Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Microsecond Simulations Indicate that Ethanol Binds between Subunits and Could Stabilize an Open-State Model of a Glycine Receptor

(2011) Samuel Murail et al.   BIOPHYSICAL JOURNAL

Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels

(2011) Stuart A. Forman et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Structure of the M2 Transmembrane Segment of GLIC, a Prokaryotic Cys Loop Receptor Homologue fromGloeobacter violaceus, Probed by Substituted Cysteine Accessibility

(2011) Rishi B. Parikh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

(2011) G. Duret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bridging the Gap between Structural Models of Nicotinic Receptor Superfamily Ion Channels and Their Corresponding Functional States

(2010) Giovanni Gonzalez-Gutierrez et al.   JOURNAL OF MOLECULAR BIOLOGY

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels

(2010) John E. Baenziger et al.   NEUROPHARMACOLOGY

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

(2010) H. Nury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel

(2009) Yun Weng et al.   ANESTHESIA AND ANALGESIA

Fpocket: An open source platform for ligand pocket detection

(2009) Vincent Le Guilloux et al.   BMC BIOINFORMATICS

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

Ethanol's Molecular Targets

(2008) R. A. Harris et al.   Science Signaling

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY

Molecular dynamics simulations of ethanol binding to the transmembrane domain of the glycine receptor: Implications for the channel potentiation mechanism

(2007) Mary Hongying Cheng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS