The role of FOXO1 in β-cell failure and type 2 diabetes mellitus

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice

(2012) Masaki Kobayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

(2012) Hongxia Ren et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Nutrition-/diet-induced changes in gene expression in pancreatic β-cells

(2012) A. Chadt et al.   DIABETES OBESITY & METABOLISM

FOXO1 in the ventromedial hypothalamus regulates energy balance

(2012) Ki Woo Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-1 Receptor Antagonist: A New Therapy for Type 2 Diabetes Mellitus

(2012) Muhammad Sajid Hamid Akash et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

(2012) Chutima Talchai et al.   NATURE GENETICS

FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization

(2012) Osamu Kikuchi et al.   PLoS One

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

(2012) Mohammed Bensellam et al.   PLoS One

Regulation of FoxO transcription factors by acetylation and protein–protein interactions

(2011) Hiroaki Daitoku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

In vivo conversion of adult α-cells into β-like cells: a new research avenue in the context of type 1 diabetes

(2011) M. Courtney et al.   DIABETES OBESITY & METABOLISM

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

(2011) Utpal B Pajvani et al.   NATURE MEDICINE

Insulin-Producing Cells Generated from Dedifferentiated Human Pancreatic Beta Cells Expanded In Vitro

(2011) Holger A. Russ et al.   PLoS One

Autophagy in health and disease. 4. The role of pancreatic β-cell autophagy in health and diabetes

(2010) Yoshio Fujitani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of autophagy in β-cell function and mass

(2010) K. Y. Hur et al.   DIABETES OBESITY & METABOLISM

What ails the β-cell?

(2010) D. Accili et al.   DIABETES OBESITY & METABOLISM

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Promotion of direct reprogramming by transformation-deficient Myc

(2010) M. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice

(2009) Tomokazu Matsuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1

(2009) T. Kitamura et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Inhibition of Foxo1 Protects Pancreatic Islet  -Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis

(2008) S. C. Martinez et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic   cells

(2008) J. Zehetner et al.   GENES & DEVELOPMENT

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

(2008) Kazuki Yasuda et al.   NATURE GENETICS