The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis

(2015) Jaeseok Han et al.   DIABETES

Cleavage ofBLOC1S1mRNA by IRE1 Is Sequence Specific, Temporally Separate fromXBP1Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

(2015) Michael D. Bright et al.   MOLECULAR AND CELLULAR BIOLOGY

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells

(2014) Tongfu Xu et al.   CELL RESEARCH

Novel Bioinformatics Method for Identification of Genome-Wide Non-Canonical Spliced Regions Using RNA-Seq Data

(2014) Yongsheng Bai et al.   PLoS One

Pancreas-Specific Cre Driver Lines and Considerations for Their Prudent Use

(2013) Mark A. Magnuson et al.   Cell Metabolism

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

(2013) Quan Qiu et al.   EMBO JOURNAL

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

(2012) Justin Hassler et al.   DEVELOPMENTAL CELL

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet β-Cells

(2012) Yurika Nishiki et al.   MOLECULAR ENDOCRINOLOGY

Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion

(2012) Sonya G. Fonseca et al.   NATURE CELL BIOLOGY

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Mitochondria-targeted Antioxidants Protect Pancreatic β-cells against Oxidative Stress and Improve Insulin Secretion in Glucotoxicity and Glucolipotoxicity

(2011) Sangbin Lim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway

(2010) Sounak Gupta et al.   DIABETES

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

ER Stress in Pancreatic   Cells: The Thin Red Line Between Adaptation and Failure

(2010) D. L. Eizirik et al.   Science Signaling

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells

(2008) Kathryn L. Lipson et al.   PLoS One

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA