Pharmacogenomics of adverse drug reactions

Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine

(2012) Melissa A. Frasco et al.   AIDS

Abacavir induces loading of novel self-peptides into HLA-B*57

(2012) Michael A. Norcross et al.   AIDS

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

(2012) A. Albrechtsen et al.   DIABETOLOGIA

Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome

(2012) Chun-Yu Wei et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

(2012) Yalda Jamshidi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis

(2012) Mary J Emond et al.   NATURE GENETICS

Genomewide Pharmacogenetics of Bisphosphonate-Induced Osteonecrosis of the Jaw: The Role of RBMS3

(2012) P. Nicoletti et al.   ONCOLOGIST

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs

(2012) Thomas J. Urban et al.   Pharmacogenetics and Genomics

HLA and pharmacogenetics of drug hypersensitivity

(2012) Rebecca Pavlos et al.   PHARMACOGENOMICS

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

(2012) D. A. Ostrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent

(2011) Jing Yuan et al.   AIDS

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

(2011) R. E. Dickinson et al.   BLOOD

A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes

(2011) Stefan Kääb et al.   Circulation-Cardiovascular Genetics

Genome-wide Association Study Identifies Variations in 6p21.3 Associated With Nevirapine-Induced Rash

(2011) Soranun Chantarangsu et al.   CLINICAL INFECTIOUS DISEASES

A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity

(2011) I G Metushi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic association studies in drug-induced liver injury

(2011) Ann K. Daly et al.   DRUG METABOLISM REVIEWS

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw

(2011) J. Katz et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome

(2011) Tai-Ming Ko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

(2011) Mark McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe

(2011) Emmanuelle Génin et al.   Orphanet Journal of Rare Diseases

Genome-wide association study of serious blistering skin rash caused by drugs

(2011) Y Shen et al.   PHARMACOGENOMICS JOURNAL

Delayed drug hypersensitivity: models of T-cell stimulation

(2010) Jacqueline Adam et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study

(2010) L A Donnelly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A role for the pregnane X receptor in flucloxacillin-induced liver injury

(2010) Elise Andrews et al.   HEPATOLOGY

Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population

(2010) Takeshi Ozeki et al.   HUMAN MOLECULAR GENETICS

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

(2010) S. Tamir Rashid et al.   JOURNAL OF CLINICAL INVESTIGATION

Candidate Gene Analysis Identifies a Polymorphism inHLA-DQB1Associated With Clozapine-Induced Agranulocytosis

(2010) Maria C. Athanasiou et al.   JOURNAL OF CLINICAL PSYCHIATRY

Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis

(2010) Purabi Deka Bose et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Genome-wide association study of antipsychotic-induced QTc interval prolongation

(2010) K Åberg et al.   PHARMACOGENOMICS JOURNAL

Drug-Induced Long QT Syndrome

(2010) P. Kannankeril et al.   PHARMACOLOGICAL REVIEWS

Transporter Pharmacogenetics and Statin Toxicity

(2009) M Niemi   CLINICAL PHARMACOLOGY & THERAPEUTICS

Human drug hepatotoxicity: a contemporary clinical perspective

(2009) David N Assis et al.   Expert Opinion on Drug Metabolism & Toxicology

Toxic and drug-induced myopathies

(2009) M C Dalakas   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

D85N, a KCNE1 Polymorphism, Is a Disease-Causing Gene Variant in Long QT Syndrome

(2009) Yukiko Nishio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects

(2009) Deepak Voora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Common variants at ten loci influence QT interval duration in the QTGEN Study

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation

(2009) Charlotte van Noord et al.   Pharmacogenetics and Genomics

High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients

(2009) Gbenga R. Kazeem et al.   Pharmacogenetics and Genomics

HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients

(2009) Soranun Chantarangsu et al.   Pharmacogenetics and Genomics

Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis

(2009) Sang-Heon Kim et al.   PHARMACOGENOMICS

Genetic variations ofNAT2andCYP2E1and isoniazid hepatotoxicity in a diverse population

(2009) So Yamada et al.   PHARMACOGENOMICS

Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies

(2009) Ilja M. Nolte et al.   PLoS One

Immunoallergic Drug-Induced Liver Injury in Humans

(2009) Jack Uetrecht   SEMINARS IN LIVER DISEASE

The Natural History of Drug-Induced Liver Injury

(2009) Einar Björnsson   SEMINARS IN LIVER DISEASE

STAT4: Genetics, mechanisms, and implications for autoimmunity

(2008) Benjamin D. Korman et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil

(2008) L. G. Possuelo et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia

(2008) S Volpi et al.   MOLECULAR PSYCHIATRY

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A European study of HLA-B in Stevens???Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs

(2008) Christine Lonjou et al.   Pharmacogenetics and Genomics