The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells

Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell

(2013) Jiun T. Low et al.   DIABETOLOGIA

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

Ultra-structural study of insulin granules in pancreatic β-cells of db/db mouse by scanning transmission electron microscopy tomography

(2012) Yanhong Xue et al.   Protein & Cell

Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (SolubleN-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion

(2011) Natasha Behrendorff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

(2010) Kazuma Kaneko et al.   Cell Metabolism

Protons Released During Pancreatic Acinar Cell Secretion Acidify the Lumen and Contribute to Pancreatitis in Mice

(2010) Natasha Behrendorff et al.   GASTROENTEROLOGY

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules

(2009) Michael B. Hoppa et al.   Cell Metabolism

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Novel aspects of the molecular mechanisms controlling insulin secretion

(2008) Lena Eliasson et al.   JOURNAL OF PHYSIOLOGY-LONDON