Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
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Title
Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
Authors
Keywords
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Journal
BLOOD
Volume 115, Issue 18, Pages 3817-3826
Publisher
American Society of Hematology
Online
2010-03-04
DOI
10.1182/blood-2009-05-224808
References
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Related references
Note: Only part of the references are listed.- A genome-wide association analysis of serum iron concentrations
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- BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
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- Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
- (2008) L. Kautz et al. BLOOD
- Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency
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- RETRACTED: The Hepcidin-Binding Site on Ferroportin Is Evolutionarily Conserved
- (2008) Ivana De Domenico et al. Cell Metabolism
- The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression
- (2008) Paul J. Schmidt et al. Cell Metabolism
- The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin
- (2008) Laura Silvestri et al. Cell Metabolism
- A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
- (2008) M. A. Melis et al. HAEMATOLOGICA
- Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
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- The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
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- Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
- (2007) L. Silvestri et al. BLOOD
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