IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression

The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities

(2015) Daniel J. Silver et al.   NEURO-ONCOLOGY

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells

(2015) Elena Ciaglia et al.   Oncotarget

Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma

(2015) Serena Pellegatta et al.   Acta Neuropathologica Communications

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

(2015) Sevin Turcan et al.   Oncotarget

MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape

(2015) Paula Codo et al.   Oncotarget

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition

(2014) A. Kernytsky et al.   BLOOD

Induction of Robust Type-I CD8+ T-cell Responses in WHO Grade 2 Low-Grade Glioma Patients Receiving Peptide-Based Vaccines in Combination with Poly-ICLC

(2014) H. Okada et al.   CLINICAL CANCER RESEARCH

Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia

(2014) A Baragaño Raneros et al.   GENES AND IMMUNITY

A vaccine targeting mutant IDH1 induces antitumour immunity

(2014) Theresa Schumacher et al.   NATURE

Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients

(2014) C. A. Crane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

(2013) J.-A. Losman et al.   SCIENCE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study

(2012) Esther M de Kruijf et al.   BMC CANCER

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition

(2011) E. Mamessier et al.   CANCER RESEARCH

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients

(2010) T. Di Tomaso et al.   CLINICAL CANCER RESEARCH

Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer

(2010) Xiaohui Duan et al.   MEDICAL ONCOLOGY

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

(2009) Takuya Watanabe et al.   AMERICAN JOURNAL OF PATHOLOGY

NKG2D Ligand Expression in Human Colorectal Cancer Reveals Associations with Prognosis and Evidence for Immunoediting

(2009) R. W. McGilvray et al.   CLINICAL CANCER RESEARCH

The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins†

(2008) Margot G. Paulick et al.   BIOCHEMISTRY

NKG2D ligands in tumor immunity

(2008) N Nausch et al.   ONCOGENE

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance

(2008) A. M. Unni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA