Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma

(2018) Hirokazu Sadahiro et al.   CANCER RESEARCH

A highlight on Sonic hedgehog pathway

(2018) Gabriela Basile Carballo et al.   Cell Communication and Signaling

Brain-Cortex Microglia-Derived Exosomes: Nanoparticles for Glioma Therapy

(2018) Adriana-Natalia Murgoci et al.   CHEMPHYSCHEM

NGF steers microglia toward a neuroprotective phenotype

(2018) Caterina Rizzi et al.   GLIA

Glioma infiltration and extracellular matrix: key players and modulators

(2018) Valéria Pereira Ferrer et al.   GLIA

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

(2018) Saskia Roesch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma

(2018) Antonin Dréan et al.   JOURNAL OF NEURO-ONCOLOGY

Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes

(2018) Jiawen Xu et al.   Journal of Neuroinflammation

Comparative dynamics of microglial and glioma cell motility at the infiltrative margin of brain tumours

(2018) Joseph Juliano et al.   Journal of the Royal Society Interface

Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors

(2018) Erhao Zhang et al.   Molecular Cancer

GBM-Derived Wnt3a Induces M2-Like Phenotype in Microglial Cells Through Wnt/β-Catenin Signaling

(2018) Diana Matias et al.   MOLECULAR NEUROBIOLOGY

Reactive Astrocytes in Glioblastoma Multiforme

(2018) Xiudong Guan et al.   MOLECULAR NEUROBIOLOGY

Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-κB signaling pathway

(2018) Peng Jin et al.   ONCOGENE

Central inhibition of granulocyte-macrophage colony-stimulating factor is analgesic in experimental neuropathic pain

(2018) Louise S.C. Nicol et al.   PAIN

Constitutive and TNFα-inducible expression of chondroitin sulfate proteoglycan 4 in glioblastoma and neurospheres: Implications for CAR-T cell therapy

(2018) Serena Pellegatta et al.   Science Translational Medicine

Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain

(2018) Francesca L'Episcopo et al.   Frontiers in Aging Neuroscience

The immune checkpoint protein PD-L1 induces and maintains regulatory T cells in glioblastoma

(2018) Joseph DiDomenico et al.   OncoImmunology

Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce Glioma Stem Cell Niches at the Tumor Border

(2018) Takuichiro Hide et al.   EBioMedicine

Mutant IDH1 regulates the tumor-associated immune system in gliomas

(2017) Nduka M. Amankulor et al.   GENES & DEVELOPMENT

VEGF as a modulator of the innate immune response in glioblastoma

(2017) Kati Turkowski et al.   GLIA

Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns

(2017) Joshua G. Jackson et al.   GLIA

Bioenergetic regulation of microglia

(2017) Soumitra Ghosh et al.   GLIA

Major Challenges and Potential Microenvironment-Targeted Therapies in Glioblastoma

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance

(2017) Romana-Rea Begicevic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immune microenvironment of gliomas

(2017) Anna Gieryng et al.   LABORATORY INVESTIGATION

Microglial Function during Glucose Deprivation: Inflammatory and Neuropsychiatric Implications

(2017) Matthew A. Churchward et al.   MOLECULAR NEUROBIOLOGY

Blockade of CCR5 receptor prevents M2 microglia phenotype in a microglia-glioma paradigm

(2017) Emilia Laudati et al.   NEUROCHEMISTRY INTERNATIONAL

CCL2/CCR2 signaling pathway in glioblastoma multiforme

(2017) Alireza Vakilian et al.   NEUROCHEMISTRY INTERNATIONAL

Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis

(2017) Ming-Liang Zhang et al.   NEUROSCIENCE LETTERS

Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma

(2017) L. Lisi et al.   NEUROSCIENCE LETTERS

Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications

(2017) Tamara J. Abou-Antoun et al.   Neurotherapeutics

Tumor-derived fibulin-3 activates pro-invasive NF-κB signaling in glioblastoma cells and their microenvironment

(2017) M S Nandhu et al.   ONCOGENE

Glioblastoma entities express subtle differences in molecular composition and response to treatment

(2017) Joana Balça-Silva et al.   ONCOLOGY REPORTS

Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype

(2017) Soliman Oushy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells

(2017) Joana Balça-Silva et al.   Translational Oncology

Regulatory Roles of Long Non-Coding RNAs in the Central Nervous System and Associated Neurodegenerative Diseases

(2017) Zhenzhen Quan et al.   Frontiers in Cellular Neuroscience

Microglia immunophenotyping in gliomas

(2017) Laura Annovazzi et al.   Oncology Letters

Dual treatment with shikonin and temozolomide reduces glioblastoma tumor growth, migration and glial-to-mesenchymal transition

(2017) Diana Matias et al.   CELLULAR ONCOLOGY

ABCG2 downregulation in glioma stem cells enhances the therapeutic efficacy of demethoxycurcumin

(2017) Long Chen et al.   Oncotarget

Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival

(2017) Yuan Pan et al.   Oncotarget

Ephrin-B3 supports glioblastoma growth by inhibiting apoptosis induced by the dependence receptor EphA4

(2017) Amélie Royet et al.   Oncotarget

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight

(2017) Hamoud Al-Khallaf   Cell and Bioscience

Environmental stimuli shape microglial plasticity in glioma

(2017) Stefano Garofalo et al.   eLife

Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases

(2017) Federica Ciregia et al.   Frontiers in Molecular Neuroscience

ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

(2017) Francesco Drago et al.   Frontiers in Pharmacology

Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy

(2017) Xiao Zhao et al.   Acta Pharmaceutica Sinica B

Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion

(2017) Alison Roos et al.   Frontiers in Oncology

The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells

(2017) Alessandra Audia et al.   Frontiers in Oncology

Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype

(2017) Nina Xue et al.   Scientific Reports

Immune microenvironment of experimental rat C6 gliomas resembles human glioblastomas

(2017) Anna Gieryng et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

(2016) J. M. Pitt et al.   ANNALS OF ONCOLOGY

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models

(2016) David M. Irvin et al.   BRAIN PATHOLOGY

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages

(2016) I. De et al.   CANCER RESEARCH

Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+exchanger isoform 1

(2016) Wen Zhu et al.   CARCINOGENESIS

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Role of Molecular Diagnostics in the Management of Patients with Gliomas

(2016) Hans-Georg Wirsching et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

ABC transporters as mediators of drug resistance and contributors to cancer cell biology

(2016) Jamie I. Fletcher et al.   DRUG RESISTANCE UPDATES

The role of the tumor microenvironment in glioblastoma: A mathematical model

(2016) Yangjin Kim et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model

(2016) Laura Mercurio et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosomal miR-221 targets DNM3 to induce tumor progression and temozolomide resistance in glioma

(2016) Jian-Kai Yang et al.   JOURNAL OF NEURO-ONCOLOGY

Radiotherapy induces an immediate inflammatory reaction in malignant glioma: a clinical microdialysis study

(2016) Pedram Tabatabaei et al.   JOURNAL OF NEURO-ONCOLOGY

Balancing the immune response in the brain: IL-10 and its regulation

(2016) Diogo Lobo-Silva et al.   Journal of Neuroinflammation

Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling

(2016) Omar Dildar a Dzaye et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types

(2016) Michael D. Iglesia et al.   JNCI-Journal of the National Cancer Institute

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

(2016) Carolina Cunha et al.   MEDIATORS OF INFLAMMATION

Malignant gliomas induce and exploit astrocytic mesenchymal-like transition by activating canonical Wnt/β-catenin signaling

(2016) Ping Lu et al.   MEDICAL ONCOLOGY

Wnt3a suppresses Pseudomonas aeruginosa-induced inflammation and promotes bacterial killing in macrophages

(2016) KANG CHEN et al.   Molecular Medicine Reports

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Decrease of VEGF-A in myeloid cells attenuates glioma progression and prolongs survival in an experimental glioma model

(2016) Nadja Osterberg et al.   NEURO-ONCOLOGY

IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression

(2016) Xiaoran Zhang et al.   NEURO-ONCOLOGY

Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression

(2016) A Ellert-Miklaszewska et al.   ONCOGENE

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

(2016) Jonas Kloepper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14

(2016) Weiliang Chen et al.   Oncotarget

Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

(2016) Jeremy T. Miyauchi et al.   Oncotarget

Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types

(2016) Michael D. Iglesia et al.   JNCI-Journal of the National Cancer Institute

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

Characterization of Arginase Expression in Glioma-Associated Microglia and Macrophages

(2016) Ian Zhang et al.   PLoS One

Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion

(2015) Lanfu Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors

(2015) Susan Brandenburg et al.   ACTA NEUROPATHOLOGICA

Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines

(2015) Joana Balça-Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Actin dynamics shape microglia effector functions

(2015) Ria Uhlemann et al.   Brain Structure & Function

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages

(2015) Judy Choi et al.   CANCER BIOLOGY & THERAPY

TGF  Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response

(2015) J. Han et al.   CANCER RESEARCH

Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and Interpretations

(2015) K. Rycaj et al.   CANCER RESEARCH

Clinical Neuropathology mini-review 6-2015: PD-L1: emerging biomarker in glioblastoma?

(2015) Matthias Preusser et al.   CLINICAL NEUROPATHOLOGY

Long non‐coding RNAs in corticogenesis: deciphering the non‐coding code of the brain

(2015) Julieta Aprea et al.   EMBO JOURNAL

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes

(2015) Jacomijn P. Dijksterhuis et al.   EXPERIMENTAL CELL RESEARCH

Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation

(2015) Amol Suryawanshi et al.   JOURNAL OF IMMUNOLOGY

miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients

(2015) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Differential expression and clinical significance of three inflammation-related microRNAs in gangliogliomas

(2015) A. S. Prabowo et al.   Journal of Neuroinflammation

Non-signalling energy use in the brain

(2015) Elisabeth Engl et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes

(2015) Weiliang Chen et al.   MEDICAL ONCOLOGY

Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer

(2015) S.S. Islam et al.   MOLECULAR CARCINOGENESIS

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation

(2015) Shuli Xia et al.   NEURO-ONCOLOGY

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

(2015) Kristan E. van der Vos et al.   NEURO-ONCOLOGY

TMEM119 marks a subset of microglia in the human brain

(2015) Jun-ichi Satoh et al.   NEUROPATHOLOGY

MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment

(2015) F J Kohlhapp et al.   ONCOGENE

Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired Immunosuppression

(2015) Peter C. Huszthy et al.   PLoS One

Microglia in Health and Disease

(2015) Richard M. Ransohoff et al.   Cold Spring Harbor Perspectives in Biology

Cell of Origin for Malignant Gliomas and Its Implication in Therapeutic Development

(2015) Hui Zong et al.   Cold Spring Harbor Perspectives in Biology

Distribution and characterization of tumor-associated macrophages/microglia in rat C6 glioma

(2015) ZHI-MING ZHANG et al.   Oncology Letters

Gap junctions modulate glioma invasion by direct transfer of microRNA

(2015) Xiaoting Hong et al.   Oncotarget

Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma

(2015) Jakub Mieczkowski et al.   Oncotarget

Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming

(2015) Peter J. Quesenberry et al.   Stem Cell Research & Therapy

Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

(2015) Zhe Ji et al.   eLife

RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth

(2015) Anne C. Solga et al.   NEOPLASIA

Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival

(2015) Laurent Muller et al.   OncoImmunology

Identification of a 6-Cytokine Prognostic Signature in Patients with Primary Glioblastoma Harboring M2 Microglia/Macrophage Phenotype Relevance

(2015) Jinquan Cai et al.   PLoS One

The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients

(2015) Michelle Paff et al.   Human Vaccines & Immunotherapeutics

Proinflammatory-Activated Glioma Cells Induce a Switch in Microglial Polarization and Activation Status, From a Predominant M2b Phenotype to a Mixture of M1 and M2a/B Polarized Cells

(2014) Lucia Lisi et al.   ASN Neuro

The orthotopic xenotransplant of human glioblastoma successfully recapitulates glioblastoma-microenvironment interactions in a non-immunosuppressed mouse model

(2014) Celina Garcia et al.   BMC CANCER

Epidemiologic and Molecular Prognostic Review of Glioblastoma

(2014) J. P. Thakkar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma

(2014) X. Chen et al.   CANCER RESEARCH

Tumor-Associated Macrophages in SHH Subgroup of Medulloblastomas

(2014) A. S. Margol et al.   CLINICAL CANCER RESEARCH

The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions

(2014) Kenneth L. Pitter et al.   GLIA

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

(2014) Susan P. C. Cole   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotrophin Signaling via TrkB and TrkC Receptors Promotes the Growth of Brain Tumor-initiating Cells

(2014) Samuel Lawn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p75 Neurotrophin Receptor Cleavage by α- and γ-Secretases Is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells

(2014) Peter A. Forsyth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages

(2014) Anna Carolina Carvalho da Fonseca et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of miR-142-3p on the M2 Macrophage and Therapeutic Efficacy Against Murine Glioblastoma

(2014) Shuo Xu et al.   JNCI-Journal of the National Cancer Institute

The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria

(2014) Octavio Silva-García et al.   MEDIATORS OF INFLAMMATION

Circulating glioma biomarkers

(2014) J. M. Kros et al.   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007-2011

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Chemokine expression profile of freshly isolated human glioblastoma-associated macrophages/microglia

(2014) KIRSTEN HATTERMANN et al.   ONCOLOGY REPORTS

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Transforming growth factor-beta and its implication in the malignancy of gliomas

(2014) Laurent-Olivier Roy et al.   Targeted Oncology

Review Glioblastoma multiforme – an overview

(2014) Kaja Urbańska et al.   Wspolczesna Onkologia-Contemporary Oncology

Gliomas and the vascular fragility of the blood brain barrier

(2014) Luiz Gustavo Dubois et al.   Frontiers in Cellular Neuroscience

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis

(2013) Min-Chi Ku et al.   ACTA NEUROPATHOLOGICA

BMP4 reverses multidrug resistance through modulation of BCL-2 and GDNF in glioblastoma

(2013) Baohui Liu et al.   BRAIN RESEARCH

The relevance of the TGF-β Paradox to EMT-MET programs

(2013) Chevaun D. Morrison et al.   CANCER LETTERS

Microglia and Macrophages in Malignant Gliomas: Recent Discoveries and Implications for Promising Therapies

(2013) Anna Carolina Carvalho da Fonseca et al.   Clinical & Developmental Immunology

Equinatoxin II Potentiates Temozolomide- and Etoposide-Induced Glioblastoma Cell Death

(2013) Suzana Assad Kahn et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia

(2013) Carina Halleskog et al.   JOURNAL OF NEUROCHEMISTRY

The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion

(2013) Starlee Lively et al.   Journal of Neuroinflammation

Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response

(2013) Malgorzata Sielska et al.   JOURNAL OF PATHOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats

(2013) Shie-Chau Liu et al.   NEURO-ONCOLOGY

Insights into TREM2 biology by network analysis of human brain gene expression data

(2013) Paola Forabosco et al.   NEUROBIOLOGY OF AGING

Astrocytes Enhance the Invasion Potential of Glioblastoma Stem-Like Cells

(2013) Barbara H. Rath et al.   PLoS One

miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development

(2013) Johnny C. Akers et al.   PLoS One

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

TGF-β as a therapeutic target in high grade gliomas – Promises and challenges

(2012) Justin V. Joseph et al.   BIOCHEMICAL PHARMACOLOGY

Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production

(2012) Zhi Shi et al.   BREAST CANCER RESEARCH AND TREATMENT

Interleukins in glioblastoma pathophysiology: implications for therapy

(2012) YT Yeung et al.   BRITISH JOURNAL OF PHARMACOLOGY

Isocitrate dehydrogenase 1R132H mutation in microglia/macrophages in gliomas

(2012) Ping-Pin Zheng et al.   CANCER BIOLOGY & THERAPY

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

(2012) Eugene D. Ponomarev et al.   GLIA

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

Unknown

(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

(2012) Irfan A. Qureshi et al.   NATURE REVIEWS NEUROSCIENCE

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response

(2012) Anand Iyer et al.   PLoS One

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas

(2011) D Tseng et al.   BRITISH JOURNAL OF CANCER

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

(2011) J. Zhang et al.   CARCINOGENESIS

Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment

(2011) Christopher Jackson et al.   Clinical & Developmental Immunology

An optimized protocol for the acute isolation of human microglia from autopsy brain samples

(2011) Marta Olah et al.   GLIA

Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling

(2011) Vassiliki Tzelepi et al.   HISTOPATHOLOGY

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

(2011) Ana L. Cardoso et al.   IMMUNOLOGY

Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model

(2011) Shu-Chi Wang et al.   LABORATORY INVESTIGATION

Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells

(2011) A.C.C. da Fonseca et al.   NEUROSCIENCE

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

(2011) E. Tili et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC

(2011) Claudia Quezada et al.   REVISTA MEDICA DE CHILE

Epidemiology of Brain Metastases

(2011) Lakshmi Nayak et al.   Current Oncology Reports

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

MicroRNA-155 Regulates Inflammatory Cytokine Production in Tumor-associated Macrophages via Targeting C/EBPβ

(2010) Min He et al.   Cellular & Molecular Immunology

CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs)

(2010) Janka Held-Feindt et al.   EXPERIMENTAL CELL RESEARCH

WNT signaling in activated microglia is proinflammatory

(2010) Carina Halleskog et al.   GLIA

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way

(2010) Tobias Pukrop et al.   GLIA

Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice

(2009) Leying Zhang et al.   GLIA

Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor α increases cyclooxygenase-2 expression, PGE2 release and interferon-γ-induced CD40 in murine microglia

(2009) Hsiao-Wen Lin et al.   Journal of Neuroinflammation

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+cell to Imatinib and Nilotinib

(2009) Falk Dillmann et al.   LEUKEMIA & LYMPHOMA

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

Differences in the Expression Pattern of P-Glycoprotein and MRP1 in Low-Grade and High-Grade Gliomas

(2008) Giselle Pinto de Faria et al.   CANCER INVESTIGATION

Tubulin cofactor B regulates microtubule densities during microglia transition to the reactive states

(2008) M.L. Fanarraga et al.   EXPERIMENTAL CELL RESEARCH

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