Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs

Functional Characteristics of Two Human MATE Transporters: Kinetics of Cimetidine Transport and Profiles of Iinhibition by Various Compounds

(2016) Kin-ya Ohta et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis

(2012) K Toyama et al.   BRITISH JOURNAL OF PHARMACOLOGY

Twelve Transmembrane Helices Form the Functional Core of Mammalian MATE1 (Multidrug and Toxin Extruder 1) Protein

(2012) Xiaohong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Perpetual Challenge of Infectious Diseases

(2012) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

Molecular Mechanism of Renal Tubular Secretion of the Antimalarial Drug Chloroquine

(2011) Fabian Müller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

(2011) Atsushi Yonezawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Use of Transgenic and Knockout Mouse Models to Assess Solute Carrier Transporter Function

(2011) M K DeGorter et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Common 5′-UTR Variant in MATE2-K Is Associated With Poor Response to Metformin

(2011) J H Choi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects

(2011) H Kusuhara et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics

(2011) Katja Damme et al.   DRUG METABOLISM REVIEWS

Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter

(2011) Toshinori Komatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Profiling of a Prescription Drug Library for Potential Renal Drug–Drug Interactions Mediated by the Organic Cation Transporter 2

(2011) Yasuto Kido et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deficiency of Multidrug and Toxin Extrusion 1 Enhances Renal Accumulation of Paraquat and Deteriorates Kidney Injury in Mice

(2011) Qing Li et al.   MOLECULAR PHARMACEUTICS

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

(2011) Elke Schaeffeler et al.   Genome Medicine

Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity

(2010) Takanori Nakamura et al.   BIOCHEMICAL PHARMACOLOGY

Organic cation transporter OCT/SLC22A and H+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents

(2010) Atsushi Yonezawa et al.   BIOCHEMICAL PHARMACOLOGY

Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations

(2010) J König et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prediction of Fluoroquinolone-Induced Elevation in Serum Creatinine Levels: A Case of Drug–Endogenous Substance Interaction Involving the Inhibition of Renal Secretion

(2010) Y Imamura et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Potent and Specific Inhibition of mMate1-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine

(2010) S. Ito et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Reduced Renal Clearance of a Zwitterionic Substrate Cephalexin in Mate1-Deficient Mice

(2010) S. Watanabe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Preclinical and Clinical Evidence for the Collaborative Transport and Renal Secretion of an Oxazolidinone Antibiotic by Organic Anion Transporter 3 (OAT3/SLC22A8) and Multidrug and Toxin Extrusion Protein 1 (MATE1/SLC47A1)

(2010) Y. Lai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

DNA Methylation Profiles of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines

(2010) Sayaka Ichihara et al.   PHARMACEUTICAL RESEARCH

Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients

(2010) Kana Toyama et al.   Pharmacogenetics and Genomics

Alterations in Hepatic mRNA Expression of Phase II Enzymes and Xenobiotic Transporters after Targeted Disruption of Hepatocyte Nuclear Factor 4 Alpha

(2010) Hong Lu et al.   TOXICOLOGICAL SCIENCES

Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration

(2009) Julius O. Soyinka et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin

(2009) M V Tzvetkov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

(2009) M. L. Becker et al.   DIABETES

Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity

(2009) Moto Kajiwara et al.   JOURNAL OF HUMAN GENETICS

Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells

(2009) M. Tsuda et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacogenetics of antimalarial drugs: effect on metabolism and transport

(2009) Reinhold Kerb et al.   LANCET INFECTIOUS DISEASES

Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin

(2009) M. Tsuda et al.   MOLECULAR PHARMACOLOGY

Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1

(2009) Ji Ha Choi et al.   Pharmacogenetics and Genomics

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function

(2009) Ying Chen et al.   PHARMACOGENOMICS JOURNAL

Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression and Promoter Activity Predict Variation

(2009) Stephanie E. Hesselson et al.   PLoS One

Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1

(2008) Tomoko Sato et al.   BIOCHEMICAL PHARMACOLOGY

Functional Characterization of Multidrug and Toxin Extrusion Protein 1 as a Facilitative Transporter for Fluoroquinolones

(2008) K.-y. Ohta et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice

(2008) Andrew J. Lickteig et al.   LIFE SCIENCES

Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics

(2008) Y. Moriyama et al.   XENOBIOTICA

A novel variant of mouse MATE-1 H+/organic cation antiporter with a long hydrophobic tail

(2007) Ayumi Kobara et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A)

(2007) Tomohiro Terada et al.   BIOCHEMICAL PHARMACOLOGY