Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase

(2017) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcription factorPax6is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+dynamics in adult mice

(2017) Ryan K. Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?

(2017) Katleen Lemaire et al.   PLoS One

Combination SGLT2 inhibitor and GLP-1 receptor agonist therapy: a complementary approach to the treatment of type 2 diabetes

(2017) Robert S. Busch et al.   POSTGRADUATE MEDICINE

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

(2017) A. S. Axelsson et al.   Nature Communications

Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene

(2017) Timothy J. Pullen et al.   Frontiers in Genetics

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell

(2017) Jones K. Ofori et al.   Scientific Reports

The Role of Inflammation in β-cell Dedifferentiation

(2017) Thierry M. Nordmann et al.   Scientific Reports

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

(2016) Katleen Lemaire et al.   Annual Review of Nutrition

Zinc and diabetes

(2016) Pauline Chabosseau et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice

(2016) Seizo Okauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disallowance ofAcot7in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion

(2016) Aida Martinez-Sanchez et al.   DIABETES

A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?

(2016) Terence P. Herbert et al.   DIABETES

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells

(2016) Mohammed Bensellam et al.   DIABETOLOGIA

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

(2016) Ting Zhang et al.   ENDOCRINOLOGY

Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma

(2016) Alexander Roesch et al.   EUROPEAN JOURNAL OF CANCER

ALDH1A3, a metabolic target for cancer diagnosis and therapy

(2016) Jiang-Jie Duan et al.   INTERNATIONAL JOURNAL OF CANCER

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic β cell identity requires continual repression of non–β cell programs

(2016) Giselle Domínguez Gutiérrez et al.   JOURNAL OF CLINICAL INVESTIGATION

LIM domain–binding 1 maintains the terminally differentiated state of pancreatic β cells

(2016) Benjamin N. Ediger et al.   JOURNAL OF CLINICAL INVESTIGATION

PAX6 maintains β cell identity by repressing genes of alternative islet cell types

(2016) Avital Swisa et al.   JOURNAL OF CLINICAL INVESTIGATION

Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance

(2016) Fengsheng Li et al.   Oncology Letters

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

(2016) Ja Young Kim-Muller et al.   Nature Communications

Beneficial effects of sodium-glucose cotransporter 2 inhibitors for preservation of pancreatic β -cell function and reduction of insulin resistance

(2016) Hideaki Kaneto et al.   Journal of Diabetes

Reversibility ofβ-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse

(2016) Chunjun Sheng et al.   Journal of Diabetes Research

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

Stress induces cell dedifferentiation in plants

(2015) Gideon Grafi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis

(2015) Jaeseok Han et al.   DIABETES

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

(2015) Cristina Alarcon et al.   DIABETES

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

(2015) H. Siebe Spijker et al.   DIABETES

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells

(2015) Mohammed Bensellam et al.   DIABETOLOGIA

Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models

(2015) Fang Chen et al.   DIABETOLOGIA

DNA methylation directs functional maturation of pancreatic β cells

(2015) Sangeeta Dhawan et al.   JOURNAL OF CLINICAL INVESTIGATION

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

(2015) Mourad Ferdaoussi et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo

(2015) Quanlu Duan et al.   Journal of Translational Medicine

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

(2015) Jeng Yie Chan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

DICER Inactivation Identifies Pancreatic β-Cell “Disallowed” Genes Targeted by MicroRNAs

(2015) Aida Martinez-Sanchez et al.   MOLECULAR ENDOCRINOLOGY

The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

(2015) Bengt-Frederik Belgardt et al.   NATURE MEDICINE

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity

(2015) Suneng Fu et al.   Science Translational Medicine

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

(2015) Cécile Jacovetti et al.   Nature Communications

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

(2015) Justin R. Hassler et al.   PLOS BIOLOGY

MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion

(2014) Guido Sebastiani et al.   ACTA DIABETOLOGICA

Absence of BiP Co-chaperone DNAJC3 Causes Diabetes Mellitus and Multisystemic Neurodegeneration

(2014) Matthis Synofzik et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice

(2014) Ja Young Kim-Muller et al.   Cell Metabolism

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells

(2014) Tongfu Xu et al.   CELL RESEARCH

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet

(2014) J. Molina et al.   DIABETES

Effect of hyperglycaemia on muscarinic M3 receptor expression and secretory sensitivity to cholinergic receptor activation in islets

(2014) A. C. Hauge-Evans et al.   DIABETES OBESITY & METABOLISM

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells

(2014) Oanh H. Do et al.   DIABETOLOGIA

GLUT2, glucose sensing and glucose homeostasis

(2014) Bernard Thorens   DIABETOLOGIA

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

TRIB3 alters endoplasmic reticulum stress-induced β-cell apoptosis via the NF-κB pathway

(2014) Ni Fang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

ID Proteins Regulate Diverse Aspects of Cancer Progression and Provide Novel Therapeutic Opportunities

(2014) Radhika Nair et al.   MOLECULAR THERAPY

Moderate Hypoxia Induces β-Cell Dysfunction with HIF-1–Independent Gene Expression Changes

(2014) Yoshifumi Sato et al.   PLoS One

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Aberrant islet unfolded protein response in type 2 diabetes

(2014) Feyza Engin et al.   Scientific Reports

Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

(2014) Julie Piccand et al.   Cell Reports

De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

(2014) Catherine A. Del Vecchio et al.   PLOS BIOLOGY

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

(2014) Barak Blum et al.   eLife

Coupling Heme and Iron Metabolism via Ferritin H Chain

(2013) Raffaella Gozzelino et al.   ANTIOXIDANTS & REDOX SIGNALING

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

(2013) Elin Hall et al.   BMC Medical Genetics

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves  -Cell Mass and Function in ZDF Rats

(2013) J. Mahadevan et al.   DIABETES

Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction

(2013) M. Sasaki et al.   DIABETES

Conversion of Mature Human  -Cells Into Glucagon-Producing  -Cells

(2013) H. S. Spijker et al.   DIABETES

miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models

(2013) J.-W. Kim et al.   DIABETOLOGIA

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion

(2013) J. M. Locke et al.   DIABETOLOGIA

Are we overestimating the loss of beta cells in type 2 diabetes?

(2013) Lorella Marselli et al.   DIABETOLOGIA

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

(2013) Valeria Nesca et al.   DIABETOLOGIA

Control of Cell Identity in Pancreas Development and Regeneration

(2013) Ben Z. Stanger et al.   GASTROENTEROLOGY

VHL-mediated disruption of Sox9 activity compromises  -cell identity and results in diabetes mellitus

(2013) S. Puri et al.   GENES & DEVELOPMENT

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets

(2013) Stacey N Walters et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Functional characteristics of neonatal rat β cells with distinct markers

(2013) G A Martens et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Thioredoxin-interacting protein regulates insulin transcription through microRNA-204

(2013) Guanlan Xu et al.   NATURE MEDICINE

The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

(2013) Tadahiro Kitamura   Nature Reviews Endocrinology

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

β-cell dedifferentiation in diabetes is important, but what is it?

(2013) Gordon C Weir et al.   Islets

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes

(2013) O Omikorede et al.   Nutrition & Diabetes

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

(2013) Ashleigh E. Schaffer et al.   PLoS Genetics

Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes

(2012) Matilde Masini et al.   ACTA DIABETOLOGICA

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

(2012) Jalal Taneera et al.   Cell Metabolism

Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic  -Cells Leads to Relative Hyperinsulinism During Exercise

(2012) T. J. Pullen et al.   DIABETES

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in  -Cell Gene Expression and Progression to Diabetes

(2012) J. Y. Chan et al.   DIABETES

β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?

(2012) Frans Schuit et al.   DIABETES

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

(2012) C. Tang et al.   DIABETOLOGIA

Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice

(2012) N. Shojima et al.   DIABETOLOGIA

MicroRNA-30d Induces Insulin Transcription Factor MafA and Insulin Production by Targeting Mitogen-activated Protein 4 Kinase 4 (MAP4K4) in Pancreatic β-Cells

(2012) Xiaomin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

(2012) Mohammed Bensellam et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin–proteasome system in pancreatic beta cell dysfunction

(2012) Marco Bugliani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes

(2012) Beatrice T. Yang et al.   MOLECULAR ENDOCRINOLOGY

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

(2012) Mohammed Bensellam et al.   PLoS One

Proinsulin Atypical Maturation and Disposal Induces Extensive Defects in Mouse Ins2+/Akita β-Cells

(2012) Qingxin Yuan et al.   PLoS One

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1

(2011) Leticia P. Roma et al.   BIOCHEMICAL JOURNAL

Deciphering c-MYC-regulated genes in two distinct tissues

(2011) Samuel C Robson et al.   BMC GENOMICS

Inhibition of Id1 Augments Insulin Secretion and Protects Against High-Fat Diet-Induced Glucose Intolerance

(2011) M. C. Akerfeldt et al.   DIABETES

Historical Perspective: Beginnings of the  -Cell: Current Perspectives in  -Cell Development

(2011) P. A. Seymour et al.   DIABETES

The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells

(2011) Jean-Claude Henquin   DIABETES RESEARCH AND CLINICAL PRACTICE

Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway

(2011) A. Lombardi et al.   DIABETOLOGIA

Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells

(2011) A. Jermendy et al.   DIABETOLOGIA

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

(2011) J. Y. Chan et al.   DIABETOLOGIA

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

(2011) Tal Melkman-Zehavi et al.   EMBO JOURNAL

Glucose-Dependent Changes in SNARE Protein Levels in Pancreatic β-Cells

(2011) Benjamín Torrejón-Escribano et al.   ENDOCRINOLOGY

Reactive oxygen species are produced at low glucose and contribute to the activation of AMPK in insulin-secreting cells

(2011) Alexandre Sarre et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cellular Hypoxia of Pancreatic β-Cells Due to High Levels of Oxygen Consumption for Insulin Secretionin Vitro

(2011) Yoshifumi Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-29a and miR-29b Contribute to Pancreatic  -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)

(2011) T. J. Pullen et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential Glucose-Regulation of MicroRNAs in Pancreatic Islets of Non-Obese Type 2 Diabetes Model Goto-Kakizaki Rat

(2011) Jonathan Lou S. Esguerra et al.   PLoS One

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes

(2011) M Szabat et al.   Cell Death & Disease

Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: Knockdown of SCOT inhibits insulin release in rat insulinoma cells

(2010) Noaman M. Hasan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cellular Plasticity within the Pancreas— Lessons Learned from Development

(2010) Sapna Puri et al.   DEVELOPMENTAL CELL

Regulation of MafA Expression in Pancreatic  -Cells in db/db Mice With Diabetes

(2010) T.-a. Matsuoka et al.   DIABETES

MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression

(2010) Liang-Liang Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis

(2010) F. Allagnat et al.   DIABETOLOGIA

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure

(2010) O. Kluth et al.   DIABETOLOGIA

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation

(2010) L. Thorrez et al.   GENOME RESEARCH

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cells

(2010) Chong Wee Liew et al.   JOURNAL OF CLINICAL INVESTIGATION

PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

(2010) Claire E. Moore et al.   MOLECULAR ENDOCRINOLOGY

Wolcott-Rallison syndrome

(2010) Cécile Julier et al.   Orphanet Journal of Rare Diseases

High Glucose Suppresses Human Islet Insulin Biosynthesis by Inducing miR-133a Leading to Decreased Polypyrimidine Tract Binding Protein-Expression

(2010) Rikard G. Fred et al.   PLoS One

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Identification of genes selectively disallowed in the pancreatic islet

(2010) Timothy J. Pullen et al.   Islets

Diabetic GK/Par rat β-cells are spontaneously protected against H2O2-triggered apoptosis. A cAMP-dependent adaptive response

(2009) Grégory Lacraz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of fructosamine-3-kinase deficiency on function and survival of mouse pancreatic islets after prolonged culture in high glucose or ribose concentrations

(2009) S. M. A. Pascal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

Beneficial effects of K-ATP channel openers in diabetes: an update on mechanisms and clinical experiences

(2009) V. Grill et al.   DIABETES OBESITY & METABOLISM

Glucose regulation of islet stress responses and β-cell failure in type 2 diabetes

(2009) J. C. Jonas et al.   DIABETES OBESITY & METABOLISM

Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

(2009) M. J. MacDonald et al.   DIABETOLOGIA

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations

(2009) M. Bensellam et al.   DIABETOLOGIA

β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes indb/dbMice

(2009) Jamie S. Harmon et al.   ENDOCRINOLOGY

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Assessing the potential of glucokinase activators in diabetes therapy

(2009) Franz M. Matschinsky   NATURE REVIEWS DRUG DISCOVERY

Diabetic β-Cells Can Achieve Self-Protection against Oxidative Stress through an Adaptive Up-Regulation of Their Antioxidant Defenses

(2009) Grégory Lacraz et al.   PLoS One

Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets

(2008) Séverine M. A. Pascal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorylation and regulates protein synthesis in pancreatic β-cells

(2008) Edith Gomez et al.   BIOCHEMICAL JOURNAL

Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs

(2008) Pascal Lovis et al.   BIOLOGICAL CHEMISTRY

Inhibition of Foxo1 Protects Pancreatic Islet  -Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis

(2008) S. C. Martinez et al.   DIABETES

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

miR-375 Targets 3'-Phosphoinositide-Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic  -Cells

(2008) A. El Ouaamari et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Endoplasmic Reticulum Stress-Induced Activation of Activating Transcription Factor 6 Decreases Insulin Gene Expression via Up-Regulation of Orphan Nuclear Receptor Small Heterodimer Partner

(2008) Hye-Young Seo et al.   ENDOCRINOLOGY

Reactive Oxygen Species-Mediated Pancreatic β-Cell Death Is Regulated by Interactions between Stress-Activated Protein Kinases, p38 and c-Jun N-Terminal Kinase, and Mitogen-Activated Protein Kinase Phosphatases

(2008) Ni Hou et al.   ENDOCRINOLOGY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

TRIB3 is implicated in glucotoxicity- and oestrogen receptor-stress-induced β-cell apoptosis

(2008) Bo Qian et al.   JOURNAL OF ENDOCRINOLOGY

Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)γ co-activator-1β is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells

(2008) Hannes Oberkofler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Identification of Potential Factors Associated with the Development of Type 2 Diabetes

(2008) Hongfang Lu et al.   MOLECULAR & CELLULAR PROTEOMICS

Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose

(2008) Zhi-Qiang Hou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells

(2008) Kathryn L. Lipson et al.   PLoS One

Identification of glucose-regulated miRNAs from pancreatic   cells reveals a role for miR-30d in insulin transcription

(2008) X. Tang et al.   RNA