Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin

(2008) Robin Kuns-Hashimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neogenin Interacts with Hemojuvelin through Its Two Membrane-Proximal Fibronectin Type III Domains†

(2008) Fan Yang et al.   BIOCHEMISTRY

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

(2008) J. E. Maxson et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Neogenin-mediated Hemojuvelin Shedding Occurs after Hemojuvelin Traffics to the Plasma Membrane

(2008) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin

(2008) Gregor Schaffar et al.   JOURNAL OF NEUROCHEMISTRY

The Neogenin Intracellular Domain Regulates Gene Transcription via Nuclear Translocation

(2008) D. Goldschneider et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD

Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site

(2007) Lan Lin et al.   BLOOD CELLS MOLECULES AND DISEASES

Regulation of iron acquisition and storage: consequences for iron-linked disorders

(2007) Ivana De Domenico et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY