Reactive Astrocytes in Glioblastoma Multiforme

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement

(2016) Rashmi Bharti et al.   CANCER LETTERS

CGCG clinical practice guidelines for the management of adult diffuse gliomas

(2016) Tao Jiang et al.   CANCER LETTERS

Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+exchanger isoform 1

(2016) Wen Zhu et al.   CARCINOGENESIS

Astrocyte roles in traumatic brain injury

(2016) Joshua E. Burda et al.   EXPERIMENTAL NEUROLOGY

Temozolomide induces the expression of the glioma Big Potassium (gBK) ion channel, while inhibiting fascin-1 expression: possible targets for glioma therapy

(2016) Neil T. Hoa et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases

(2016) Israel Hanukoglu et al.   GENE

Glial Na+-dependent ion transporters in pathophysiological conditions

(2016) Francesca Boscia et al.   GLIA

Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples

(2016) Frank Szulzewsky et al.   GLIA

Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+and Zn2+: role of TRPM2 channels

(2016) Fangfang Li et al.   JOURNAL OF CELL SCIENCE

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model

(2016) Onyinyechukwu Okolie et al.   NEURO-ONCOLOGY

Reactive astrocytes and therapeutic potential in focal ischemic stroke

(2016) Gourav Roy Choudhury et al.   NEUROBIOLOGY OF DISEASE

Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14

(2016) Weiliang Chen et al.   Oncotarget

DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways

(2016) Meijuan Zou et al.   Scientific Reports

Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance

(2016) Alessia Fidoamore et al.   Stem Cells International

Glioma Stem Cells: Signaling, Microenvironment, and Therapy

(2016) Brandon D. Liebelt et al.   Stem Cells International

Progress in the application of molecular biomarkers in gliomas

(2015) Jing Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets

(2015) Marta Peretti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Analysis of the expression of Kv10.1 potassium channel in patients with brain metastases and glioblastoma multiforme: impact on survival

(2015) Ramón Martínez et al.   BMC CANCER

Increase in the extracellular glutamate level during seizures and electrical stimulation determined using a high temporal resolution technique

(2015) Laura Medina-Ceja et al.   BMC NEUROSCIENCE

Nonsurgical treatment of recurrent glioblastoma

(2015) O. Gallego   Current Oncology

Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines

(2015) Edmund Cheung So et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling

(2015) M. L. Olsen et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes

(2015) Weiliang Chen et al.   MEDICAL ONCOLOGY

Ca2+-Activated IK K+ Channel Blockade Radiosensitizes Glioblastoma Cells

(2015) B. Stegen et al.   MOLECULAR CANCER RESEARCH

Astrocytes protect glioma cells from chemotherapy and upregulate survival genes via gap junctional communication

(2015) QINGTANG LIN et al.   Molecular Medicine Reports

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Astrocytes promote glioma invasion via the gap junction protein connexin43

(2015) W C Sin et al.   ONCOGENE

Gene expressions of TRP channels in glioblastoma multiforme and relation with survival

(2015) M. Alptekin et al.   TUMOR BIOLOGY

The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment

(2015) Amanda L. Placone et al.   TUMOR BIOLOGY

The role of ion channels in the hypoxia-induced aggressiveness of glioblastoma

(2015) Luigi Sforna et al.   Frontiers in Cellular Neuroscience

Tunneling nanotubes between rat primary astrocytes and C6 glioma cells alter proliferation potential of glioma cells

(2015) Lei Zhang et al.   Neuroscience Bulletin

Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion

(2015) Wen-Liang Chen et al.   Oncotarget

Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo

(2015) Michaela Nelson et al.   Oncotarget

Gap junctions modulate glioma invasion by direct transfer of microRNA

(2015) Xiaoting Hong et al.   Oncotarget

Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth

(2015) Matteo Setti et al.   Oncotarget

Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

(2015) Carrie D. House et al.   Scientific Reports

Coculture with astrocytes reduces the radiosensitivity of glioblastoma stem-like cells and identifies additional targets for radiosensitization

(2015) Barbara H. Rath et al.   Cancer Medicine

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

(2015) Marta Gritti et al.   Oncotarget

Tumoral RANKL activates astrocytes that promote glioma cell invasion through cytokine signaling

(2014) Jun-Kyum Kim et al.   CANCER LETTERS

Astrocyte Elevated Gene-1 Interacts with Akt Isoform 2 to Control Glioma Growth, Survival, and Pathogenesis

(2014) B. Hu et al.   CANCER RESEARCH

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+extrusion, cell migration and survival

(2014) Damin Cong et al.   CARCINOGENESIS

TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways

(2014) Mingli Liu et al.   CELLULAR SIGNALLING

Suppression of TRPM7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells

(2014) Tian-Dong Leng et al.   CNS Neuroscience & Therapeutics

Neurotransmitter signaling in white matter

(2014) Arthur M. Butt et al.   GLIA

Myelination, oligodendrocytes, and serious mental illness

(2014) V. Haroutunian et al.   GLIA

The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution

(2014) Suzana Herculano-Houzel   GLIA

A proinvasive role for the Ca2+-activated K+channel KCa3.1 in malignant glioma

(2014) Kathryn L. Turner et al.   GLIA

Paracrine regulation of glioma cells invasion by astrocytes is mediated by glial-derived neurotrophic factor

(2014) Ayelet Shabtay-Orbach et al.   INTERNATIONAL JOURNAL OF CANCER

MiR-133b Contributes to Arsenic-Induced Apoptosis in U251 Glioma Cells by Targeting the hERG Channel

(2014) Jian Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Low-voltage-activated T-type Ca2+ channel inhibitors as new tools in the treatment of glioblastoma: the role of endostatin

(2014) Yuan Zhang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

What do we know about gliotransmitter release from astrocytes?

(2014) D. A. Sahlender et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

(2014) Milos Pekny et al.   PHYSIOLOGICAL REVIEWS

Herg K+ Channel-Dependent Apoptosis and Cell Cycle Arrest in Human Glioblastoma Cells

(2014) Ingo Staudacher et al.   PLoS One

Semapimod Sensitizes Glioblastoma Tumors to Ionizing Radiation by Targeting Microglia

(2014) Ian S. Miller et al.   PLoS One

The aggregation of mutant p53 produces prion-like properties in cancer

(2014) Luciana P Rangel et al.   Prion

Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

(2014) J L Munoz et al.   Cell Death & Disease

Glioblastoma cells inhibit astrocytic p53-expression favoring cancer malignancy

(2014) D Biasoli et al.   Oncogenesis

Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells

(2013) Nicholas C.K. Valerie et al.   BIOCHEMICAL PHARMACOLOGY

Functional Role of CLIC1 Ion Channel in Glioblastoma-Derived Stem/Progenitor Cells

(2013) Matteo Setti et al.   JNCI-Journal of the National Cancer Institute

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Store-Operated Ca2+ Channels Blockers Inhibit Lipopolysaccharide Induced Astrocyte Activation

(2013) Jian-Hua Li et al.   NEUROCHEMICAL RESEARCH

Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway

(2013) Paul R. Gielen et al.   NEUROPHARMACOLOGY

Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme

(2013) XU SUN et al.   ONCOLOGY REPORTS

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

(2013) Rajender K. Motiani et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity

(2013) M Bury et al.   Cell Death & Disease

Inhibition of T-type Ca2+ channels by endostatin attenuates human glioblastoma cell proliferation and migration

(2012) Yuan Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Na+-K+-2Cl–Cotransporter isoform 1 Accelerates Temozolomidemediated Apoptosis in Glioblastoma Cancer Cells

(2012) Jehad Algharabil et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-à-go-go (EAG1)

(2012) Yifeng Bai et al.   EUROPEAN JOURNAL OF CANCER

Real-time multi-modality imaging of glioblastoma tumor resection and recurrence

(2012) Shawn Hingtgen et al.   JOURNAL OF NEURO-ONCOLOGY

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

(2012) Kristin Stock et al.   NATURE MEDICINE

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

Role of Gap Junction Protein Connexin43 in Astrogliosis Induced by Brain Injury

(2012) Nicolas Theodoric et al.   PLoS One

Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes

(2011) Niren Kapoor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)

(2011) Lyle W. Ostrow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential expression of a novel voltage gated potassium channel – Kv 1.5 in astrocytomas and its impact on prognosis in glioblastoma

(2011) S. Arvind et al.   BRITISH JOURNAL OF NEUROSURGERY

Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis

(2011) Huiling Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Glioma-specific Cation Conductance Regulates Migration and Cell Cycle Progression

(2011) Arun K. Rooj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium ion channel mutations in glioblastoma patients correlate with shorter survival

(2011) Avadhut D Joshi et al.   Molecular Cancer

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

CXCL12-induced glioblastoma cell migration requires intermediate conductance Ca2+-activated K+ channel activity

(2010) Miriam Sciaccaluga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival

(2010) S. S. Kang et al.   CANCER RESEARCH

Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas

(2010) Valerie C. Bomben et al.   GLIA

Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas

(2010) Valerie C. Bomben et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Serum-activated K and Cl currents underlay U87-MG glioblastoma cell migration

(2010) Luigi Catacuzzeno et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1

(2010) Li   ONCOLOGY REPORTS

Temozolomide in malignant gliomas: current use and future targets

(2009) J. Lee Villano et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Receptor Channel TRPC6 Is a Key Mediator of Notch-Driven Glioblastoma Growth and Invasiveness

(2009) S. Chigurupati et al.   CANCER RESEARCH

Knockdown of ASIC1 and Epithelial Sodium Channel Subunits Inhibits Glioblastoma Whole Cell Current and Cell Migration

(2009) Niren Kapoor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model

(2009) Gagliano   ONCOLOGY REPORTS

HGF/SF and menthol increase human glioblastoma cell calcium and migration

(2008) Robert Wondergem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Basis of Nuclear Factor- B Activation by Astrocyte Elevated Gene-1

(2008) D. Sarkar et al.   CANCER RESEARCH

Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IκBα-NF-κB signaling pathway

(2008) Shu-Ting Lin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

New developments in the signaling mechanisms of the store-operated calcium entry pathway

(2008) Marie Potier et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY