An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine -thalassemia intermedia
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Title
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine -thalassemia intermedia
Authors
Keywords
-
Journal
BLOOD
Volume 121, Issue 7, Pages 1200-1208
Publisher
American Society of Hematology
Online
2012-12-07
DOI
10.1182/blood-2012-09-453977
References
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Related references
Note: Only part of the references are listed.- Safety profile of RNAi nanomedicines
- (2012) Scott A. Barros et al. ADVANCED DRUG DELIVERY REVIEWS
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- (2012) E. Khandros et al. BLOOD
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- (2012) W. Querbes et al. BLOOD
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- (2012) A. Nai et al. BLOOD
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- (2011) D.-L. Zhang et al. BLOOD
- -thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism
- (2011) Y. Ginzburg et al. BLOOD
- Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice
- (2011) K. E. Finberg et al. BLOOD
- TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals
- (2011) A. Nai et al. BLOOD
- Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia
- (2011) Tsutomu Sato et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
- (2011) Gloria C. Preza et al. JOURNAL OF CLINICAL INVESTIGATION
- A novel mutation Gly603Arg of TMPRSS6 in a Korean female with iron-refractory iron deficiency anemia
- (2011) Hyoung Soo Choi et al. PEDIATRIC BLOOD & CANCER
- Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
- (2010) K. E. Finberg et al. BLOOD
- Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin
- (2010) P. J. Schmidt et al. BLOOD
- Cryptic splice site usage leading to truncated TMPRSS6 is responsible for iron refractory iron deficiency anaemia in an Italian Family
- (2010) Tchou Isabelle et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
- (2010) Sara Gardenghi et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- Rational design of cationic lipids for siRNA delivery
- (2010) Sean C Semple et al. NATURE BIOTECHNOLOGY
- Transferrin therapy ameliorates disease in β-thalassemic mice
- (2010) Huihui Li et al. NATURE MEDICINE
- Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
- (2008) A. R. Folgueras et al. BLOOD
- Hfe Acts in Hepatocytes to Prevent Hemochromatosis
- (2008) Maja Vujić Spasić et al. Cell Metabolism
- The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin
- (2008) Laura Silvestri et al. Cell Metabolism
- A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
- (2008) M. A. Melis et al. HAEMATOLOGICA
- Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
- (2008) Karin E Finberg et al. NATURE GENETICS
- Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
- (2008) M. Frank-Kamenetsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
- (2008) X. Du et al. SCIENCE
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