse, and Caco-2 Cells: Use as a Reference Standard for BCS Classification

(2013) Tuba Incecayir et al.   MOLECULAR PHARMACEUTICS

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

A reversible gene trap collection empowers haploid genetics in human cells

(2013) Tilmann Bürckstümmer et al.   NATURE METHODS

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3

(2013) Britta Haenisch et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Systems pharmacology meets predictive, preventive, personalized and participatory medicine

(2013) Sherry L Jenkins et al.   PHARMACOGENOMICS

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

(2013) Peter Csermely et al.   PHARMACOLOGY & THERAPEUTICS

Ligand Induced Conformational Changes of the Human Serotonin Transporter Revealed by Molecular Dynamics Simulations

(2013) Heidi Koldsø et al.   PLoS One

Water access points and hydration pathways in CLC H+/Cl−transporters

(2013) Wei Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transporter-mediated biofuel secretion

(2013) R. Doshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of lipid-pore loop interface for potassium channel structure and function

(2013) E. A. W. van der Cruijsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic picture for conformational transition of a membrane transporter at atomic resolution

(2013) M. Moradi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic-level description of ubiquitin folding

(2013) S. Piana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol as a co-solvent and a ligand for membrane proteins

(2013) Yuanli Song et al.   PROTEIN SCIENCE

Multiscale Simulations Reveal Conserved Patterns of Lipid Interactions with Aquaporins

(2013) Phillip J. Stansfeld et al.   STRUCTURE

Detection of Statin Cytotoxicity Is Increased in Cells Expressing the OATP1B1 Transporter

(2013) Xun Zhang et al.   TOXICOLOGICAL SCIENCES

What makes a P450 tick?

(2013) Andrew W. Munro et al.   TRENDS IN BIOCHEMICAL SCIENCES

Substrate promiscuity of cytochrome P450 RhF

(2013) Elaine O'Reilly et al.   Catalysis Science & Technology

Drug-grapefruit juice interactions

(2013) M. Pirmohamed   BMJ-British Medical Journal

Pharmacogenomics of adverse drug reactions

(2013) Ann K Daly   Genome Medicine

Reduced Lateral Mobility of Lipids and Proteins in Crowded Membranes

(2013) Joseph E. Goose et al.   PLoS Computational Biology

Predicting drug–drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach

(2013) Karen Rowland Yeo et al.   Expert Review of Clinical Pharmacology

Pancreatic cancer – cost for overtreatment with gemcitabine

(2012) Daniel Ansari et al.   ACTA ONCOLOGICA

Intestinal drug transporters: An overview

(2012) Margarida Estudante et al.   ADVANCED DRUG DELIVERY REVIEWS

Evaluation of an Accurate Mass Approach for the Simultaneous Detection of Drug and Metabolite Distributions via Whole-Body Mass Spectrometric Imaging

(2012) Sheerin K. Shahidi-Latham et al.   ANALYTICAL CHEMISTRY

Biomolecular Simulation: A Computational Microscope for Molecular Biology

(2012) Ron O. Dror et al.   Annual Review of Biophysics

Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetic Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms

(2012) Kenta Yoshida et al.   Annual Review of Pharmacology and Toxicology

Systems Pharmacology to Predict Drug Toxicity: Integration Across Levels of Biological Organization

(2012) Jane P.F. Bai et al.   Annual Review of Pharmacology and Toxicology

The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1

(2012) Ali R. Saadatmand et al.   BIOCHEMICAL PHARMACOLOGY

Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments?

(2012) Douglas B. Kell   BIOESSAYS

Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanisticin vitro-in vivoextrapolation of oral drug absorption

(2012) M. D. Harwood et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

(2012) Yoshihisa Shitara et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

(2012) Karin Lanthaler et al.   BMC BIOLOGY

Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs

(2012) Laia Trigueros-Motos et al.   BMC CANCER

Advancing Pharmacometrics and Systems Pharmacology

(2012) S A Waldman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Drug Trafficking: Recent Advances in Therapeutics and Disease

(2012) J A Sprowl et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Transporter-Mediated Drug–Drug Interactions Involving OATP Substrates: Predictions Based on In Vitro Inhibition Studies

(2012) K Yoshida et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Understanding the Critical Disposition Pathways of Statins to Assess Drug–Drug Interaction Risk During Drug Development: It's Not Just About OATP1B1

(2012) R Elsby et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Prediction of Transporter-Mediated Drug–Drug Interactions Using Endogenous Compounds

(2012) M F Fromm   CLINICAL PHARMACOLOGY & THERAPEUTICS

The UCSF-FDA TransPortal: A Public Drug Transporter Database

(2012) K M Morrissey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy

(2012) R A Wilke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Gemcitabine: A Critical Nucleoside for Cancer Therapy

(2012) D. S. Gesto et al.   CURRENT MEDICINAL CHEMISTRY

Induced changes in protein receptors conferring resistance to anesthetics

(2012) Edward J. Bertaccini et al.   Current Opinion in Anesthesiology

Pharmacogenetic Biomarkers as Tools for Pharmacoepidemiology of Severe Adverse Drug Reactions

(2012) Karmen Stankov et al.   DRUG DEVELOPMENT RESEARCH

Relevance of systems pharmacology in drug discovery

(2012) Lourdes Cucurull-Sanchez et al.   DRUG DISCOVERY TODAY

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so

(2012) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Contribution of tumoral and host solute carriers to clinical drug response

(2012) Jason A. Sprowl et al.   DRUG RESISTANCE UPDATES

Prediction of the in vivo OATP1B1-mediated drug–drug interaction potential of an investigational drug against a range of statins

(2012) Pradeep Sharma et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Going further than Lipinski's rule in drug design

(2012) W Patrick Walters   Expert Opinion on Drug Discovery

Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs

(2012) Anne T Nies et al.   Expert Opinion on Drug Metabolism & Toxicology

Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions

(2012) John D Clarke et al.   Expert Opinion on Drug Metabolism & Toxicology

Renal drug–drug interactions: what we have learned and where we are going

(2012) Eve-Irene Lepist et al.   Expert Opinion on Drug Metabolism & Toxicology

Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability – considerations for drug development

(2012) Yurong Lai et al.   Expert Opinion on Drug Metabolism & Toxicology

Species differences in drug transporters and implications for translating preclinical findings to humans

(2012) Xiaoyan Chu et al.   Expert Opinion on Drug Metabolism & Toxicology

Anomalous and normal diffusion of proteins and lipids in crowded lipid membranes

(2012) Matti Javanainen et al.   FARADAY DISCUSSIONS

Levels of Gemcitabine Transport and Metabolism Proteins Predict Survival Times of Patients Treated With Gemcitabine for Pancreatic Adenocarcinoma

(2012) Raphaël Maréchal et al.   GASTROENTEROLOGY

Pharmacogenomics of adverse drug reactions: implementing personalized medicine

(2012) C.-Y. Wei et al.   HUMAN MOLECULAR GENETICS

Population pharmacokinetic modeling of Sepantronium bromide (YM155), a small molecule survivin suppressant, in patients with non-small cell lung cancer, hormone refractory prostate cancer, or unresectable stage III or IV melanoma

(2012) Yumiko Aoyama et al.   INVESTIGATIONAL NEW DRUGS

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Relating Molecular Properties and in Vitro Assay Results to in Vivo Drug Disposition and Toxicity Outcomes

(2012) Jeffrey J. Sutherland et al.   JOURNAL OF MEDICINAL CHEMISTRY

Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions

(2012) Maria Karlgren et al.   JOURNAL OF MEDICINAL CHEMISTRY

An in vivo role of Mrp2 in the rat hepatocytes by immunocytochemistry for amoxicillin using the transporter-deficient EHBR

(2012) Kunio Fujiwara et al.   JOURNAL OF MOLECULAR HISTOLOGY

Intestinal transporters for endogenic and pharmaceutical organic anions: the challenges of deriving in-vitro kinetic parameters for the prediction of clinically relevant drug-drug interactions

(2012) Anne Sophie Grandvuinet et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Local Lipid Reorganization by a Transmembrane Protein Domain

(2012) Heidi Koldsø et al.   Journal of Physical Chemistry Letters

Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation

(2012) Miguel C Teixeira et al.   Microbial Cell Factories

From mosaic to patchwork: Matching lipids and proteins in membrane organization

(2012) Nikola S. Mueller et al.   MOLECULAR MEMBRANE BIOLOGY

Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood–Brain Barrier Model

(2012) Sumio Ohtsuki et al.   MOLECULAR PHARMACEUTICS

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

(2012) Kivanç Birsoy et al.   NATURE GENETICS

Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)

(2012) Ivano Moschen et al.   NEUROCHEMICAL RESEARCH

Radiosynthesis, biodistribution and imaging of [11C]YM155, a novel survivin suppressant, in a human prostate tumor-xenograft mouse model

(2012) Yoshihiro Murakami et al.   NUCLEAR MEDICINE AND BIOLOGY

Role of Human Nucleoside Transporters in the Uptake and Cytotoxicity of Azacitidine and Decitabine

(2012) Vijaya L. Damaraju et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family

(2012) N Skrypek et al.   ONCOGENE

Physiologically Based Modeling of Pravastatin Transporter-Mediated Hepatobiliary Disposition and Drug-Drug Interactions

(2012) Manthena V. S. Varma et al.   PHARMACEUTICAL RESEARCH

Involvement of a Novel Organic Cation Transporter in Verapamil Transport Across the Inner Blood-Retinal Barrier

(2012) Yoshiyuki Kubo et al.   PHARMACEUTICAL RESEARCH

Role of Drug Efflux and Uptake Transporters in Atazanavir Intestinal Permeability and Drug-Drug Interactions

(2012) Olena Kis et al.   PHARMACEUTICAL RESEARCH

Frequency of adverse drug reactions in hospitalized patients: a systematic review and meta-analysis

(2012) Ana Miguel et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Pharmacogenomics of phase II metabolizing enzymes and drug transporters: clinical implications

(2012) E Ch Yiannakopoulou   PHARMACOGENOMICS JOURNAL

Adverse Drug Reactions in Children—A Systematic Review

(2012) Rebecca Mary Diane Smyth et al.   PLoS One

A Steered Molecular Dynamics Study of Binding and Translocation Processes in the GABA Transporter

(2012) Søren Skovstrup et al.   PLoS One

Refinement of protein structure homology models via long, all-atom molecular dynamics simulations

(2012) Alpan Raval et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Pharmacogenomics and Patient Care: One Size Does Not Fit All

(2012) K. M. Giacomini et al.   Science Translational Medicine

Epistemic and methodological iteration in scientific research

(2012) Kevin C. Elliott   STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE

Combined analysis of intratumoral human equilibrative nucleoside transporter 1 (hENT1) and ribonucleotide reductase regulatory subunit M1 (RRM1) expression is a powerful predictor of survival in patients with pancreatic carcinoma treated with adjuvant gemcitabine-based chemotherapy after operative resection

(2012) Naoya Nakagawa et al.   SURGERY

Mass spectrometry imaging is moving toward drug protein co-localization

(2012) Rima Ait-Belkacem et al.   TRENDS IN BIOTECHNOLOGY

On the origins of drug polypharmacology

(2012) Xavier Jalencas et al.   MedChemComm

BDDCS Applied to Over 900 Drugs

(2011) Leslie Z. Benet et al.   AAPS Journal

Alcohol-Binding Sites in Distinct Brain Proteins: The Quest for Atomic Level Resolution

(2011) Rebecca J. Howard et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Mass spectrometry imaging with high resolution in mass and space (HR2 MSI) for reliable investigation of drug compound distributions on the cellular level

(2011) Andreas Römpp et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs

(2011) Lei Xie et al.   Annual Review of Pharmacology and Toxicology

Using Genome-Wide Association Studies to Identify Genes Important in Serious Adverse Drug Reactions

(2011) Ann K. Daly   Annual Review of Pharmacology and Toxicology

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

Pharmacogenetics of Drug Metabolizing Enzymes and Transporters: Effects on Pharmacokinetics and Pharmacodynamics of Anticancer Agents

(2011) Norman H. Lee   Anti-Cancer Agents in Medicinal Chemistry

Role of transporters in drug interactions

(2011) Hyo-Kyung Han   ARCHIVES OF PHARMACAL RESEARCH

The role of membrane thickness in charged protein–lipid interactions

(2011) Libo B. Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid–protein interactions in biological membranes: A dynamic perspective

(2011) Adam W. Smith   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Transmembrane helices can induce domain formation in crowded model membranes

(2011) Jan Domański et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors

(2011) Yeeman K. Ramtohul et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

(2011) David A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series

(2011) Nicolas Lachance et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series

(2011) Nicolas Lachance et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Membrane Interface Composition Drives the Structure and the Tilt of the Single Transmembrane Helix Protein PMP1: MD Studies

(2011) Veronica Beswick et al.   BIOPHYSICAL JOURNAL

Interaction of innovative small molecule drugs used for cancer therapy with drug transporters

(2011) K Mandery et al.   BRITISH JOURNAL OF PHARMACOLOGY

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

(2011) Atsushi Yonezawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

CNT1 Expression Influences Proliferation and Chemosensitivity in Drug-Resistant Pancreatic Cancer Cells

(2011) Y. D. Bhutia et al.   CANCER RESEARCH

Cytochromes P450 as useful biocatalysts: addressing the limitations

(2011) Elaine O'Reilly et al.   CHEMICAL COMMUNICATIONS

A Decade of the Human Genome Sequence-How Does the Medicinal Chemist Benefit?

(2011) Andreas Brunschweiger et al.   ChemMedChem

Roles of organic anion/cation transporters at the blood–brain and blood–cerebrospinal fluid barriers involving uremic toxins

(2011) Ken-ichi Hosoya et al.   Clinical and Experimental Nephrology

A New Trend in Personalized Medicine: Rapid Detection of SNPs in Drug Transporter Genes by the SmartAmp Method

(2011) W Aw et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Transporter-Mediated Drug–Drug Interactions

(2011) L Zhang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Transporter-Mediated Drug Uptake and Efflux: Important Determinants of Adverse Drug Reactions

(2011) O Zolk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

In-Silico ADME Models: A General Assessment of their Utility in Drug Discovery Applications

(2011) M. Paul Gleeson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular Biology of Nucleoside Transporters and their Distributions and Functions in the Brain

(2011) Fiona E. Parkinson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacogenetics: past, present and future

(2011) Munir Pirmohamed   DRUG DISCOVERY TODAY

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

(2011) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Clinical Importance of OATP1B1 and OATP1B3 in Drug­Drug Interactions

(2011) Yoshihisa Shitara   Drug Metabolism and Pharmacokinetics

Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of Drugs

(2011) Takeo Nakanishi et al.   Drug Metabolism and Pharmacokinetics

Pharmacogenomics of Tamoxifen: Roles of Drug Metabolizing Enzymes and Transporters

(2011) Kazuma Kiyotani et al.   Drug Metabolism and Pharmacokinetics

Human equilibrative nucleoside transporter 1 (hENT1) expression is a potential predictive tool for response to gemcitabine in patients with advanced cholangiocarcinoma

(2011) I. Borbath et al.   EUROPEAN JOURNAL OF CANCER

Pharmacogenomics and adverse drug reactions: the case of statins

(2011) Mariano A Giorgi et al.   EXPERT OPINION ON PHARMACOTHERAPY

Drug-permeability and transporter assays in Caco-2 and MDCK cell lines

(2011) Donna A Volpe   Future Medicinal Chemistry

Overcoming Communication Latency Barriers in Massively Parallel Scientific Computation

(2011) Ron Dror et al.   IEEE MICRO

Role of Dihydrolipoamide Dehydrogenase in Regulation of Raffinose Transport in Streptococcus pneumoniae

(2011) R. E. Tyx et al.   JOURNAL OF BACTERIOLOGY

Deletion of Multispecific Organic Anion Transporter Oat1/Slc22a6 Protects against Mercury-induced Kidney Injury

(2011) Adriana M. Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterizing the Diversity and Biological Relevance of the MLPCN Assay Manifold and Screening Set

(2011) Jintao Zhang et al.   Journal of Chemical Information and Modeling

6-mercaptopurine transport in human lymphocytes: Correlation with drug-induced cytotoxicity

(2011) Laurie S. CONKLIN et al.   Journal of Digestive Diseases

Human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy

(2011) Yasuhiro Murata et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Profiling of a Prescription Drug Library for Potential Renal Drug–Drug Interactions Mediated by the Organic Cation Transporter 2

(2011) Yasuto Kido et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

(2011) Renata M. Oballa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

(2011) Jeffrey A. Pfefferkorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative Targeted Absolute Proteomics-Based Adme Research as A New Path to Drug Discovery and Development: Methodology, Advantages, Strategy, and Prospects

(2011) Sumio Ohtsuki et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Contribution of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to hepatic uptake of nateglinide, and the prediction of drug-drug interactions via these transporters

(2011) Toshiyuki Takanohashi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging

(2011) György Marko-Varga et al.   Journal of Proteomics

Absolute Quantification of the Glycolytic Pathway in Yeast:

(2011) Kathleen M. Carroll et al.   MOLECULAR & CELLULAR PROTEOMICS

pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1

(2011) Manthena V. Varma et al.   MOLECULAR PHARMACEUTICS

Engineering microbial biofuel tolerance and export using efflux pumps

(2011) M. J. Dunlop et al.   Molecular Systems Biology

Controlled Translocation of Individual DNA Molecules through Protein Nanopores with Engineered Molecular Brakes

(2011) Marcela Rincon-Restrepo et al.   NANO LETTERS

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

(2011) Jan E Carette et al.   NATURE BIOTECHNOLOGY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

The BCS, BDDCS, and Regulatory Guidances

(2011) Mei-Ling Chen et al.   PHARMACEUTICAL RESEARCH

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

(2011) Piet H. van der Graaf et al.   PHARMACEUTICAL RESEARCH

Pharmacogenetics of drug transporters in the enterohepatic circulation

(2011) Bruno Stieger et al.   PHARMACOGENOMICS

Transporter-mediated drug–drug interactions

(2011) Fabian Müller et al.   PHARMACOGENOMICS

Understanding and Classifying Metabolite Space and Metabolite-Likeness

(2011) Julio E. Peironcely et al.   PLoS One

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

(2011) R. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knocking out the door to tunicamycin entry

(2011) M. C. Bassik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

(2011) J. H. Reiling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global absolute quantification of a proteome: Challenges in the deployment of a QconCAT strategy

(2011) Philip Brownridge et al.   PROTEOMICS

How Fast-Folding Proteins Fold

(2011) K. Lindorff-Larsen et al.   SCIENCE

Cell Membranes: The Lipid Perspective

(2011) Ünal Coskun et al.   STRUCTURE

Molecular Simulation Approaches to Membrane Proteins

(2011) Phillip J. Stansfeld et al.   STRUCTURE

Transporter mediated uptake and efflux of antiretroviral drugs: Potential for drug–drug interactions

(2011) Zoe Riches et al.   TOXICOLOGY

Hierarchical mesoscale domain organization of the plasma membrane

(2011) Akihiro Kusumi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biological membranes: the importance of molecular detail

(2011) Anthony G. Lee   TRENDS IN BIOCHEMICAL SCIENCES

MALDI imaging mass spectrometry: bridging biology and chemistry in drug development

(2011) Stephen Castellino et al.   Bioanalysis

Molecular obesity, potency and other addictions in drug discovery

(2011) Michael M. Hann   MedChemComm

A comparative analysis of the molecular topologies for drugs, clinical candidates, natural products, human metabolites and general bioactive compounds

(2011) Hongming Chen et al.   MedChemComm

Making sure there's a "give" associated with the "take": producing and using open-source software in big pharma

(2011) Gregory Landrum et al.   Journal of Cheminformatics

Structural diversity of biologically interesting datasets: a scaffold analysis approach

(2011) Varun Khanna et al.   Journal of Cheminformatics

Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs

(2011) Sabine Klatt et al.   Pharmaceutics

Association of Intergenic Polymorphism of Organic Anion Transporter 1 and 3 Genes With Hypertension and Blood Pressure Response to Hydrochlorothiazide

(2010) Y.-F. Han et al.   AMERICAN JOURNAL OF HYPERTENSION

Histology by Mass Spectrometry: Label-Free Tissue Characterization Obtained from High-Accuracy Bioanalytical Imaging

(2010) Andreas Römpp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Striking Species Difference in the Contribution of Concentrative Nucleoside Transporter 2 to Nucleoside Uptake between Mouse and Rat Hepatocytes

(2010) T. Furihata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immunocytochemistry for Amoxicillin and Its Use for Studying Uptake of the Drug in the Intestine, Liver, and Kidney of Rats

(2010) Kunio Fujiwara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Predicting Drug Disposition via Application of a Biopharmaceutics Drug Disposition Classification System

(2010) Leslie Z. Benet   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Molecular signatures-based prediction of enzyme promiscuity

(2010) Pablo Carbonell et al.   BIOINFORMATICS

Renal Secretion of Uric Acid by Organic Anion Transporter 2 (OAT2/SLC22A7) in Human

(2010) Masanobu Sato et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distribution

(2010) Jeffrey A. Pfefferkorn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models

(2010) Takahito Nakahara et al.   CANCER SCIENCE

Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study

(2010) L A Donnelly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evaluation of Drug Transporter Interactions in Drug Discovery and Development

(2010) Yurong Lai et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Human Equilibrative Nucleoside Transporter 1 (hENT1) Levels Predict Response to Gemcitabine in Patients With Biliary Tract Cancer (BTC)

(2010) D. Santini et al.   CURRENT CANCER DRUG TARGETS

Rational approaches to targeted polypharmacology: creating and navigating protein–ligand interaction networks

(2010) James T Metz et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs

(2010) L. Miraglia et al.   DRUG METABOLISM AND DISPOSITION

Tissue Distribution and Characterization of Drug-Related Material in Rats and Dogs after Repeated Oral Administration of Casopitant

(2010) S. Pagliarusco et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Severe Adverse Drug Reactions Using Pharmacogenetic Biomarkers

(2010) Masahiro Tohkin et al.   Drug Metabolism and Pharmacokinetics

Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects

(2010) Christina Fahrmayr et al.   DRUG METABOLISM REVIEWS

Clinical Implications of Pharmacogenetic Variation on the Effects of Statins

(2010) Simran D.S. Maggo et al.   DRUG SAFETY

Escherichia coli mar and acrAB Mutants Display No Tolerance to Simple Alcohols

(2010) Jonas Ankarloo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modeling Anesthetic Binding Sites within the Glycine Alpha One Receptor Based on Prokaryotic Ion Channel Templates: The Problem with TM4

(2010) Edward J. Bertaccini et al.   Journal of Chemical Information and Modeling

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter

(2010) Neils B Quashie et al.   MALARIA JOURNAL

Proteomics Profiling of Madin-Darby Canine Kidney Plasma Membranes Reveals Wnt-5a Involvement during Oncogenic H-Ras/TGF-β-mediated Epithelial-Mesenchymal Transition

(2010) Yuan-Shou Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Best Practices for QSAR Model Development, Validation, and Exploitation

(2010) Alexander Tropsha   Molecular Informatics

Alcohol- and Alcohol Antagonist-Sensitive Human GABAA Receptors: Tracking   Subunit Incorporation into Functional Receptors

(2010) P. Meera et al.   MOLECULAR PHARMACOLOGY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Role of Nucleoside Transporters in Nucleoside-Derived Drug Sensitivity

(2010) M. Molina-Arcas et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Pharmacogenomics and adverse drug reactions

(2010) Shashi Amur et al.   Personalized Medicine

Drug transporter pharmacogenetics in nucleoside-based therapies

(2010) Ekaitz Errasti-Murugarren et al.   PHARMACOGENOMICS

Exploring Transmembrane Diffusion Pathways With Molecular Dynamics

(2010) Yi Wang et al.   PHYSIOLOGY

Hijacking Solute Carriers for Proton-Coupled Drug Transport

(2010) Catriona M. H. Anderson et al.   PHYSIOLOGY

Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry

(2010) Anna Nilsson et al.   PLoS One

Emerging role for drug transporters at the blood–testis barrier

(2010) Dolores D. Mruk et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Organic cation transporter pharmacogenomics and drug–drug interaction

(2010) Anne T Nies et al.   Expert Review of Clinical Pharmacology

Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs

(2009) Arik Dahan et al.   AAPS Journal

Genome-Wide Identification of Saccharomyces cerevisiae Genes Required for Maximal Tolerance to Ethanol

(2009) M. C. Teixeira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Adverse drug reactions in childhood: a review of prospective studies and safety alerts

(2009) A Clavenna et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Physiochemical property space distribution among human metabolites, drugs and toxins

(2009) Varun Khanna et al.   BMC BIOINFORMATICS

Stereoselective transport and uptake of propranolol across human intestinal Caco-2 cell monolayers

(2009) Yi Wang et al.   CHIRALITY

Human Equilibrative Nucleoside Transporter 1 and Human Concentrative Nucleoside Transporter 3 Predict Survival after Adjuvant Gemcitabine Therapy in Resected Pancreatic Adenocarcinoma

(2009) R. Marechal et al.   CLINICAL CANCER RESEARCH

Molecular dynamics simulations of membrane channels and transporters

(2009) Fatemeh Khalili-Araghi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Pharmacogenetics of Drug Transporters

(2009) R. Franke et al.   CURRENT PHARMACEUTICAL DESIGN

Implications of the Dominant Role of Transporters in Drug Uptake by Cells (Supplementary Material)

(2009) Paul Dobson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

(2009) K. Zhou et al.   DIABETES

Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs

(2009) G. Ahlin et al.   DRUG METABOLISM AND DISPOSITION

Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant

(2009) T. Minematsu et al.   DRUG METABOLISM AND DISPOSITION

Systems Biology: The elements and principles of Life

(2009) Hans V. Westerhoff et al.   FEBS LETTERS

Multicenter Phase II Trial of YM155, a Small-Molecule Suppressor of Survivin, in Patients With Advanced, Refractory, Non–Small-Cell Lung Cancer

(2009) Giuseppe Giaccone et al.   JOURNAL OF CLINICAL ONCOLOGY

The Role of the Equilibrative Nucleoside Transporter 1 (ENT1) in Transport and Metabolism of Ribavirin by Human and Wild-Type or Ent1(-/-) Mouse Erythrocytes

(2009) C. J. Endres et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Role of Nucleoside Transporters in the Erythrocyte Disposition and Oral Absorption of Ribavirin in the Wild-Type and Equilibrative Nucleoside Transporter 1(-/-) Mice

(2009) C. J. Endres et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells

(2009) M. Tsuda et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects

(2009) Deepak Voora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin

(2009) Ying Chen et al.   Pharmacogenetics and Genomics

Pharmacogenomics of adverse drug reactions: practical applications and perspectives

(2009) Laurent Becquemont   PHARMACOGENOMICS

Clinical pharmacology and pharmacogenetics in a genomics era: the DMET platform

(2009) Tristan M Sissung et al.   PHARMACOGENOMICS

Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes

(2009) Emma C. Davies et al.   PLoS One

Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore

(2009) D. Stoddart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular dynamics of leucine and dopamine transporter proteins in a model cell membrane lipid bilayer

(2009) Patrick C. Gedeon et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Gemcitabine chemoresistance in pancreatic cancer: Molecular mechanisms and potential solutions

(2009) Roland Andersson et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE

Conciliating binding efficiency and polypharmacology

(2009) Jordi Mestres et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MALDI-FTICR Imaging Mass Spectrometry of Drugs and Metabolites in Tissue

(2008) Dale S. Cornett et al.   ANALYTICAL CHEMISTRY

Hospital Admissions Associated with Adverse Drug Reactions: A Systematic Review of Prospective Observational Studies

(2008) Chuenjid Kongkaew et al.   ANNALS OF PHARMACOTHERAPY

A comprehensive model of purine uptake by the malaria parasitePlasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites

(2008) Neils B. Quashie et al.   BIOCHEMICAL JOURNAL

Physiochemical drug properties associated with in vivo toxicological outcomes

(2008) Jason D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer

(2008) Nima Sharifi et al.   BJU INTERNATIONAL

Effect of SLCO1B3 Haplotype on Testosterone Transport and Clinical Outcome in Caucasian Patients with Androgen-Independent Prostatic Cancer

(2008) A. Hamada et al.   CLINICAL CANCER RESEARCH

Anton, a special-purpose machine for molecular dynamics simulation

(2008) David E. Shaw et al.   COMMUNICATIONS OF THE ACM

The Challenges of Dealing with Promiscuous Drug-Metabolizing Enzymes, Receptors and Transporters

(2008) Qiang Ma et al.   CURRENT DRUG METABOLISM

‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries

(2008) Paul D. Dobson et al.   DRUG DISCOVERY TODAY

High-Affinity Interaction of Sartans with H+/Peptide Transporters

(2008) I. Knutter et al.   DRUG METABOLISM AND DISPOSITION

Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells

(2008) T. Minematsu et al.   DRUG METABOLISM AND DISPOSITION

The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine

(2008) S. Matsushima et al.   DRUG METABOLISM AND DISPOSITION

Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters

(2008) X. Ming et al.   DRUG METABOLISM AND DISPOSITION

Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human

(2008) Meng Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer

(2008) James J. Farrell et al.   GASTROENTEROLOGY

The Human Protein Atlas-a tool for pathology

(2008) F Pontén et al.   JOURNAL OF PATHOLOGY

Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol

(2008) Yukio Kato et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mouse Organic Anion Transporter 2 (mOat2) Mediates the Transport of Short Chain Fatty Acid Propionate

(2008) Rafiqul Islam et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Transport of Angiotensin-Converting Enzyme Inhibitors by H+/Peptide Transporters Revisited

(2008) I. Knutter et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

(2008) Markus J Herrgård et al.   NATURE BIOTECHNOLOGY

Combination chemical genetics

(2008) Joseph Lehár et al.   Nature Chemical Biology

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacogenomics and Drug Toxicity

(2008) Yusuke Nakamura   NEW ENGLAND JOURNAL OF MEDICINE

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Physiological and Pharmacological Roles of Nucleoside Transporter Proteins

(2008) Míriam Molina-Arcas et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

The Use of BDDCS in Classifying the Permeability of Marketed Drugs

(2008) Leslie Z. Benet et al.   PHARMACEUTICAL RESEARCH

The Contributions of Paul Ehrlich to Pharmacology: A Tribute on the Occasion of the Centenary of His Nobel Prize

(2008) Fèlix Bosch et al.   PHARMACOLOGY

GABAA receptors and alcohol

(2008) Ingrid A. Lobo et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protein area occupancy at the center of the red blood cell membrane

(2008) A. D. Dupuy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of Drug Transporters in Pharmacokinetics and Drug Safety

(2008) Peter Ward   TOXICOLOGY MECHANISMS AND METHODS

Drug:H+ antiporters in chemical stress response in yeast

(2008) Isabel Sá-Correia et al.   TRENDS IN MICROBIOLOGY

Physiology, structure, and regulation of the cloned organic anion transporters

(2008) C. Srimaroeng et al.   XENOBIOTICA

Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol

(2007) Istvan Mody   NEUROCHEMISTRY INTERNATIONAL

GABAA receptor subtypes underlying general anesthesia

(2007) Robert P. Bonin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR