Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetic Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

(2012) Yoshihisa Shitara et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP

(2012) Hiroyuki Kusuhara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transporter-Mediated Drug–Drug Interactions Involving OATP Substrates: Predictions Based on In Vitro Inhibition Studies

(2012) K Yoshida et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Increased Systemic Exposure of Fimasartan, an Angiotensin II Receptor Antagonist, by Ketoconazole and Rifampicin

(2012) Jung Won Kim et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Expression and Transport Function of Drug Uptake Transporters in Differentiated HepaRG Cells

(2012) Naoki Kotani et al.   MOLECULAR PHARMACEUTICS

Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3

(2012) Keiji Shimizu et al.   NUCLEAR MEDICINE AND BIOLOGY

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture

(2011) Maria Ulvestad et al.   BIOCHEMICAL PHARMACOLOGY

Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum

(2011) Theodora G.H.A. Tucker et al.   BIOCHEMICAL PHARMACOLOGY

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

(2011) Atsushi Yonezawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

PBPK Modeling of Intestinal and Liver Enzymes and Transporters in Drug Absorption and Sequential Metabolism

(2011) Jianghong Fan et al.   CURRENT DRUG METABOLISM

Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model

(2011) A. S. Darwich et al.   CURRENT DRUG METABOLISM

Organic Anion Transporting Polypeptides (OATPs): Regulation of Expression and Function

(2011) Martin Svoboda et al.   CURRENT DRUG METABOLISM

Hepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4

(2011) A. J. Wilby et al.   DRUG METABOLISM AND DISPOSITION

Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes

(2011) N. Kotani et al.   DRUG METABOLISM AND DISPOSITION

Prediction of the Overall Renal Tubular Secretion and Hepatic Clearance of Anionic Drugs and a Renal Drug-Drug Interaction Involving Organic Anion Transporter 3 in Humans by In Vitro Uptake Experiments

(2011) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of Drugs

(2011) Takeo Nakanishi et al.   Drug Metabolism and Pharmacokinetics

The effect of grapefruit juice on drug disposition

(2011) Michael J Hanley et al.   Expert Opinion on Drug Metabolism & Toxicology

Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose and Therapeutic Dose

(2011) Ichiro Ieiri et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Disposition of Atorvastatin, Rosuvastatin, and Simvastatin in Oatp1b2-/- Mice and Intraindividual Variability in Human Subjects

(2011) M. K. DeGorter et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Prediction of Nonlinear Intestinal Absorption of CYP3A4 and P-Glycoprotein Substrates from their In Vitro Km Values

(2011) Tatsuhiko Tachibana et al.   PHARMACEUTICAL RESEARCH

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles

(2011) Lei Gong et al.   TOXICOLOGICAL SCIENCES

Loss of Organic Anion Transporting Polypeptide 1a1 Increases Deoxycholic Acid Absorption in Mice by Increasing Intestinal Permeability

(2011) Youcai Zhang et al.   TOXICOLOGICAL SCIENCES

Fruit juice inhibition of uptake transport: a new type of food-drug interaction

(2010) David G. Bailey   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

ABCG2 Polymorphism Is Associated With the Low-Density Lipoprotein Cholesterol Response to Rosuvastatin

(2010) B Tomlinson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hepatic Uptake of the Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA: Role of Human Organic Anion Transporters

(2010) M. Leonhardt et al.   DRUG METABOLISM AND DISPOSITION

ABCC2/Abcc2: a multispecific transporter with dominant excretory functions

(2010) Katalin Jemnitz et al.   DRUG METABOLISM REVIEWS

Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice

(2010) Iván L. Csanaky et al.   HEPATOLOGY

Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

(2010) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans

(2010) Takao Watanabe et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Positron Emission Tomography Studies Using (15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin Methyl Ester for the Evaluation of Hepatobiliary Transport

(2010) T. Takashima et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Improved Extrapolation of Hepatobiliary Clearance fromin VitroSandwich Cultured Rat Hepatocytes through Absolute Quantification of Hepatobiliary Transporters

(2010) Na Li et al.   MOLECULAR PHARMACEUTICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans

(2010) Junko Imanaga et al.   Pharmacogenetics and Genomics

Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers

(2010) Yumiko Akamine et al.   XENOBIOTICA

Differential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors

(2010) Min-Koo Choi et al.   XENOBIOTICA

LC−MS/MS Mediated Absolute Quantification and Comparison of Bile Salt Export Pump and Breast Cancer Resistance Protein in Livers and Hepatocytes across Species

(2009) Na Li et al.   ANALYTICAL CHEMISTRY

The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin

(2009) M V Tzvetkov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

(2009) M. L. Becker et al.   DIABETES

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

(2009) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments

(2009) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

ABCC2/Abcc2 Transport Property in Different Species and its Modulation by Heterogeneous Factors

(2009) Kousei Ito   Drug Metabolism and Pharmacokinetics

In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney

(2009) Hiroyuki Kusuhara et al.   Drug Metabolism and Pharmacokinetics

Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls

(2009) Matthias Brandsch   Expert Opinion on Drug Metabolism & Toxicology

OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids

(2009) Nazzareno Ballatori   Frontiers in Bioscience-Landmark

Oral Sulfasalazine as a Clinical BCRP Probe Substrate: Pharmacokinetic Effects of Genetic Variation (C421A) and Pantoprazole Coadministration

(2009) Kimberly K. Adkison et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

(2009) Agnès Poirier et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat

(2009) Y. Shirasaka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response

(2009) Edward B. Mougey et al.   Pharmacogenetics and Genomics

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

(2009) H. Matsuo et al.   Science Translational Medicine

Method for predicting the risk of drug–drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein

(2009) T. Tachibana et al.   XENOBIOTICA

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

ABCG2: A perspective

(2008) Robert W. Robey et al.   ADVANCED DRUG DELIVERY REVIEWS

Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans

(2008) Y Yamasaki et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Utility of a Novel Oatp1b2 Knockout Mouse Model for Evaluating the Role of Oatp1b2 in the Hepatic Uptake of Model Compounds

(2008) C. Chen et al.   DRUG METABOLISM AND DISPOSITION

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

(2008) S. W. Paine et al.   DRUG METABOLISM AND DISPOSITION

Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human

(2008) N. Li et al.   DRUG METABOLISM AND DISPOSITION

Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin

(2008) S. Kitamura et al.   DRUG METABOLISM AND DISPOSITION

Identification and Species Similarity of OATP Transporters Responsible for Hepatic Uptake of β-Lactam Antibiotics

(2008) Masanori Nakakariya et al.   Drug Metabolism and Pharmacokinetics

Impact of Genetic Polymorphisms of Transporters on the Pharmacokinetic, Pharmacodynamic and Toxicological Properties of Anionic Drugs

(2008) Kazuya Maeda et al.   Drug Metabolism and Pharmacokinetics

In vitro–in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

(2008) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Caco-2 cell monolayer: usefulness and limitations

(2008) Huadong Sun et al.   Expert Opinion on Drug Metabolism & Toxicology

Utilization of membrane vesicle preparations to study drug–ABC transporter interactions

(2008) Hristos Glavinas et al.   Expert Opinion on Drug Metabolism & Toxicology

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

(2008) T. Watanabe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison with in Vivo Biliary Clearance

(2008) K. Abe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

Knocking Down Breast Cancer Resistance Protein (Bcrp) by Adenoviral Vector-Mediated RNA Interference (RNAi) in Sandwich-Cultured Rat Hepatocytes: A Novel Tool To Assess the Contribution of Bcrp to Drug Biliary Excretion

(2008) Wei Yue et al.   MOLECULAR PHARMACEUTICS

Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin

(2008) H. Zaher et al.   MOLECULAR PHARMACOLOGY

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

(2008) Giulia Ghibellini et al.   PHARMACEUTICAL RESEARCH

Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe

(2008) Bradley L. Urquhart et al.   Pharmacogenetics and Genomics

Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR

(2008) Hong Lu et al.   TOXICOLOGICAL SCIENCES

A regulatory viewpoint on transporter-based drug interactions

(2008) L. Zhang et al.   XENOBIOTICA