p75 Neurotrophin Receptor Cleavage by α- and γ-Secretases Is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells

ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro

(2013) J. Xiong et al.   NEURO-ONCOLOGY

A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells

(2012) Harry Bulstrode et al.   CANCER LETTERS

Neurotrophins and their receptors in breast cancer

(2012) Hubert Hondermarck   CYTOKINE & GROWTH FACTOR REVIEWS

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Krüppel-Like Factor 8 (KLF8) Is Expressed in Gliomas of Different WHO Grades and Is Essential for Tumor Cell Proliferation

(2012) Oliver Schnell et al.   PLoS One

Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells

(2011) Yi-Yang Hu et al.   BMC CANCER

Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling

(2011) Reddy P. Kommaddi et al.   FASEB JOURNAL

p75NTR expression and nuclear localization of p75NTR intracellular domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation

(2011) Matthew J. Provenzano et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Oxygen-Dependent Cleavage of the p75 Neurotrophin Receptor Triggers Stabilization of HIF-1α

(2011) Natacha Le Moan et al.   MOLECULAR CELL

Differential profiling studies of N-linked glycoproteins in glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor

(2011) Lan Dai et al.   PROTEOMICS

ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation

(2010) Xuguang Zheng et al.   CANCER BIOLOGY & THERAPY

Overexpression of p75NTR increases survival of breast cancer cells through p21waf1

(2010) Stéphanie Verbeke et al.   CELLULAR SIGNALLING

p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17

(2010) Rajappa S. Kenchappa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling

(2010) C. Ceni et al.   JOURNAL OF CELL SCIENCE

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Hypoxia Helps Glioma to Fight Therapy

(2009) Verena Amberger-Murphy   CURRENT CANCER DRUG TARGETS

Nuclear Localization of the p75 Neurotrophin Receptor Intracellular Domain

(2009) Christopher N. Parkhurst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM-10-Mediated N-Cadherin Cleavage Is Protein Kinase C-  Dependent and Promotes Glioblastoma Cell Migration

(2009) Z. A. Kohutek et al.   JOURNAL OF NEUROSCIENCE

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells

(2009) G. L. Gallia et al.   MOLECULAR CANCER THERAPEUTICS

Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers

(2009) Marçal Vilar et al.   NEURON

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

TrkA overexpression enhances growth and metastasis of breast cancer cells

(2009) C Lagadec et al.   ONCOGENE

Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival

(2009) A Sarangi et al.   ONCOGENE

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo

(2008) M J M Bertrand et al.   CELL DEATH AND DIFFERENTIATION

An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours

(2008) Talal M. Fael Al-Mayhani et al.   JOURNAL OF NEUROSCIENCE METHODS

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition

(2008) Christine E. Eyler et al.   STEM CELLS

SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

(2008) Rosaria Maria Rita Gangemi et al.   STEM CELLS

Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor

(2008) LiMei Wang et al.   PLOS BIOLOGY