Regulatory Roles of Long Non-Coding RNAs in the Central Nervous System and Associated Neurodegenerative Diseases

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

(2016) Sungyul Lee et al.   CELL

Mechanisms of long noncoding RNA function in development and disease

(2016) Sandra U. Schmitz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Long Noncoding RNAs Regulate Cell Growth, Proliferation, and Apoptosis

(2016) Jingqiu Li et al.   DNA AND CELL BIOLOGY

Long non-coding RNAs: An emerging powerhouse in the battle between life and death of tumor cells

(2016) Xing-dong Xiong et al.   DRUG RESISTANCE UPDATES

Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression

(2016) Roland Elling et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Long noncoding RNAs: Central to nervous system development

(2016) Ronald P. Hart et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Unique features of long non-coding RNA biogenesis and function

(2016) Jeffrey J. Quinn et al.   NATURE REVIEWS GENETICS

A Primate lncRNA Mediates Notch Signaling during Neuronal Development by Sequestering miRNA

(2016) Neha Rani et al.   NEURON

Circular RNAs in monkey muscle: age-dependent changes

(2015) Kotb Abdelmohsen et al.   Aging-US

Diagnostic and therapeutic potentials of exosomes in CNS diseases

(2015) Ivana Kawikova et al.   BRAIN RESEARCH

The Long Noncoding RNA Pnky Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells

(2015) Alexander D. Ramos et al.   Cell Stem Cell

Long non‐coding RNAs in corticogenesis: deciphering the non‐coding code of the brain

(2015) Julieta Aprea et al.   EMBO JOURNAL

LncRNAs: emerging players in gene regulation and disease pathogenesis

(2015) MINA KAZEMZADEH et al.   JOURNAL OF GENETICS

The double-edged sword of long non-coding RNA: The role of human brain-specific BC200 RNA in translational control, neurodegenerative diseases, and cancer

(2015) Patrycja Sosińska et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature

(2015) Inma Gonzalez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long noncoding RNAs in TDP-43 and FUS/TLS-related frontotemporal lobar degeneration (FTLD)

(2015) Guinevere F. Lourenco et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of Long Non-coding RNAs in Mammalian Nervous System Development, Plasticity, Disease, and Evolution

(2015) James A. Briggs et al.   NEURON

DeCoN: Genome-wide Analysis of In Vivo Transcriptional Dynamics during Pyramidal Neuron Fate Selection in Neocortex

(2015) Bradley J. Molyneaux et al.   NEURON

PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNAPCA3

(2015) Ahmad Salameh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome analyses of adult mouse brain reveal enrichment of lncRNAs in specific brain regions and neuronal populations

(2015) Beena M. Kadakkuzha et al.   Frontiers in Cellular Neuroscience

A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature

(2015) Inma Gonzalez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway

(2015) Feng Wang et al.   Oncotarget

The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression

(2015) Wei Jiang et al.   Cell Reports

Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

(2015) Zhe Ji et al.   eLife

Pseudogene-derived lncRNAs: emerging regulators of gene expression

(2015) Michael J. Milligan et al.   Frontiers in Genetics

Natural Antisense Transcript: A Concomitant Engagement with Protein-Coding Transcript

(2015)   Oncotarget

lncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals

(2014) Zhen Xing et al.   CELL

Biogenesis of Circular RNAs

(2014) Quentin Vicens et al.   CELL

The long non-coding RNA Paupar regulates the expression of both local and distal genes

(2014) K. W. Vance et al.   EMBO JOURNAL

LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b

(2014) Yuan Gao et al.   HUMAN MOLECULAR GENETICS

An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment

(2014) Nianwei Lin et al.   MOLECULAR CELL

A promoter-level mammalian expression atlas

(2014)   NATURE

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease

(2014) T. C. Roberts et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases

(2014) Ronald Gstir et al.   RNA

The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

(2014) P. Wang et al.   SCIENCE

Transcriptional regulatory functions of nuclear long noncoding RNAs

(2014) Keith W. Vance et al.   TRENDS IN GENETICS

Considerations when investigating lncRNA function in vivo

(2014) Andrew R Bassett et al.   eLife

The long non-coding RNA Dali is an epigenetic regulator of neural differentiation

(2014) Vladislava Chalei et al.   eLife

Long non-coding RNAs learn the importance of being in vivo

(2014) Jhumku D. Kohtz   Frontiers in Genetics

Molecular mechanisms of long ncRNAs in neurological disorders

(2014) Dubravka Vučićević et al.   Frontiers in Genetics

Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases

(2013) Ping Wu et al.   BRAIN RESEARCH BULLETIN

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

(2013) Mark Katakowski et al.   CANCER LETTERS

Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding

(2013) Aleksandra Helwak et al.   CELL

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

(2013) Pedro J. Batista et al.   CELL

lincRNAs: Genomics, Evolution, and Mechanisms

(2013) Igor Ulitsky et al.   CELL

Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment

(2013) Carla A. Klattenhoff et al.   CELL

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

(2013) Albert W Cheng et al.   CELL RESEARCH

Integration of Genome-wide Approaches Identifies lncRNAs of Adult Neural Stem Cells and Their Progeny In Vivo

(2013) Alexander D. Ramos et al.   Cell Stem Cell

Developmental Changes in the Transcriptome of Human Cerebral Cortex Tissue: Long Noncoding RNA Transcripts

(2013) Leonard Lipovich et al.   CEREBRAL CORTEX

Long non-coding RNAs: modulators of nuclear structure and function

(2013) Jan H Bergmann et al.   CURRENT OPINION IN CELL BIOLOGY

The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse

(2013) Phillip Grote et al.   DEVELOPMENTAL CELL

Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment

(2013) Julieta Aprea et al.   EMBO JOURNAL

Long Noncoding RNAs: Past, Present, and Future

(2013) J. T. Y. Kung et al.   GENETICS

MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas

(2013) Vladimir Balik et al.   JOURNAL OF NEURO-ONCOLOGY

iCLIP: Protein–RNA interactions at nucleotide resolution

(2013) Ina Huppertz et al.   METHODS

The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis

(2013) Shi-Yan Ng et al.   MOLECULAR CELL

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Long Non-coding RNAs: Novel Targets for Nervous System Disease Diagnosis and Therapy

(2013) Irfan A. Qureshi et al.   Neurotherapeutics

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

(2013) T. Zu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The long non-coding RNAFendrrlinks epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis

(2013) Phillip Grote et al.   RNA Biology

The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis

(2013) Yoshinori Nishimoto et al.   Molecular Brain

The Vast, Conserved Mammalian lincRNome

(2013) David Managadze et al.   PLoS Computational Biology

Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs

(2013) Aurélie Kapusta et al.   PLoS Genetics

Circular RNA (circRNA) in Alzheimer's disease (AD)

(2013) Walter J. Lukiw   Frontiers in Genetics

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations

(2012) S. F. Pinter et al.   GENOME RESEARCH

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

(2012) Claudia Carrieri et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

(2012) Farzaneh Modarresi et al.   NATURE BIOTECHNOLOGY

Combined RNAi and localization for functionally dissecting long noncoding RNAs

(2012) Debojyoti Chakraborty et al.   NATURE METHODS

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

(2012) Irfan A. Qureshi et al.   NATURE REVIEWS NEUROSCIENCE

Exosome nanotechnology: An emerging paradigm shift in drug delivery

(2011) Samira Lakhal et al.   BIOESSAYS

The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA

(2011) Philipp Kapranov et al.   BMC BIOLOGY

Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors

(2011) Shi-Yan Ng et al.   EMBO JOURNAL

A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expression

(2011) Daniel W. Chung et al.   HUMAN MOLECULAR GENETICS

Identification of Novel GDNF Isoforms andcis-Antisense GDNFOS Gene and Their Regulation in Human Middle Temporal Gyrus of Alzheimer Disease

(2011) Mikko Airavaara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

lincRNAs act in the circuitry controlling pluripotency and differentiation

(2011) Mitchell Guttman et al.   NATURE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation

(2010) Di Tian et al.   CELL

Emerging Roles for Natural MicroRNA Sponges

(2010) Margaret S. Ebert et al.   CURRENT BIOLOGY

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression

(2010) Delphine Bernard et al.   EMBO JOURNAL

Altered microRNA regulation in Huntington's disease models

(2010) Soon-Tae Lee et al.   EXPERIMENTAL NEUROLOGY

Origins, evolution, and phenotypic impact of new genes

(2010) H. Kaessmann   GENOME RESEARCH

Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region

(2010) Corinne Chureau et al.   HUMAN MOLECULAR GENETICS

17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease

(2010) Sara Massone et al.   NEUROBIOLOGY OF DISEASE

Evolution and Functions of Long Noncoding RNAs

(2009) Chris P. Ponting et al.   CELL

Characterization of Alternative Isoforms and Inclusion Body of the TAR DNA-binding Protein-43

(2009) Yoshinori Nishimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BC1 Regulation of Metabotropic Glutamate Receptor-Mediated Neuronal Excitability

(2009) J. Zhong et al.   JOURNAL OF NEUROSCIENCE

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry

(2009) Allison M Bond et al.   NATURE NEUROSCIENCE

Genomic and Transcriptional Co-Localization of Protein-Coding and Long Non-Coding RNA Pairs in the Developing Brain

(2009) Jasmina Ponjavic et al.   PLoS Genetics

SYNCRIP, a component of dendritically localized mRNPs, binds to the translation regulator BC200 RNA

(2008) Kerstin Duning et al.   JOURNAL OF NEUROCHEMISTRY

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE

Specific expression of long noncoding RNAs in the mouse brain

(2008) T. R. Mercer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA