Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetic Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms

(2012) Kenta Yoshida et al.   Annual Review of Pharmacology and Toxicology

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

(2012) Yoshihisa Shitara et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Species differences in drug transporters and implications for translating preclinical findings to humans

(2012) Xiaoyan Chu et al.   Expert Opinion on Drug Metabolism & Toxicology

PET Imaging-Based Evaluation of Hepatobiliary Transport in Humans with (15R)-11C-TIC-Me

(2012) T. Takashima et al.   JOURNAL OF NUCLEAR MEDICINE

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

(2012) Michael Gertz et al.   PHARMACEUTICAL RESEARCH

Uptake Rate of Cationic Mitochondrial Inhibitor MKT-077 Determines Cellular Oxygen Consumption Change in Carcinoma Cells

(2012) John L. Chunta et al.   PLoS One

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

Effect of ABCC2 (MRP2) Transport Function on Erythromycin Metabolism

(2011) R M Franke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study

(2011) K Maeda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

(2011) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Kinetic Characterization of Rat Hepatic Uptake of 16 Actively Transported Drugs

(2011) Y. Yabe et al.   DRUG METABOLISM AND DISPOSITION

Toward a new age of cellular pharmacokinetics in drug discovery

(2011) Fang Zhou et al.   DRUG METABOLISM REVIEWS

Effect of Lapatinib on Hepatic Parenchymal Enhancement on Gadoxetate Disodium (EOB)-Enhanced MRI Scans

(2011) Yuko Nakamura et al.   JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY

The Involvement of Organic Anion Transporting Polypeptide in the Hepatic Uptake of Telmisartan in Rats: PET Studies with [11C]Telmisartan

(2011) Tadayuki Takashima et al.   MOLECULAR PHARMACEUTICS

The Subcellular Distribution of Small Molecules: A Meta-Analysis

(2011) Nan Zheng et al.   MOLECULAR PHARMACEUTICS

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

Hepatic Metabolism and Transporter Gene Variants Enhance Response to Rosuvastatin in Patients With Acute Myocardial Infarction

(2010) Kristian M. Bailey et al.   Circulation-Cardiovascular Genetics

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

(2010) M. Friden et al.   DRUG METABOLISM AND DISPOSITION

Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters

(2010) M. Leonhardt et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters

(2010) Hiroyuki Kusuhara et al.   DRUG METABOLISM REVIEWS

Effects of a P-glycoprotein modulator on the pharmacokinetics and distribution of free levobupivacaine and bupivacaine in rats

(2010) Yu-Tse Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

(2010) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates

(2010) Tatsuhiko Tachibana et al.   PHARMACEUTICAL RESEARCH

Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3

(2009) Rajgopal Govindarajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin

(2009) J E Keskitalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

(2009) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

(2009) Agnès Poirier et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Hepatobiliary Disposition of Troglitazone and Metabolites in Rat and Human Sandwich-Cultured Hepatocytes: Use of Monte Carlo Simulations to Assess the Impact of Changes in Biliary Excretion on Troglitazone Sulfate Accumulation

(2009) J. K. Lee et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Scientific and Regulatory Perspectives on Metabolizing Enzyme−Transporter Interplay and Its Role in Drug Interactions: Challenges in Predicting Drug Interactions†

(2009) Lei Zhang et al.   MOLECULAR PHARMACEUTICS

Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

(2009) Agnès Poirier et al.   MOLECULAR PHARMACEUTICS

Interplay of Transporters and Enzymes in Drug and Metabolite Processing

(2009) K. Sandy Pang et al.   MOLECULAR PHARMACEUTICS

Compensatory Induction of Liver Efflux Transporters in Response to ANIT-Induced Liver Injury Is Impaired in FXR-Null Mice

(2009) Yue J. Cui et al.   TOXICOLOGICAL SCIENCES

Direct visualization and quantification of the anticancer agent, cis-diamminedichloro-platinum(II), in human lung cancer cells using in-air microparticle-induced X-ray emission analysis

(2008) Hideyuki Sakurai et al.   CANCER SCIENCE

Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the In vivo Elimination of Methotrexate and its Main Toxic Metabolite 7-hydroxymethotrexate

(2008) M. L.H. Vlaming et al.   CLINICAL CANCER RESEARCH

Relationship between Drug/Metabolite Exposure and Impairment of Excretory Transport Function

(2008) M. J. Zamek-Gliszczynski et al.   DRUG METABOLISM AND DISPOSITION

Recent advances in the analysis of biological particles by capillary electrophoresis

(2008) Vratislav Kostal et al.   ELECTROPHORESIS

Determination of ascorbic acid in individual rat hepatocyte by capillary electrophoresis with electrochemical detection

(2008) Xuemei Sun et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

(2008) T. Watanabe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

(2008) Giulia Ghibellini et al.   PHARMACEUTICAL RESEARCH

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

(2008) B. Hagenbuch et al.   XENOBIOTICA